Establishing and Implementing Pneumonia Diagnosis in ED Older Adults: A Mixed Methods Approach

在急诊科老年人中建立和实施肺炎诊断：混合方法

• 批准号: 10513959
• 负责人: Katherine Hunold Buck
• 金额: $ 23.92万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10513959
• 关键词: Accident and Emergency department; Address; Adoption; Adult; Adverse effects; Antibiotics; Bacteria; Bacterial Infections; Bacterial Pneumonia; Biological Markers; COVID-19 impact; Caring; Cessation of life; Clinical; Communities; Defensins; Development; Diagnosis; Diagnostic; Diagnostic tests; Early Diagnosis; Elderly; Emergency Department Physician; Emergency Department patient; Emergency Medicine; Emergency department visit; Ensure; Event; Face; Female; Future; Genes; Geriatrics; Goals; Guidelines; Health; Human; Image; Infection; Innate Immune System; Investigation; Lead; Length of Stay; Leukocytes; Life; Maps; Measures; Methods; Mission; Modeling; Morbidity - disease rate; Natural Immunity; Outcome; Participant; Pathway interactions; Patient Care; Patients; Physicians; Pneumonia; Proteins; Recording of previous events; Research Priority; Respiratory Failure; Rural; Savings; Sepsis; Serum; Source; Subgroup; Symptoms; Testing; Theoretical Domains framework; Thinking; Thoracic Radiography; Time; United States; Validation; Viral; Viral Pneumonia; Virus; Virus Diseases; Width; Work; accurate diagnosis; adverse outcome; alpha-Defensins; antimicrobial peptide; care outcomes; clinical care; clinical diagnostics; co-infection; comorbidity; concept mapping; diagnostic accuracy; diagnostic criteria; diagnostic strategy; experience; future implementation; human old age (65+); implementation barriers; implementation science; implementation study; implementation trial; improved; male; monocyte; mortality; novel; novel diagnostics; novel marker; pathogen; pathogenic bacteria; pathogenic virus; predictive modeling; prevent; prospective; tool; usability; validation studies; young adult

PROJECT SUMMARY/ABSTRACT In the time it takes to read this application, 20 older adults (age≥65 years) will die of pneumonia in the United States. Annually over 500,000 older adults received treatment in emergency departments (ED) for pneumonia. Unfortunately, ED physicians cannot accurately diagnose pneumonia in older adults because of atypical symptoms, chest x-ray inaccuracy, comorbidities, failure of pulmonary clinical prediction rules established with younger adults, and poor accuracy of available biomarkers. Emergency physician’s inability to diagnose pneumonia in older adults leads to delayed diagnosis, inadequate treatment, worsening infection, longer lengths of stay (6.6 days vs. 5.4), and mortality. Pneumonia can be caused by bacterial and viral pathogens alone or in combination. Bacterial pneumonia alone causes the adverse outcomes and faces the diagnostic challenges just described. The presence of viral pneumonia further complicates diagnosis. Bacterial and viral co-infection in all adults increase odds of death by 2.1 with expected greater deleterious effects on older adults. Unfortunately, when viral sources are detected our current diagnostic approach fails to reliably identify bacterial sources in the event of co-infections. This can lead to inappropriate care and highlights the importance of ensuring fast, accurate diagnosis of both bacterial and viral pneumonia. Unfortunately, available tests (serum, imaging) and patient presentation (symptoms, exam, and history) are unreliable for diagnosing pneumonia in older adult ED patients. Our previous results reveal that novel tests may improve diagnostic accuracy of pneumonia (antimicrobial peptides [AMPs] and monocyte distribution width [MDW]). AMPs are a part of the innate immune system and respond in minutes to bacteria and viruses. Monocyte distribution width measures the distribution of size of leukocytes and increases in ED sepsis. This project seeks to build on previous investigations to improve the diagnostic accuracy of pneumonia in older adult ED patients with the long-term goal of improving clinical care and decreasing the morbidity and mortality associated with pneumonia. Aim #1 examines the potential for novel tests (AMPs and MDW) to diagnose pneumonia alone and in combination with patient presentation/symptoms and existing diagnostic studies. This aim will consider pneumonia caused by bacterial pathogens, viral pathogens and the combination separately to create and determine the accuracy of a diagnostic pathway. Aim #2 will employ group concept mapping guided by the Theoretical Domains Framework to engage emergency physicians to identify facilitators and barriers to implementation of a diagnostic pathway in emergency medicine to inform future studies. Aim #3 pilots the Aim #1 diagnostic pathway. If successful, this proposal will produce a diagnostic pathway for pneumonia in older adult ED patients and provide the groundwork for a successful validation and implementation study of this diagnostic pathway.

项目总结/文摘