Transcription Factor Networks in Cardiac Hypertrophy
心脏肥大中的转录因子网络
基本信息
- 批准号:7394365
- 负责人:
- 金额:$ 4.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-04-08 至 2008-12-31
- 项目状态:已结题
- 来源:
- 关键词:AlgorithmsBinding SitesBiologicalBiological AssayBiological ProcessBlast CellCandidate Disease GeneCardiacComplexComputer SimulationComputer softwareDataData SetDatabasesDeoxyribonuclease IDiseaseEP300 geneElementsExperimental DesignsFellowshipFlaxGene ExpressionGenerationsGenesHealthHeartHeart DiseasesHeart HypertrophyHumanHypersensitivityHypertrophyIndividualKnowledgeLinkLiteratureMalignant NeoplasmsModelingMolecular ProfilingMusMutateNamesOnline SystemsPhylogenetic AnalysisRNARattusRecoveryRegulatory ElementRegulatory PathwayRunningSamplingSystemTransfectionTreesValidationdrug developmentin vivointerestmouse modelnovelpressurepromoterresearch studyresponsetooltranscription factor
项目摘要
DESCRIPTION (provided by applicant): The broad objective is to develop an analysis strategy for heart expression data and use it to identify without any preconceived knowledge of disease-associated genes the key genes, their targets, and their regulatory pathway, and to validate these results in biological systems. Specific Aims are: I: Link hypertrophy associated genes to transcriptional regulatory networks. II: Optimize the strategy for application to other cardiac gene expression data sets. Health Relatedness: A better understanding of the function of a p300- driven network in vivo is essential to guiding drug development both in cancer and heart disease. The experimental design includes running microarrays on murine models of hypertrophy, generating and applying novel statistical approaches to microarray data to extract genes related to hypertrophy, generating mathematical representations to visualize global expression profiles in 3D, studying promoter organization in silico to identify complex regulatory elements, searching the eukaryotic promoter database for these complex elements to find co-regulated genes, validating the complex elements in vivo using ChIP assay, overlapping the network from microarrays and literature to promoter driven network to find unknown candidate genes.
描述(由申请人提供):广泛的目标是开发心脏表达数据的分析策略,并在没有任何疾病相关基因的先入为主的知识的情况下使用它来识别关键基因、其靶标及其调控途径,并在生物系统中验证这些结果。具体目的是:I:连接肥大相关基因的转录调控网络。II:优化应用于其他心脏基因表达数据集的策略。健康相关性:更好地了解体内p300驱动网络的功能对于指导癌症和心脏病药物开发至关重要。实验设计包括在肥大的小鼠模型上运行微阵列,产生并将新的统计方法应用于微阵列数据以提取与肥大相关的基因,产生数学表示以在3D中可视化全局表达谱,通过计算机研究启动子组织以鉴定复杂的调控元件,在真核启动子数据库中搜索这些复杂元件以找到共调控基因,利用ChIP技术在体内验证复杂元件,将基因芯片和文献中的网络重叠到启动子驱动的网络中,寻找未知的候选基因。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
SRRM2, a potential blood biomarker revealing high alternative splicing in Parkinson's disease.
- DOI:10.1371/journal.pone.0009104
- 发表时间:2010-02-08
- 期刊:
- 影响因子:3.7
- 作者:Shehadeh LA;Yu K;Wang L;Guevara A;Singer C;Vance J;Papapetropoulos S
- 通讯作者:Papapetropoulos S
Expression of alpha-synuclein mRNA in Parkinson's disease.
帕金森病中 α-突触核蛋白 mRNA 的表达。
- DOI:10.1002/mds.21466
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Papapetropoulos,Spiridon;Adi,Nikhil;Mash,DeborahC;Shehadeh,Lina;Bishopric,Nanette;Shehadeh,Lina
- 通讯作者:Shehadeh,Lina
Is the G2019S LRRK2 mutation common in all southern European populations?
- DOI:10.1016/j.jocn.2007.08.013
- 发表时间:2008-09-01
- 期刊:
- 影响因子:2
- 作者:Papapetropoulos, Spiridon;Adi, Nikhil;Chroni, Elizabeth
- 通讯作者:Chroni, Elizabeth
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Lina A Shehadeh其他文献
Lina A Shehadeh的其他文献
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{{ truncateString('Lina A Shehadeh', 18)}}的其他基金
The Role of Osteopontin-OGDHL Axis in HFpEF
骨桥蛋白-OGDHL 轴在 HFpEF 中的作用
- 批准号:
10524637 - 财政年份:2018
- 资助金额:
$ 4.22万 - 项目类别:
The Role of Osteopontin-OGDHL Axis in HFpEF
骨桥蛋白-OGDHL 轴在 HFpEF 中的作用
- 批准号:
9795565 - 财政年份:2018
- 资助金额:
$ 4.22万 - 项目类别:
Osteopontin Signals between Myocytes and Fibroblasts to Regulate Cardiac Remodeling
肌细胞和成纤维细胞之间的骨桥蛋白信号调节心脏重塑
- 批准号:
9336424 - 财政年份:2016
- 资助金额:
$ 4.22万 - 项目类别:
Mechanisms for miR-30e Regulated Atherogenic Pathways with Age
miR-30e随年龄调节动脉粥样硬化通路的机制
- 批准号:
8718967 - 财政年份:2012
- 资助金额:
$ 4.22万 - 项目类别:
Mechanisms for miR-30e Regulated Atherogenic Pathways with Age
miR-30e随年龄调节动脉粥样硬化通路的机制
- 批准号:
8549049 - 财政年份:2012
- 资助金额:
$ 4.22万 - 项目类别:
Mechanisms for miR-30e Regulated Atherogenic Pathways with Age
miR-30e随年龄调节动脉粥样硬化通路的机制
- 批准号:
8300301 - 财政年份:2012
- 资助金额:
$ 4.22万 - 项目类别:
Transcription Factor Networks in Cardiac Hypertrophy
心脏肥大中的转录因子网络
- 批准号:
7056336 - 财政年份:2006
- 资助金额:
$ 4.22万 - 项目类别:
Transcription Factor Networks in Cardiac Hypertrophy
心脏肥大中的转录因子网络
- 批准号:
7233688 - 财政年份:2006
- 资助金额:
$ 4.22万 - 项目类别:
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