Administrative Core

行政核心--项目摘要 维克森林阿尔茨海默氏症研究中心(WF ADRC)提供全面、综合的 基础设施，以促进旨在确定AD原因和阐明AD的作用的研究 从正常衰老到AD和其他痴呆转变中的血管/代谢因素。WF ADRC还 提供资源，以更好地了解疾病的异质性和健康的多方面影响 AD风险的差异。行政核心确保ADRC的科学和方案目标是 通过为中心的所有活动提供有远见的监督和有效的治理，以及科学的 作为一个整体指向中心的方向。核心将由一个执行委员会领导，其成员 包括总监、副总监、核心和服务负责人以及项目经理。这个 执行委员会将由内部咨询委员会(IAC)指导，该委员会由以下机构组成 定期会晤以促进实现ADRC目标并促进AD增长的领导人 WF的研究。核心还将由一个外部咨询委员会(EAC)指导，该委员会由#年选出 与NIA协商，并由其他ADRC成员和科学领袖组成。选管会将 每年召开会议，审查WF ADRC计划的目标和进展。我们还将征求有关ADRC的意见 通过我们的社区和参与者咨询委员会与我们的社区和参与者进行接触。 扩大AD相关研究和有效利用宝贵的科学资源是重要的 所有ADRC的目标。资源利用和研究扩展行政核心委员会 (关键问题)监督一系列协调一致的活动，以确保红十字与红新月会的资源有助于提高影响力 研究和新的翻译科学家被带入该领域。在过去的周期中，症结在于 我们的新ADRC迅速并成功地集成到更大的ADRC网络中，提供数据和 向国家阿尔茨海默氏症协调中心(NACC)提供生物胺资源 AD储存库(NCRAD)、其他ADRC和世界各地的AD调查人员。通过其独特的主题和 创新的表型，我们的ADRC为国家阿尔茨海默氏症项目法案(NAPA)研究做出了贡献 涉及代谢/血管因素、健康差异、转换模型和试验设计的里程碑。 WF ADRC实现其科学和教育使命的能力取决于其 管理核心。在其成立周期中，核心领导者开发并领导了强有力的跨学科研究 和教育项目。我们设立了有效的执行和内部咨询委员会， 启动了一个成功的试点计划，吸引了富有创造力的新调查人员参与AD研究，并建立了 多个高影响力的协作。到目前为止，我们的全面活动证明了行政核心 成员们有远见、影响力和承诺来确保WF ADRC取得深远的成功。

Administrative Core – Project Summary The Wake Forest Alzheimer’s Disease Research Center (WF ADRC) provides a comprehensive, integrated infrastructure to facilitate research aimed at identifying the causes of AD, and elucidating the role of vascular/metabolic factors in transitions from normal aging to AD and other dementias. The WF ADRC also provides resources to better understand disease heterogeneity and the multi-faceted impact of health disparities on AD risk. The Administrative Core ensures that ADRC scientific and programmatic goals are achieved by providing visionary oversight and effective governance to all Center activities, and scientific direction to the Center as a whole. The Core will be directed by an Executive Committee, whose members include the Director, Associate Directors, Core and Service Leaders, and the Program Manager. The Executive Committee will be guided by an Internal Advisory Committee (IAC) composed of institutional leaders who meet regularly to facilitate the achievement of ADRC aims and promote the growth of AD research at WF. The Core will be also guided by an External Advisory Committee (EAC), chosen in consultation with the NIA and consisting of members of other ADRCs and scientific leaders. The EAC will meet annually to review WF ADRC program goals and progress. We will also seek input about ADRC engagement with our community and participants through our Community and Participant Advisory Boards. Expansion of AD-related research and impactful utilization of valuable scientific resources are important goals for all ADRCs. The Administrative Core Committee for Resource Utilization and Research EXpansion (CRUX) oversees a coordinated series of activities to ensure that ADRC resources contribute to high-impact research and that new translational scientists are brought into the field. In the past cycle, the CRUX facilitated the rapid and successful integration of our new ADRC into the larger ADRC network, providing data and biospecimen resources to the National Alzheimer’s Coordinating Center (NACC), the National Centralized Repository for AD (NCRAD), other ADRCs and AD investigators world-wide. Through its distinctive theme and innovative phenotyping, our ADRC contributes to National Alzheimer’s Project Act (NAPA) Research Milestones involving metabolic/vascular factors, health disparities, translational models and trial design. WF ADRC’s ability to achieve its scientific and educational mission depends on the efficacy of its Administrative Core. In its inaugural cycle, Core leaders developed and led vigorous interdisciplinary research and educational programs. We have established effective Executive and Internal Advisory Committees, launched a successful pilot program that has drawn creative new investigators to AD research, and established multiple high-impact collaborations. Our comprehensive activities to date demonstrate that Administrative Core members have the vision, influence, and commitment to ensure the far-reaching success of the WF ADRC.