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Family Centered Approaches to Promoting Cascade Screening for Hereditary Cancer Syndromes among African Americans

以家庭为中心的方法促进非裔美国人遗传性癌症综合征的级联筛查

基本信息

批准号：
10523546
负责人：
Katrina Renee Ellis
金额：
$ 17.28万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-21 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10523546
关键词：
Active Learning Adult African American African American population Anxiety Area Attitude Award Behavior Behavioral Behavioral trial Belief Breast Cancer Burden Clinic Colorectal Communication DNA Sequence Alteration Data Death Rate Development Diet Economically Deprived Population Educational Status Educational workshop Ethnic group Evaluation Extended Family Face Family Family Caregiver Family health status Focus Groups Future Generations Genetic Genetic Counseling Germ-Line Mutation Goals Grant Health Health behavior Health education Hereditary Breast and Ovarian Cancer Syndrome Hereditary Malignant Neoplasm Hereditary Neoplastic Syndromes Individual Inherited Intervention Intervention Studies K-Series Research Career Programs Knowledge Life Longitudinal Studies Malignant Neoplasms Manuscripts Medical Genetics Mental Health Mentored Research Scientist Development Award Mentors Modification Outcome Outcome Study Persons Physical activity Politics Population Positioning Attribute Process Public Health Race Randomized Clinical Trials Reading Recording of previous events Reporting Research Research Personnel Resources Risk Self Determination Smoking Social Work Spirituality Test Result Testing United States Writing acceptability and feasibility base behavior change cancer genetics cancer health disparity cancer risk cancer type career career development commune communication behavior communication theory contextual factors coping eHealth experience genetic information genetic testing health disparity hereditary risk high risk improved improved outcome lifestyle intervention motivational enhancement therapy pilot test post-doctoral training psychosocial racial and ethnic response screening skills social symposium tailored messaging testing uptake theories therapy design therapy development uptake

项目摘要

Research has shown that African Americans are less likely than other racial groups to engage in genetic testing for hereditary cancer syndromes, which can uncover genetic mutations that increase cancer risk. African Americans also have lower rates of cancer cascade testing, a process for providing genetic counseling and testing for relatives of African Americans who are known carriers of specific cancer-related genetic mutations. As clinical genetic testing becoming increasingly available, it is critically important to design interventions to reach all populations, especially those that have been traditionally underserved. Tailored strategies are particularly useful for increasing intervention access and uptake where health disparities exist. This career development award provides Dr. Ellis the opportunity to develop and test a family-tailored intervention to increase cancer cascade testing among African Americans. This award focuses on strengthening the investigator’s skills in intervention research and cancer genetics. Her long-term career goal is to become an independent investigator with expertise in conducting family-based intervention research to improve cancer outcomes among African Americans. Dr. Ellis’ graduate-level training in public health (health behavior and education) and social work (interpersonal practice with individuals and families), and postdoctoral training in cancer health disparities, puts her in a unique position to develop interventions that attend to both the psychosocial and behavioral aspects of cancer genetic testing for African American families. The career development goals and mentoring plan include courses and workshops; guided mentoring, including directed readings with mentors; experiential learning, including shadowing in a cancer genetics clinic and intervention development, testing, and evaluation; tailored health messaging development; attendance and participation at professional conferences; and, manuscript and grant writing and submissions. These activities support the execution of the specific aims, which are to: (1) Identify intrapersonal and interpersonal facilitators and barriers to African American family communication about genetic testing and cascade testing through eight focus groups; (2) Develop a tailored, eHealth intervention for African American families that encourages uptake of recommended cascade genetic testing by improving communication about genetic testing results and targeting drivers of and barriers to behavior change (e.g., knowledge, attitudes, skills for communication and testing); (3) Conduct a pilot test of the intervention with 30 families to evaluate intervention feasibility, acceptability and engagement and explore its potential impact on cascade testing. Dr. Ellis’ mentoring team has expertise in each of her key developmental areas. At the completion of this K01 award, Dr. Ellis will have the expertise to become an independent investigator who conducts family-based intervention research to improve cancer outcomes with African American families with increased cancer risk.

研究表明，非裔美国人比其他种族群体更不可能参与基因遗传性癌症综合征检测，可以发现增加癌症风险的基因突变。非裔美国人的癌症级联测试的比率也较低，这是一种提供遗传咨询的过程以及对已知携带特定癌症相关基因的非裔美国人的亲属进行检测突变。随着临床基因检测的日益普及，设计干预措施覆盖所有人口，特别是那些传统上服务不足的人。量身定做在存在健康差距的地方，战略对于增加干预、获取和利用特别有用。这一职业发展奖为埃利斯博士提供了开发和测试量身定做的家庭的机会在非裔美国人中增加癌症级联检测的干预措施。该奖项的重点是加强研究人员在干预研究和癌症遗传学方面的技能。她的长期职业目标是成为一名独立的调查员，在进行基于家庭的干预研究方面具有专业知识改善非裔美国人的癌症预后。埃利斯博士在公共卫生(卫生)方面的研究生培训行为和教育)和社会工作(与个人和家庭的人际关系实践)和博士后在癌症健康差异方面的培训，使她处于一个独特的位置，可以开发既能照顾到癌症健康差异，又能照顾到两者的干预措施非裔美国家庭癌症基因检测的心理社会和行为方面。职业生涯发展目标和指导计划包括课程和讲习班；指导指导，包括指导与导师一起阅读；体验式学习，包括在癌症遗传学诊所的跟踪和干预开发、测试和评估；量身定制的健康信息开发；出席和参与专业会议；以及手稿和赠款的撰写和提交。这些活动支持执行具体目标，即：(1)确定个人内部和人际间的促进者和障碍通过八个焦点向非裔美国人家庭传播基因检测和级联检测 (2)为非裔美国家庭制定量身定做的电子健康干预措施，鼓励他们接受通过改善对基因检测结果和目标的沟通，推荐级联基因检测行为改变的驱动力和障碍(例如，沟通和测试的知识、态度、技能)；对30个家庭进行干预的试点测试，以评估干预的可行性、可接受性和参与并探索其对级联测试的潜在影响。埃利斯博士的指导团队在她的每一个关键发展领域。在K01奖项完成后，埃利斯博士将拥有以下专业知识成为一名独立的调查者，进行基于家庭的干预研究以改善癌症癌症风险增加的非裔美国家庭的结果。