Lifecourse food insecurity and dementia risk

生命全程粮食不安全和痴呆风险

• 批准号: 10525485
• 负责人: SUZANNA M MARTINEZ
• 金额: $ 241.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10525485
• 关键词: Acute; Adult; Age; Algorithms; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Attention; Cause of Death; Child; Chronic; Cognition; Complement; Cross-Sectional Studies; Data; Data Security; Data Set; Data Sources; Dementia; Elderly; Eligibility Determination; Ethnic Origin; Food; Food Assistance Programs; Future; Gender; Generations; Geography; Goals; Health and Retirement Study; Heterogeneity; Impaired cognition; Individual; Interdisciplinary Study; Intervention; Longitudinal Studies; Longterm Follow-up; Measures; Memory Loss; National Longitudinal Survey of Youth; Outcome; Participant; Pattern; Persons; Policies; Population; Prevention; Race; Research; Research Personnel; Sequence Analysis; Socioeconomic Status; Time; United States; Work; cognitive change; cognitive function; cognitive performance; cognitive testing; cohort; college; cost; dementia risk; dietary supplements; experience; follow-up; food insecurity; food security; innovation; middle age; novel; nutrition; programs; prospective; social; socioeconomic disparity; systematic review

PROJECT ABSTRACT Dementia is the 6th leading cause of death in the U.S. with marked disparities by socioeconomic status, gender, and race/ethnicity. Food insecurity is a common experience in U.S. children and adults, and it likely influences Alzheimer's Disease and Alzheimer's Related Dementias (AD/ADRD) via multiple mechanisms. Yet, there is almost no quantitative research evaluating food insecurity and AD/ADRD. The very limited prior work in this area is cross-sectional which introduces challenges: 1) the temporal ordering of food insecurity and cognitive performance is ambiguous; 2) researchers are unable to disentangle if acute vs. chronic food insecurity differentially impacts dementia risk; and 3) measuring cognitive assessments at a single time point precludes the possibility of evaluating cognitive decline. Through innovative uses of the U.S. Health and Retirement Study (HRS), and the National Longitudinal Survey of Youth, 1979 cohort (NLSY79), the proposed research fills this critical gap. Both data sources collect prospective information on food insecurity and dementia risk among older adults (HRS), and across the lifecourse (NLSY79). We will leverage the complementary strengths of these datasets to evaluate: [1] if food insecurity among older adults predicts dementia risk (Aim 1; HRS); [2] if lifecourse food insecurity (from ages 18 – 48) predicts dementia risk (Aim 2; NLY79); and [3] if Supplemental Nutritional Assistant Program (SNAP) benefit amount patterns (ages 18 – 48) predict dementia risk (Aim 3; NLY79; SNAP is a federal food insecurity alleviation program). This innovative work on lifecourse food insecurity is possible through our novel application of sequence analysis, which will be applied to markers of food insecurity collected over time in both nationally representative data sources. Our research questions focus on food insecurity, which is a modifiable target for AD/ADRD prevention that is biologically plausible, common, and potentially high impact through existing policy interventions, such as SNAP.

项目摘要 痴呆症是美国的第六大死亡原因，其社会经济地位明显差异， 性别和种族/种族。粮食不安全是美国儿童和成人的普遍经历，很可能 通过多种机制影响阿尔茨海默氏病和阿尔茨海默氏症相关的痴呆症（AD/ADRD）。然而， 几乎没有评估粮食不安全和AD/ADRD的定量研究。先前的工作非常有限 该区域是横截面，引入了挑战：1）粮食不安全感的临时订购和 认知表现模棱两可； 2）如果急性与慢性食物，研究人员将无法解散 不安全感会对痴呆症风险产生不同的影响； 3）在一个时间点测量认知评估 排除评估认知能力下降的可能性。通过对美国卫生的创新用途和 退休研究（HRS）和《青年纵向调查》，1979年同类（NLSY79），拟议的 研究填补了这个关键的空白。两个数据源都会收集有关粮食不安全和的前瞻性信息 老年人（HRS）以及整个生命阶段（NLSY79）的痴呆症风险。我们将利用 这些数据集的互补优势要评估：[1]如果老年人的粮食不安全性预测 痴呆症风险（AIM 1; HRS）； [2]如果生命力粮食不安全（18-48岁）预测痴呆症风险（AIM 2； nly79）; [3]如果补充营养助理计划（SNAP）福利金额模式（18-48岁） 预测痴呆症风险（AIM 3； NLY79； SNAP是联邦粮食不安全的减轻计划）。这种创新 通过我们的新型序列分析应用，生命性粮食不安全的工作可能是可能的，这将是 应用于在两个国家代表性数据源中随着时间收集的粮食不安全标记。我们的 研究问题的重点是粮食不安全，这是预防AD/ADRD的可修改目标 通过现有的政策干预措施（例如 折断。

项目成果

Food Insecurity, Memory, and Dementia Among US Adults Aged 50 Years and Older.

• DOI: 10.1001/jamanetworkopen.2023.44186
• 发表时间: 2023-11-01
• 期刊: JAMA NETWORK OPEN
• 影响因子: 13.8
• 作者: Qian, Haobing;Khadka, Aayush;Martinez, Suzanna M.;Singh, Sonali;Brenowitz, Willa D.;Zeki Al Hazzouri, Adina;Hill-Jarrett, Tanisha G.;Glymour, M. Maria;Vable, Anusha M.
• 通讯作者: Vable, Anusha M.