Administrative Core

行政核心

• 批准号: 10663222
• 负责人: SUZANNE CRAFT
• 金额: $ 38.68万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663222
• 关键词: Achievement; Action Research; Advisory Committees; Alzheimer' s Disease; Alzheimer' s disease related dementia; Animal Welfare; Area; Award; Blood Vessels; Clinical; Clinical Sciences; Collaborations; Communities; Consultations; Creativeness; Data; Dementia; Development; Education; Ensure; Ethics; Feedback; Fostering; Goals; Growth; Infrastructure; Institution; Interdisciplinary Education; Interdisciplinary Study; Lead; Leadership; Metabolic; Mission; Nature; Participant; Performance; Phenotype; Policies; Process; Program Evaluation; Regulation; Research; Research Personnel; Resources; Risk; Role; Series; Services; Specimen; Translational Research; Universities; Vision; Work; career; data management; disease heterogeneity; forest; health disparity; human subject; imaging biomarker; innovation; member; model design; neuropathology; normal aging; novel; programs; repository; success; translational model; translational scientist; trial design; vascular factor

Administrative Core – Project Summary The Wake Forest Alzheimer’s Disease Research Center (WF ADRC) provides a comprehensive, integrated infrastructure to facilitate research aimed at identifying the causes of AD, and elucidating the role of vascular/metabolic factors in transitions from normal aging to AD and other dementias. The WF ADRC also provides resources to better understand disease heterogeneity and the multi-faceted impact of health disparities on AD risk. The Administrative Core ensures that ADRC scientific and programmatic goals are achieved by providing visionary oversight and effective governance to all Center activities, and scientific direction to the Center as a whole. The Core will be directed by an Executive Committee, whose members include the Director, Associate Directors, Core and Service Leaders, and the Program Manager. The Executive Committee will be guided by an Internal Advisory Committee (IAC) composed of institutional leaders who meet regularly to facilitate the achievement of ADRC aims and promote the growth of AD research at WF. The Core will be also guided by an External Advisory Committee (EAC), chosen in consultation with the NIA and consisting of members of other ADRCs and scientific leaders. The EAC will meet annually to review WF ADRC program goals and progress. We will also seek input about ADRC engagement with our community and participants through our Community and Participant Advisory Boards. Expansion of AD-related research and impactful utilization of valuable scientific resources are important goals for all ADRCs. The Administrative Core Committee for Resource Utilization and Research EXpansion (CRUX) oversees a coordinated series of activities to ensure that ADRC resources contribute to high-impact research and that new translational scientists are brought into the field. In the past cycle, the CRUX facilitated the rapid and successful integration of our new ADRC into the larger ADRC network, providing data and biospecimen resources to the National Alzheimer’s Coordinating Center (NACC), the National Centralized Repository for AD (NCRAD), other ADRCs and AD investigators world-wide. Through its distinctive theme and innovative phenotyping, our ADRC contributes to National Alzheimer’s Project Act (NAPA) Research Milestones involving metabolic/vascular factors, health disparities, translational models and trial design. WF ADRC’s ability to achieve its scientific and educational mission depends on the efficacy of its Administrative Core. In its inaugural cycle, Core leaders developed and led vigorous interdisciplinary research and educational programs. We have established effective Executive and Internal Advisory Committees, launched a successful pilot program that has drawn creative new investigators to AD research, and established multiple high-impact collaborations. Our comprehensive activities to date demonstrate that Administrative Core members have the vision, influence, and commitment to ensure the far-reaching success of the WF ADRC.

行政核心 - 项目摘要 维克森林阿尔茨海默氏病研究中心（WF ADRC）提供了全面的，整合的 基础设施促进旨在确定AD原因的研究，并阐明 从正常衰老到AD和其他痴呆症的过渡中的血管/代谢因子。 WF ADRC也 提供资源以更好地理解疾病异质性和健康的多方面影响 广告风险的差异。行政核心确保ADRC科学和程序化目标是 通过为所有中心活动提供有远见的监督和有效的治理来实现 整体中心的方向。核心将由执行委员会指导，其成员 包括董事，副董事，核心和服务负责人以及计划经理。 执行委员会将由内部咨询委员会（IAC）指导，该委员会由机构组成 定期开会以促进ADRC目标并促进广告发展的领导者 WF的研究。核心还将受到外部咨询委员会（EAC）的指导 与NIA协商，由其他ADRC和科学领导者的成员组成。 EAC会 每年开会以审查WF ADRC计划目标和进度。我们还将寻求有关ADRC的意见 通过我们的社区和参与者咨询委员会与我们的社区和参与者互动。 扩展与广告相关的研究和有影响力的有价值科学资源的利用很重要 所有ADRC的目标。资源利用与研究扩展的行政核心委员会 （CRUX）监督一系列协调的活动，以确保ADRC资源有助于高影响力 研究和新翻译的科学家被带入该领域。在过去的周期中，症结已准备就绪 我们的新ADRC快速而成功地集成到较大的ADRC网络中，提供数据和 国家阿尔茨海默氏症协调中心（NACC），国家集中式的生物循环资源 全球其他ADRC和AD调查人员的AD存储库（NCRAD）。通过其独特的主题和 创新的表型，我们的ADRC为国家阿尔茨海默氏症的项目法（NAPA）研究做出了贡献 涉及代谢/血管因素，健康差异，翻译模型和试验设计的里程碑。 WF ADRC实现其科学和教育使命的能力取决于其效率 行政核心。在首届周期中，核心领导者发展并领导了有力的跨学科研究 和教育计划。我们已经成立了有效的执行和内部咨询委员会， 启动了一项成功的试点计划，该计划吸引了创造性的新调查人员进行广告研究，并建立了 多次高影响合作。迄今为止，我们的全面活动证明了行政核心 成员具有确保WF ADRC取得深远的成功的愿景，影响力和承诺。