Intra-tick and intra-host infection dynamics of a tick-borne bunyavirus
蜱传布尼亚病毒的蜱内和宿主内感染动态
基本信息
- 批准号:10513838
- 负责人:
- 金额:$ 51.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-01 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:ArbovirusesAsiaBasic ScienceBehavioralBiologyBunyaviralesBunyavirus InfectionsCase Fatality RatesCellsCharacteristicsClimateCommunicable DiseasesCutaneousDataDevelopmentDigestionDiseaseDistalEcosystemEnvironmentEpidemicEventFar EastFeedsFeverFoundationsFutureGeographyGerm CellsHaemaphysalis longicornisHemocytesHemorrhageHourImmune responseImmunologicsIncidenceInfectionInfectious Skin DiseasesInflammatoryInterventionKineticsKnowledgeLifeLife Cycle StagesMidgutModelingMoltingNatural regenerationNatureOrganOrthobunyavirusPhysiologicalPopulationProcessPublic HealthPublicationsPublishingReproductionRequest for ApplicationsResearchResearch ProposalsRoleSalivary GlandsSevere Fever with Thrombocytopenia Syndrome VirusSiteSkinSyndromeTestingThrombocytopeniaTick-Borne DiseasesTicksTimeTimeLineTissuesTropismUnited StatesVertebrate VirusesViral Load resultVirusVirus DiseasesWorkWorld Health Organizationbasefeedingin vivoinvertebrate hostnovelnovel strategiespreventresponsetick feedingtick transmissiontick-bornetick-borne flavivirustick-borne virustransmission processtreatment strategyvector tickviral transmissionvirus host interaction
项目摘要
PROJECT SUMMARY & ABSTRACT
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by the
bunyavirus, SFTS virus (SFTSV). SFTSV is transmitted by the Haemaphysalis longicornis tick, which is native
to East Asia but recently established invasive populations in the United States and continues to expand in
geographic range. The rising incidence of SFTS cases in Asia, lack of specific treatment strategies, high case
fatality rates, and global range expansion of the tick vector make SFTS a public health concern. As a tick-borne
virus, SFTSV is unique from single-host viruses because it must replicate and survive in both vertebrate and
invertebrate hosts. Currently, there is a critical need to elucidate the intra-tick and intra-host infection dynamics
that enable bunyaviruses to infect, disseminate, and persist within the distinct environments of the tick and
vertebrate host. Acquiring this fundamental knowledge is paramount to developing novel strategies that prevent
SFTSV transmission. This research proposal is in direct response to NIH RFA-AI-21-046, “Promoting
Bunyavirales Basic Science Research.” The overall objective is to define the dynamics of SFTSV infection,
dissemination, and cell tropism within the tick vector, as well as the tick-to-host transmission timeline and initial
SFTSV–host interactions in the skin. The central hypothesis is that biotic factors associated with H. longicornis’
life cycle facilitate intra-tick SFTSV dissemination to the salivary glands after molting, which in turn enables the
tick to rapidly transmit SFTSV to the next vertebrate host on which it feeds while creating an immunologically
privileged microenvironment at the skin site of tick feeding. The central hypothesis will be tested by pursuing two
specific aims: 1) Characterize the dynamics of SFTSV infection, dissemination, and transstadial survival within
H. longicornis ticks; and, 2) Define the minimum tick-to-host transmission time of SFTSV and the early host
cutaneous immune response to SFTSV-infected tick feeding. Completion of these aims will define the infection
kinetics and cell tropism of SFTSV within the tick vector across multiple life stages and within the skin of the
vertebrate host. The proposed studies will be the first to collectively examine the intra-tick and intra-host infection
dynamics of a tick-borne bunyavirus. Elucidating the fundamental H. longicornis–SFTSV–vertebrate host
interactions will enable future work towards the development of rational interventions that disrupt virus survival
within, and transmission between, the tick and vertebrate host.
项目总结及摘要
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Meghan Elizabeth Hermance其他文献
Meghan Elizabeth Hermance的其他文献
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{{ truncateString('Meghan Elizabeth Hermance', 18)}}的其他基金
Intra-tick and intra-host infection dynamics of a tick-borne bunyavirus
蜱传布尼亚病毒的蜱内和宿主内感染动态
- 批准号:
10655657 - 财政年份:2022
- 资助金额:
$ 51.82万 - 项目类别:
Evaluating the Ability of the Invasive Asian Longhorned Tick, Haemaphysalis longicornis, to Maintain and Transmit North American Tick-borne Viruses
评估入侵性亚洲长角蜱(长角血蜱)维持和传播北美蜱传病毒的能力
- 批准号:
10461932 - 财政年份:2021
- 资助金额:
$ 51.82万 - 项目类别:
Evaluating the Ability of the Invasive Asian Longhorned Tick, Haemaphysalis longicornis, to Maintain and Transmit North American Tick-borne Viruses
评估入侵性亚洲长角蜱(长角血蜱)维持和传播北美蜱传病毒的能力
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10287181 - 财政年份:2021
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