Alzheimer's Disease Research Center

阿尔茨海默病研究中心

基本信息

批准号：
10663221
负责人：
SUZANNE CRAFT
金额：
$ 305.1万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-15 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10663221
关键词：
Address Adult African American African American population Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk American Amyloid Area Biological Markers Blood Vessels Capsicum Clinical Clinical Sciences Clinical Trials Cognition Collaborations Communities Complex Data Dementia Diabetes Mellitus Dimensions Disease Doctor of Philosophy Early Intervention Ecosystem Education Elderly Enrollment Ensure Epidemic Faculty Faculty Recruitment Family Foundations Functional disorder Funding General Population Goals Grant Health Professional Heterogeneity High Prevalence Human Hypertension Impaired cognition Infrastructure Institution Intervention Trial Leadership Magnetic Resonance Imaging Medical Metabolic Metabolic Diseases Methods Mission Modeling Neurosciences Participant Patient Education Patients Phase Transition Play Positron-Emission Tomography Prediabetes syndrome Predictive Factor Prevalence Prevention Prevention strategy Publications Reduce health disparities Research Research Activity Research Infrastructure Research Personnel Resources Risk Risk Factors Role Sampling Statistical Data Interpretation Strategic Planning Symptoms Testing Training Translational Research Underrepresented Populations Vascular Diseases Work behavioral neurology clinical center clinical implementation cohort data management disease heterogeneity education research experience forest health disparity health equity imaging biomarker innovation investigator training medical schools neuroimaging neuropathology nonhuman primate normal aging novel novel strategies outreach prevent preventive intervention programs recruit repository resilience symptom treatment tau Proteins translational pipeline vascular factor vascular risk factor

项目摘要

Overall – Project Summary The Alzheimer’s Disease Research Center (ADRC) was founded at Wake Forest School of Medicine (WFSM) in 2016 to provide a comprehensive infrastructure for research on the pathophysiology, prevention, and treatment of AD and related disorders (ADRD). The theme of our ADRC is to better understand early transitions from normal aging to MCI and dementia, and to elucidate the role that metabolic and vascular factors play in these transitions, through coordinated research activities spanning the translational spectrum. No current therapies effectively prevent or treat the symptoms of AD. This chasm highlights the need to identify antecedent biomarkers and risk factors that predict later-life vulnerability or resilience, in order to develop strategies for prevention and early intervention. Metabolic and vascular disorders are powerful modifiable factors that may contribute to the transitions from normal aging to MCI and ADRD. Such disorders are epidemic in the Southeastern region surrounding the WF ADRC; more than 70% of adults over the age of 50 have prediabetes, diabetes, or hypertension. These disorders increase the risk of cognitive impairment and dementia through complex interactions that are poorly understood. The WF ADRC seeks to provide resources to better understand these interactions. We also seek to elucidate the multi-dimensional role that health disparities play in influencing risk for AD. We emphasize engagement of African Americans and other underrepresented groups, who are twice as likely to develop dementia, and have high rates of diabetes and vascular disease. To promote innovative research on metabolic/vascular risk and health disparities, our Outreach, Recruitment and Engagement and Clinical Cores have partnered to enroll and follow ~600 participants, carefully characterizing their vascular and glycemic status. Participants receive magnetic resonance imaging and amyloid and tau positron emission tomography overseen by the Imaging Biomarker Core. Valuable samples and data from this cohort are made widely available to the National Alzheimer’s Coordinating Center, the National Centralized Repository for AD and other investigators by the Data Management and Statistical Analysis and Neuropathology Cores, providing invaluable resources to address numerous National Alzheimer’s Project Act milestones. The Neuropathology Core has also characterized novel nonhuman primate models with methods that parallel the ADRC’s human cohort to promote translational research. Finally, the ADRC and its Research Education Component provide training relating to AD, metabolic/ vascular factors and health disparities to a diverse cadre of new researchers, and education for patients and families, health professionals, and the community. The prevalence of metabolic and vascular risk factors, their role in onset, progression, and heterogeneity of ADRDs, and the strengths of the WF ADRC in these research areas, ensure that we will make high-impact contributions to the search for strategies to treat and prevent AD.

