Administrative Core

管理核心-项目摘要 维克森林阿尔茨海默病研究中心（WF ADRC）提供了一个全面的，综合的 基础设施，以促进研究，旨在确定AD的原因，并阐明 血管/代谢因素在从正常衰老到AD和其他痴呆的转变中的作用。WF ADRC还 提供资源，以更好地了解疾病的异质性和健康的多方面影响 AD风险的差异。行政核心确保ADRC的科学和方案目标 通过对中心的所有活动提供有远见的监督和有效的治理， 向中心整体发展。该核心将由一个执行委员会领导，其成员 包括主任、副主任、核心和服务领导人以及项目经理。的 执行委员会将由一个内部咨询委员会（IAC）指导， 定期开会的领导人，以促进ADRC目标的实现和促进AD的发展 研究在WF。核心小组还将接受一个外部咨询委员会的指导，该委员会是在 与NIA协商，由其他ADRC成员和科学领导人组成。选管会将 每年召开一次会议，审查WF ADRC计划的目标和进展情况。我们亦会寻求有关自抗检讨委员会的意见 通过我们的社区和参与者咨询委员会与我们的社区和参与者互动。 扩大AD相关研究和有效利用宝贵的科学资源非常重要 所有ADRC的目标。资源利用和研究扩展行政核心委员会 （CRUX）监督一系列协调一致的活动，以确保ADRC的资源有助于产生高影响力。 研究和新的翻译科学家被带入该领域。在过去的周期中，CRUX促进了 快速和成功地将我们的新ADRC集成到更大的ADRC网络中，提供数据和 生物标本资源的国家阿尔茨海默氏症协调中心（NACC），国家集中 AD（NCRAD）、其他ADRC和全球AD研究者的资料库。通过其独特的主题和 创新的表型，我们的ADRC有助于国家阿尔茨海默病项目法案（NAPA）研究 涉及代谢/血管因素、健康差异、转化模型和试验设计的糖尿病。 WF ADRC实现其科学和教育使命的能力取决于其 行政核心。在其成立之初，核心领导人开发和领导了充满活力的跨学科研究 和教育项目。我们设立了有效的执行和内部咨询委员会， 启动了一项成功的试点计划，吸引了富有创造力的新研究人员参与AD研究，并建立了 多个高影响力的合作。我们迄今为止的全面活动表明， 成员有远见，影响力，并承诺确保WF ADRC的深远成功。

Administrative Core – Project Summary The Wake Forest Alzheimer’s Disease Research Center (WF ADRC) provides a comprehensive, integrated infrastructure to facilitate research aimed at identifying the causes of AD, and elucidating the role of vascular/metabolic factors in transitions from normal aging to AD and other dementias. The WF ADRC also provides resources to better understand disease heterogeneity and the multi-faceted impact of health disparities on AD risk. The Administrative Core ensures that ADRC scientific and programmatic goals are achieved by providing visionary oversight and effective governance to all Center activities, and scientific direction to the Center as a whole. The Core will be directed by an Executive Committee, whose members include the Director, Associate Directors, Core and Service Leaders, and the Program Manager. The Executive Committee will be guided by an Internal Advisory Committee (IAC) composed of institutional leaders who meet regularly to facilitate the achievement of ADRC aims and promote the growth of AD research at WF. The Core will be also guided by an External Advisory Committee (EAC), chosen in consultation with the NIA and consisting of members of other ADRCs and scientific leaders. The EAC will meet annually to review WF ADRC program goals and progress. We will also seek input about ADRC engagement with our community and participants through our Community and Participant Advisory Boards. Expansion of AD-related research and impactful utilization of valuable scientific resources are important goals for all ADRCs. The Administrative Core Committee for Resource Utilization and Research EXpansion (CRUX) oversees a coordinated series of activities to ensure that ADRC resources contribute to high-impact research and that new translational scientists are brought into the field. In the past cycle, the CRUX facilitated the rapid and successful integration of our new ADRC into the larger ADRC network, providing data and biospecimen resources to the National Alzheimer’s Coordinating Center (NACC), the National Centralized Repository for AD (NCRAD), other ADRCs and AD investigators world-wide. Through its distinctive theme and innovative phenotyping, our ADRC contributes to National Alzheimer’s Project Act (NAPA) Research Milestones involving metabolic/vascular factors, health disparities, translational models and trial design. WF ADRC’s ability to achieve its scientific and educational mission depends on the efficacy of its Administrative Core. In its inaugural cycle, Core leaders developed and led vigorous interdisciplinary research and educational programs. We have established effective Executive and Internal Advisory Committees, launched a successful pilot program that has drawn creative new investigators to AD research, and established multiple high-impact collaborations. Our comprehensive activities to date demonstrate that Administrative Core members have the vision, influence, and commitment to ensure the far-reaching success of the WF ADRC.