Intergenerational Vestiges of Childhood Maltreatment: Physiological Mediating Mechanisms of Parenting

童年虐待的代际痕迹：养育的生理中介机制

• 批准号: 10533944
• 负责人: Hannah Grace Swerbenski
• 金额: $ 4.68万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10533944
• 关键词: Achievement; Address; Adrenal Glands; Affect; Affective; Age; Area; Award; Behavior; Behavioral; Biological; Caustics; Cessation of life; Child; Child Abuse and Neglect; Child Rearing; Complement; Cues; Data; Development; Dimensions; Distress; Emotional; Exposure to; Fostering; Future Generations; Generations; Goals; Heart Diseases; Homeostasis; Human; Hypothalamic structure; Impaired cognition; Informal Social Control; Intervention; Knowledge; Life; Link; Longevity; Longitudinal Studies; Low income; Mediating; Mediator of activation protein; Mentors; Mentorship; Methods; Modeling; Mothers; Motivation; Obesity; Outcome; Parasympathetic Nervous System; Parent-Child Relations; Parents; Pathway interactions; Physiological; Physiology; Pituitary Gland; Postpartum Period; Pregnant Women; Prevention; Process; Psychopathology; Public Health; Recording of previous events; Recovery; Research; Research Personnel; Research Training; Risk; Risk Factors; Scientist; Social Environment; Specificity; System; Time; Training; Translational Research; Withdrawal; Woman; Work; biological adaptation to stress; biopsychosocial; career; caregiving; clinical practice; cognitive function; cost; early childhood; fighting; flexibility; high risk; hypothalamic-pituitary-adrenal axis; infancy; informant; intergenerational; maltreatment; maternal caregiving; next generation; novel; parental influence; perinatal period; physical conditioning; postnatal; prenatal; programs; prospective; psychological outcomes; resilience; response; skills; social engagement; stress reactivity; substance use; theories; training opportunity; transmission process

PROJECT SUMMARY/ABSTRACT Childhood maltreatment constitutes a grave public health crisis associated with devastating lifelong costs, including heightened risk for psychopathology1,2 and substance use,3 poorer socioemotional functioning,4,5 impaired cognitive functioning,6,7 lower educational attainment,8 and physical health problems9 such as heart disease,10 obesity,11 and even early death.12 Crucially, the deleterious costs of childhood maltreatment are not limited to those directly affected, but can also spillover into future generations via disrupted parenting and caregiving practices.13 Thus, identification of intervening mechanisms that may explain associations between maltreatment histories and parenting in the next generation can inform theory in this area of research and illuminate meaningful points of intervention in clinical practice. The long-term objective of the proposed project is to examine multisystem physiological stress reactivity indicators as mediators of associations between maternal maltreatment histories and parenting during the perinatal period. The novelty of this project is twofold. First, this project will examine both Hypothalamic-Pituitary-Adrenal reactivity (Aim 1) and Parasympathetic Nervous System reactivity (Aim 2) as intervening links between maltreatment and parenting during a key developmental period. This is the first study to examine more than one physiological mediator of this association concurrently, as well as the first study to examine parasympathetic reactivity specifically. Second, informed by a Domain-Specific Approach14 to parenting, this project provides much-needed specificity in differential associations between physiology and parenting outcomes across the protection and reciprocity domains. This work addresses limitations of prior research by leveraging an existing prospective, longitudinal, study (n=85) of diverse, low-income women. The applicant’s dedicated mentorship team of expert investigators will foster the applicant's development in this important research area. Finally, the award and completion of this project will substantially aid in providing strong research training to a promising young scientist in developmental psychopathology, intergenerational transmission processes, and human physiology through quality mentoring and training opportunities for advanced research skills and enhanced interdisciplinary knowledge in relevant content areas. Moreover, the proposed translational research is highly novel and will contribute to knowledge of biopsychosocial parenting processes in the perinatal period, particularly among high-risk mothers.

项目概要/摘要 儿童虐待构成严重的公共卫生危机，造成毁灭性的终生损失， 包括精神病理学1,2和药物滥用的风险增加，3社会情感功能较差，4,5 认知功能受损、6,7 教育程度较低、8 以及身体健康问题 9，例如心脏 疾病、10 肥胖、11 甚至早逝。 12 至关重要的是，儿童虐待的有害成本并没有被忽视。 仅限于直接受影响的人，但也可能通过养育方式中断和影响而蔓延到后代 13 因此，识别可以解释不同护理之间关联的干预机制 虐待历史和下一代的养育方式可以为这一领域的研究和理论提供依据 阐明临床实践中有意义的干预点。拟议的长期目标 该项目是检查多系统生理应激反应指标作为关联的中介 母亲虐待史与围产期育儿之间的关系。这个的新颖之处 项目是双重的。首先，该项目将检查下丘脑-垂体-肾上腺反应性（目标 1）和 副交感神经系统反应性（目标 2）作为虐待和养育之间的干预联系 在关键的发展时期。这是第一项检查多种生理介质的研究 这一关联同时进行，也是第一项专门检查副交感神经反应性的研究。 其次，该项目以特定领域的养育方法14为基础，提供了急需的特异性 保护和互惠方面的生理学和养育结果之间的差异关联 域。这项工作通过利用现有的前瞻性、纵向、 针对多样化、低收入女性的研究（n=85）。申请人的专业研究人员指导团队 将促进申请人在这一重要研究领域的发展。最后，本次获奖及完成 该项目将极大地帮助为发展领域有前途的年轻科学家提供强有力的研究培训 通过优质指导研究精神病理学、代际传递过程和人类生理学 以及高级研究技能和增强相关跨学科知识的培训机会 内容领域。此外，所提出的转化研究非常新颖，将有助于了解 围产期的生物心理社会养育过程，特别是高危母亲。