总体 - 项目摘要阿尔茨海默氏病研究中心（ADRC）成立于维克森林医学院（WFSM） 2016年，为病理生理学，预防和研究提供了全面的基础设施 AD和相关疾病的治疗（ADRD）。我们的ADRC的主题是更好地理解从正常衰老到MCI和痴呆症的过渡，并阐明了代谢和血管的作用这些因素通过跨越翻译谱的协调研究活动在这些转变中发挥作用。当前的疗法没有有效预防或治疗AD的症状。这种鸿沟强调了识别的需要为了发展的前期生物标志物和危险因素，以发展预防和早期干预策略。代谢和血管疾病是可改变的可能导致从正常衰老到MCI和ADRD的过渡的因素。这样的疾病是 WF ADRC周围的东南地区流行； 50岁以上的成年人中有70％以上患有糖尿病前，糖尿病或高血压。这些疾病增加了认知障碍和痴呆通过复杂的相互作用，这些相互作用知之甚少。 WF ADRC试图提供资源更好地理解这些互动。我们还寻求阐明健康的多维作用差距会影响AD风险。我们强调非裔美国人和其他代表性不足的群体，患痴呆症的可能性是糖尿病率高的两倍，并且血管疾病。为了促进有关代谢/血管风险和健康分布的创新研究，我们外展，招聘和参与以及临床核心已合作参加并关注约600 参与者仔细地表征了他们的血管和血糖状态。参与者会收到磁性共振成像，淀粉样蛋白和tau极性发射断层扫描由成像生物标志物监督核。该队列中的有价值的样本和数据已广泛可用于国家阿尔茨海默氏症通过数据协调中心，全国集中式广告集中库和其他研究人员管理和统计分析和神经病理学核心，提供宝贵的资源来解决许多国家阿尔茨海默氏症的项目ACT里程碑。神经病理学核心还表征了小说非人类灵长类动物模型，其方法与ADRC的人类队列相似，以促进翻译研究。最后，ADRC及其研究教育部分提供了与AD，代谢/ 新研究人员的多样性干部的血管因素和健康差异，以及针对患者的教育以及家庭，卫生专业人员和社区。代谢和血管危险因素的流行率 ADRD的发作，进展和异质性以及WF ADRC的优势在这些研究中的作用区域，确保我们将为寻找治疗和预防广告的策略做出高影响力的贡献。

项目成果

期刊论文数量（46）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Incidence of Dementia Following Hospitalization With Infection Among Adults in the Atherosclerosis Risk in Communities (ARIC) Study Cohort.

DOI：
10.1001/jamanetworkopen.2022.50126
发表时间：
2023-01-03
期刊：
JAMA NETWORK OPEN
影响因子：
13.8
作者：
Bohn, Bruno;Lutsey, Pamela L.;Misialek, Jeffrey R.;Walker, Keenan A.;Brown, Charles H.;Hughes, Timothy M.;Ishigami, Junichi;Matsushita, Kunihiro;Demmer, Ryan T.
通讯作者：
Demmer, Ryan T.

Intranasal insulin modulates cerebrospinal fluid markers of neuroinflammation in mild cognitive impairment and Alzheimer's disease: a randomized trial.

DOI：
10.1038/s41598-022-05165-3
发表时间：
2022-01-25
期刊：
Scientific reports
影响因子：
4.6
作者：
Kellar D;Register T;Lockhart SN;Aisen P;Raman R;Rissman RA;Brewer J;Craft S
通讯作者：
Craft S

Virtual delivery of improvisational movement and social engagement interventions in the IMOVE trial during the COVID-19 pandemic.

DOI：
10.1016/j.conctc.2023.101102
发表时间：
2023-06
期刊：
Contemporary clinical trials communications
影响因子：
1.5
作者：
通讯作者：

Hypertensive Aspects of Cardiometabolic Disorders Are Associated with Lower Brain Microstructure, Perfusion, and Cognition.

DOI：
10.3233/jad-220646
发表时间：
2022
期刊：
JOURNAL OF ALZHEIMERS DISEASE
影响因子：
4
作者：
Hughes, Timothy M.;Lockhart, Samuel N.;Suerken, Cynthia K.;Jung, Youngkyoo;Whitlow, Christopher T.;Bateman, James R.;Williams, Benjamin J.;Espeland, Mark A.;Sachs, Bonnie C.;Williamson, Jeff;Cleveland, Maryjo;Yang, Mia;Rogers, Samantha;Hayden, Kathleen M.;Baker, Laura D.;Craft, Suzanne
通讯作者：
Craft, Suzanne

Cerebral insulin receptors: a nexus for vascular and metabolic contributions to Alzheimer's disease.

大脑胰岛素受体：血管和代谢与阿尔茨海默氏病的关系。