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TRD 1 - Imaging Cancer Heterogeneity

TRD 1 - 癌症异质性成像

基本信息

批准号：
10540777
负责人：
Nathalie YR Agar
金额：
$ 38.57万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-06 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10540777
关键词：
3-Dimensional Address Agar Architecture Biopsy Blood Brain Mapping Brain Neoplasms Categories Cells Characteristics Clinical Data Clinical Management Complement Data Dedications Development Diagnosis Diagnostic Procedure Diffusion Doctor of Philosophy Effectiveness Environment Evaluation Failure Female Genital Neoplasms Frozen Sections Future Gene Expression Genotype Gland Goals Heterogeneity Histopathology Hypoxia Image Imaging technology Individual Knowledge Location Magnetic Resonance Magnetic Resonance Imaging Malignant Neoplasms Malignant neoplasm of cervix uteri Malignant neoplasm of prostate Maps Measurement Mediating Metabolic Metabolic Marker Metabolism Methods Microscopic Molecular Nature Operative Surgical Procedures Oxygen Patient Care Patients Phenotype Physiologic pulse Plague Procedures Prostatic Neoplasms Protocols documentation Radiation therapy Reproducibility Risk Assessment Role Sampling Signal Transduction Specimen Spectrometry Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Speed T2 weighted imaging Techniques Technology Testing Therapeutic Agents Time Management Tissue imaging Tissues Translating Tumor Burden Tumor Volume cancer heterogeneity cancer imaging cancer therapy chemotherapy correctional system data analysis pipeline deep learning design dosage genetic makeup high dimensionality image guided image guided therapy imaging facilities improved individualized medicine instrument ion mobility machine learning method mass spectrometer mass spectrometric imaging men metabolic profile metabolomics neoplastic cell novel novel strategies overtreatment personalized medicine precision medicine prostate biopsy prostate lesions protocol development radiomics respiratory challenge targeted imaging targeted treatment technology platform technology validation tissue oxygenation trait treatment planning tumor tumor heterogeneity tumor hypoxia ultra high resolution

项目摘要

Project Summary TRD 1: Imaging Cancer Heterogeneity Precision medicine is a paradigm shift whereby personalized treatment approaches are based on knowledge of an individual’s genotype and phenotype. While it is important to match the therapeutic agents to the genetic makeup of a tumor, new strategies are needed to detect and optimally characterize the imaging phenotype of tumors and definitively determine the tumor/no tumor borders to optimize patient-specific treatments. As such, the role of imaging in assessing tumor heterogeneity and accurately characterizing those who will require definitive therapy is critical. Using image guidance for precise mapping of tumor cell composition and accurate 3D mapping of brain, prostate, and gynecological tumor burden is the best approach to characterizing tumors and guiding clinical management at diagnosis. The goal of the Imaging Cancer Heterogeneity TRD is to develop and validate molecular, micro- and macroscale imaging technologies to characterize the macroscopic and microscopic environment of tumors, tumor heterogeneity and tumor volume, and improve risk assessment to guide the precise treatment of cancer. While the initial studies will focus on brain, prostate, and gynecological neoplasms, we envision the technology and findings derived from this TRD will be broadly applicable to a variety of cancers. Hence, the aims are designed to provide novel and detailed mapping of tumor heterogeneity and define tumor borders using mass spectrometry imaging (MSI) correlated with histopathology and multiparametric MRI technologies.

项目摘要 TRD 1：成像癌症异质结精准医疗是一种范式转变，个性化治疗方法基于对以下方面的了解：个体的基因型和表现型。虽然重要的是将治疗剂与遗传因子相匹配，肿瘤的组成，需要新的策略来检测和最佳地表征肿瘤的成像表型。肿瘤和明确确定肿瘤/无肿瘤边界，以优化患者特异性治疗。因此，在本发明的一个方面，成像在评估肿瘤异质性和准确描述那些需要决定性的治疗至关重要。利用图像引导精确绘制肿瘤细胞组成，脑、前列腺和妇科肿瘤负荷的3D映射是表征肿瘤的最佳方法并在诊断时指导临床管理。成像癌症异质结TRD的目标是开发和验证分子，微观和宏观尺度成像技术来表征肿瘤的宏观和微观环境，肿瘤异质性和肿瘤体积，并改善风险评估，以指导癌症的精确治疗。虽然最初的研究将集中在脑，前列腺和妇科肿瘤，我们设想的技术从TRD中得出的发现将广泛适用于各种癌症。因此，目标是旨在提供肿瘤异质性的新的和详细的映射，并使用质量定义肿瘤边界光谱成像（MSI）与组织病理学和多参数MRI技术相关。