Mentoring in Patient-Oriented Neuroscience Research

以患者为导向的神经科学研究的指导

• 批准号: 10525537
• 负责人: MARISA M SILVERI
• 金额: $ 16.28万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-08 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10525537
• 关键词: Address; Adolescent; Adult; Alcohol abuse; Alcohol consumption; Alcohols; Ancillary Study; Anxiety; Anxiety Disorders; Applications Grants; Area; Award; Big Data; Boston; Brain; COVID-19 pandemic; Child Abuse and Neglect; Child Traumatic Stress; Clinical; Clinical Research; Collaborations; Cultural Diversity; Data; Data Analyses; Development; Development Plans; Diagnosis; Disadvantaged; Doctor of Philosophy; Education; Environment; Exposure to; Faculty; Fostering; Foundations; Funding; Future; Gender; Gender Identity; Goals; Grant; Group Therapy; Hospitals; Hour; Human; Individual; Inequality; Interdisciplinary Study; Intervention; Intervention Studies; Interview; Knowledge; Laboratories; Longevity; Mental Depression; Mental Health; Mental disorders; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Minority Groups; Monitor; Mood Disorders; NCI Scholars Program; National Institute of Drug Abuse; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Neurobiology; Neurocognitive; Neurosciences Research; Paper; Patients; Peer Review; Peer Review Grants; Peptides; Population; Population Study; Preparation; Prevention; Principal Investigator; Psychiatry; Psychopathology; Public Health; Publications; Publishing; Recovery; Regimen; Research; Research Personnel; Residencies; Resources; Risk; Role; SECTM1 gene; Sexual and Gender Minorities; Site; Stress; Time; Training; Underrepresented Minority; United States National Institutes of Health; Vulnerable Populations; Women' s Health; Work; Yoga; Youth; addiction; adolescent brain development; alcohol misuse; alcohol research; alcohol risk; alcohol use disorder; career; career development; child depression; childhood anxiety; comorbidity; depressive symptoms; effective therapy; emerging adult; ethnic disadvantage; ethnic diversity; experience; health disparity; inner city; lectures; medical schools; meetings; mid-career faculty; minority children; minority trainee; neurodevelopment; neuroimaging; next generation; outreach; patient oriented; patient oriented research; patient population; pre-clinical; programs; racial and ethnic; racial diversity; skills; stem; substance use; success; transgender; underage drinking; undergraduate student; vulnerable adolescent

PROJECT SUMMARY I am a clinical researcher and Director of the Neurodevelopmental Laboratory on Addictions and Mental Health at McLean Hospital. I also am an Associate Professor in Psychiatry at Harvard Medical School. I have been continuously funded as a principal investigator (PI) to conduct NIAAA-sponsored patient-oriented research (POR) since 2004 and have been a collaborator and consultant on multiple NIH-sponsored grants. My research focusing on understanding adolescent brain development, and risk for and underlying neurobiology of addiction and psychiatric disorders. During the first 5-year K24 period, I provided mentoring to 50 individuals ranging in rank from undergraduates through psychiatry residents and junior faculty. These mentees have made notable success, including publishing papers, submitting grant applications and being promoted. I work in a rich environment for clinical research, which is ideal for providing mentoring in POR. As I receive no institutional support for mentoring and will be required to curtail mentoring efforts to assume significant non- research responsibilities, a K24 renewal will continue to provide protected time that would allow me to maintain and increase my intensive mentorship to trainees, and attract new research mentees to POR. My immediate and long-term career objectives are to continue characterizing neurobiological markers in addiction and psychiatric disorders, which will inform the development of new and effective treatments for alcohol use disorders and for individuals with dual diagnoses, and to train the next generation of investigators to develop the skills they require to effectively conduct POR. I remain committed to disseminating research findings (through publications, scientific lectures and public outreach) and provide mentoring to trainees in public outreach, the goal of which is to provide education around alcohol research, which in turn will help prevention efforts and inform treatment interventions, to aid in the reduction of suffering due to alcohol use and abuse. The specific aims to be accomplished during the period of the award are to 1) provide substantive mentoring of junior investigators and trainees in POR (35%), with a focus on mentoring underrepresented minority trainees; 2) continue and extend involvement in my POR (10%), and 3) advance my expertise in the content areas of adolescent comorbid psychopathology, clinical approaches in adolescent treatment, and conducting research in vulnerable adolescent and adult populations, including racial/ethnically disadvantaged youth and those navigating gender identity development, both with established evidence of mental health disparities (5%). Despite the challenges imposed by the COVID19 pandemic, these mentoring relationships have continued to grow, and trainees are making significant strides in their paths toward POR. I remain deeply committed to the continued training of a remarkable group of mentees, who are the future of addiction and psychiatry POR. Through intensive mentoring I will enhance my POR by increasing my clinical perspectives, and by incorporating treatment and multicultural considerations into my POR initiatives.

项目总结 我是一名临床研究员，也是成瘾与心理健康神经发育实验室的主任 在麦克莱恩医院。我也是哈佛医学院的精神病学副教授。我一直在 作为首席研究员(PI)持续资助NIAAA赞助的以患者为中心的研究 自2004年以来，他一直是NIH赞助的多笔赠款的合作者和顾问。我的 研究重点是了解青少年的大脑发育，以及患上和潜在的神经生物学 成瘾和精神障碍。在最初的5年K24期间，我为50个人提供了指导 级别从本科生到精神病学住院医生和初级教员。这些学员拥有 取得了显著的成功，包括发表论文、提交拨款申请和获得晋升。我在工作 在丰富的临床研究环境中，这是在POR中提供指导的理想选择。因为我没有收到 对辅导的机构支持，并将需要减少辅导努力，以承担重大的非 研究责任，K24续订将继续提供保护时间，使我能够保持 并增加我对学员的密集指导，并吸引新的研究导师到POR。我的直系亲属 长期的职业目标是继续表征成瘾和上瘾的神经生物学标志 精神障碍，这将为酒精使用新的有效治疗方法的发展提供信息 对于患有双重诊断的个人，以及培训下一代研究人员以开发 他们有效开展POR所需的技能。我将继续致力于传播研究成果 (通过出版物、科学讲座和公众宣传)，并在公共场合向学员提供指导 外展，其目标是提供有关酒精研究的教育，这反过来将有助于预防 努力并告知治疗干预措施，以帮助减少因饮酒和滥用而遭受的痛苦。 在获奖期间要实现的具体目标是：1)提供实质性的指导 初级调查员和初级受训人员(35%)，重点是指导代表性不足的少数族裔受训人员； 2)继续参与我的POR(10%)，3)提升我在以下内容领域的专业知识 青春期共病精神病理学，青春期治疗的临床方法，以及进行研究 在脆弱的青少年和成人群体中，包括种族/族裔处境不利的青年和 引导性别认同的发展，两者都有心理健康差异的确凿证据(5%)。 尽管面临COVID19大流行的挑战，但这些指导关系继续 增长，学员们在通往POR的道路上取得了重大进展。我仍然深深地致力于 继续培训一批杰出的学员，他们是成瘾和精神病学POR的未来。 通过密集的指导，我将通过增加我的临床视角来提高我的POR，并通过 将待遇和跨文化考虑纳入我的POR倡议。