The Role of Osteopontin-OGDHL Axis in HFpEF

骨桥蛋白-OGDHL 轴在 HFpEF 中的作用

• 批准号: 10524637
• 负责人: Lina A Shehadeh
• 金额: $ 9.49万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10524637
• 关键词: Agonist; Arrhythmia; Award; Basic Science; Biocompatible Materials; Blood Pressure; Cardiovascular system; Clinical Trials; Complex; Development; Devices; Disease; EFRAC; Environment; Etiology; Failure; Female; Florida; Funding; Goals; Graduate Education; Grant; Heart failure; Human Papillomavirus; Implant; Institutes; International; Jamaican; Kidney; Laboratories; Medical; Mentors; Methodology; Minority; Modeling; Mus; Physicians; Postdoctoral Fellow; Protocols documentation; Research; Resources; Risk; Role; Scientist; Syndrome; Telemetry; Training; Translational Research; Treatment Failure; United States National Institutes of Health; Universities; antagonist; disease heterogeneity; disease phenotype; experimental study; genetic strain; health disparity; heart rhythm; insight; interest; laboratory development; medical schools; mouse model; novel strategies; osteopontin; parent grant; preservation; stem cells; tool; undergraduate research

ABSTRACT The goal of this minority supplement is to train and mentor an underrepresented Jamaican young lady during her transition from a medically-trained doctor to a physician scientist. Dr. Williams is an ambitious post-doctoral candidate who performed research via the Health Disparities & Cultural Identities research lab at Florida International University (FIU) assessing HPV risk. She was also a recipient of the South East Alliance for Graduate Education and the Professoriate (SEAGEP) award for undergraduate research in 2010. During this period, she assisted with the development of laboratory protocols for the Biomaterials laboratory at FIU. Dr. Williams was introduced to our team by another current Diversity Supplement awardee (Dr Julian Dunkley). Williams learnt about our NIH-funded HFpEF project and became very interested in training in basic and translation research. If granted, this postdoctoral supplement combined with the excellent environment, support, and extraordinary resources at the Interdisciplinary Stem Cell Institute and the University of Miami Miller School of Medicine will provide Dr. Williams with the tools and methodology necessary to become an independent physician scientist in the field of cardiovascular research where female Jamaican scientists are rare. This proposal is the logical extension of the parent grant entitled “Role of OPN-OGDHL Axis in HFpEF” (1R01HL140468) and is performed within the scope of the original project. As such, we will characterize the blood pressure and heart rhythm in the new HFpEF cardio-renal mouse model we recently characterized by implanting a telemetry device. We will assess the arrhythmia in the Alport mouse ± beta agonist/antagonists. The mice used will be from the three different genetic strains that we developed. This new approach barely modifies the proposed strategy and models, which keeps these additional experiments within the scope of the parent grant. The proposed experiments are anticipated to finish within the next 14 months.

抽象的 这项少数族裔补充计划的目标是培训和指导代表性不足的牙买加年轻人 女士从一名受过医学训练的医生转变为一名医学科学家。威廉姆斯博士是 一位雄心勃勃的博士后候选人，通过健康差异和 佛罗里达国际大学 (FIU) 文化身份研究实验室评估 HPV 风险。她 也是东南研究生教育联盟和教授的获得者 (SEAGEP) award for undergraduate research in 2010. During this period, she assisted with the 为佛罗里达国际大学生物材料实验室制定实验室协议。威廉姆斯博士是 由另一位现任多样性补充奖获得者（朱利安·邓克利博士）介绍给我们的团队。 Williams 了解了我们 NIH 资助的 HFpEF 项目，并对以下方面的培训非常感兴趣 基础研究和翻译研究。如果获得批准，该博士后补充品将与 跨学科干细胞的优良环境、支持和非凡资源 研究所和迈阿密大学米勒医学院将为威廉姆斯博士提供 成为该领域的独立医师科学家所需的工具和方法 牙买加女性科学家很少见的心血管研究领域。这个提议是合乎逻辑的 延长题为“OPN-OGDHL 轴在 HFpEF 中的作用”的母基金 (1R01HL140468) 并在原项目范围内进行。因此，我们将表征血液 我们最近在新的 HFpEF 心肾小鼠模型中测量了压力和心律 其特点是植入遥测装置。我们将评估 Alport 小鼠的心律失常 ± β 激动剂/拮抗剂。使用的小鼠将来自我们研究的三种不同的遗传品系 发达。这种新方法几乎没有修改所提出的策略和模型，这使得 这些额外的实验在父资助的范围内。提议的实验是 anticipated to finish within the next 14 months.

项目成果

Peptide-Functionalized Dendrimer Nanocarriers for Targeted Microdystrophin Gene Delivery.

• DOI: 10.3390/pharmaceutics13122159
• 发表时间: 2021-12-15
• 期刊: Pharmaceutics
• 影响因子: 5.4
• 作者: Hersh J;Condor Capcha JM;Iansen Irion C;Lambert G;Noguera M;Singh M;Kaur A;Dikici E;Jiménez JJ;Shehadeh LA;Daunert S;Deo SK
• 通讯作者: Deo SK

Methylene Blue Is a Nonspecific Protein-Protein Interaction Inhibitor with Potential for Repurposing as an Antiviral for COVID-19.

• DOI: 10.3390/ph15050621
• 发表时间: 2022-05-18
• 期刊: PHARMACEUTICALS
• 影响因子: 4.6
• 作者: Chuang, Sung-Ting;Papp, Henrietta;Kuczmog, Anett;Eells, Rebecca;Capcha, Jose M. Condor;Shehadeh, Lina A.;Jakab, Ferenc;Buchwald, Peter
• 通讯作者: Buchwald, Peter

Ascending aortic aneurysm and histopathology in Alport syndrome: a case report.

• DOI: 10.1186/s12882-023-03345-5
• 发表时间: 2023-10-12
• 期刊: BMC NEPHROLOGY
• 影响因子: 2.3
• 作者: Kamiar, Ali;Alitter, Qusai;Capcha, Jose M. C.;Saad, Ali;Webster, Keith A.;Shehadeh, Lina A.
• 通讯作者: Shehadeh, Lina A.

Autoimmune Reaction Associated With Long COVID Syndrome and Cardiovascular Disease: A Genetic Case Report.

• DOI: 10.1016/j.jaccas.2022.09.014
• 发表时间: 2023-01-18
• 期刊: JACC. Case reports
• 作者: Safronenka, Anita;Capcha, Jose M C;Webster, Keith A;Buglo, Elena;Tamariz, Leonardo;Goldberger, Jeffrey J;Shehadeh, Lina A
• 通讯作者: Shehadeh, Lina A

Mouse Model of Heart Failure With Preserved Ejection Fraction Driven by Hyperlipidemia and Enhanced Cardiac Low-Density Lipoprotein Receptor Expression.

• DOI: 10.1161/jaha.122.027216
• 发表时间: 2022-09-06
• 期刊: JOURNAL OF THE AMERICAN HEART ASSOCIATION
• 影响因子: 5.4
• 作者: Williams, Monique;Capcha, Jose Manuel Condor;Irion, Camila Iansen;Seo, Grace;Lambert, Guerline;Kamiar, Ali;Yousefi, Keyan;Kanashiro-Takeuchi, Rosemeire;Takeuchi, Lauro;Saad, Ali G.;Mendez, Armando;Webster, Keith A.;Goldberger, Jeffrey J.;Hare, Joshua M.;Shehadeh, Lina A.
• 通讯作者: Shehadeh, Lina A.