The Role of Osteopontin-OGDHL Axis in HFpEF

摘要 这一少数民族补充计划的目标是培训和指导一名代表不足的牙买加年轻人。 从一名受过医学训练的医生过渡到内科科学家的女士。威廉姆斯博士是 一位雄心勃勃的博士后候选人，通过健康差距和 佛罗里达国际大学(FIU)的文化认同研究实验室评估HPV风险。她 也是东南研究生教育联盟和教授的获奖者 (SEAGEP)2010年度本科生研究奖。在此期间，她协助 为FIU生物材料实验室制定实验室规程。威廉姆斯博士是 由另一位当前的多样性补充奖获得者(Julian Dunkley博士)介绍给我们的团队。 威廉姆斯了解到了我们由NIH资助的HFpEF项目，并对培训产生了极大的兴趣 基础研究和翻译研究。如果获得批准，这份博士后补充资料将与 跨学科干细胞的优良环境、支持和非凡资源 研究所和迈阿密大学米勒医学院将为威廉姆斯博士提供 成为一名独立的内科科学家所需的工具和方法 牙买加女科学家很少的心血管研究。这个建议是合乎逻辑的 延长题为“OPN-OGDHL轴在HFpEF中的作用”的父母赠款(1R01HL140468) 并在原始项目的范围内执行。因此，我们将描述血液的特征 我们最近建立的新的HFpEF心肾小鼠模型的血压和心率 以植入遥测设备为特征的。我们将评估Alport小鼠的心律失常 ±β受体激动剂/拮抗剂。所使用的小鼠将来自我们所使用的三种不同的基因菌株 发展起来的。这一新方法几乎没有修改所提出的战略和模型，这保持了 这些额外的实验在父母资助的范围内。建议的实验是 预计在未来14个月内完工。

ABSTRACT The goal of this minority supplement is to train and mentor an underrepresented Jamaican young lady during her transition from a medically-trained doctor to a physician scientist. Dr. Williams is an ambitious post-doctoral candidate who performed research via the Health Disparities & Cultural Identities research lab at Florida International University (FIU) assessing HPV risk. She was also a recipient of the South East Alliance for Graduate Education and the Professoriate (SEAGEP) award for undergraduate research in 2010. During this period, she assisted with the development of laboratory protocols for the Biomaterials laboratory at FIU. Dr. Williams was introduced to our team by another current Diversity Supplement awardee (Dr Julian Dunkley). Williams learnt about our NIH-funded HFpEF project and became very interested in training in basic and translation research. If granted, this postdoctoral supplement combined with the excellent environment, support, and extraordinary resources at the Interdisciplinary Stem Cell Institute and the University of Miami Miller School of Medicine will provide Dr. Williams with the tools and methodology necessary to become an independent physician scientist in the field of cardiovascular research where female Jamaican scientists are rare. This proposal is the logical extension of the parent grant entitled “Role of OPN-OGDHL Axis in HFpEF” (1R01HL140468) and is performed within the scope of the original project. As such, we will characterize the blood pressure and heart rhythm in the new HFpEF cardio-renal mouse model we recently characterized by implanting a telemetry device. We will assess the arrhythmia in the Alport mouse ± beta agonist/antagonists. The mice used will be from the three different genetic strains that we developed. This new approach barely modifies the proposed strategy and models, which keeps these additional experiments within the scope of the parent grant. The proposed experiments are anticipated to finish within the next 14 months.