Boston Latino Aging Study (BLAST): Understanding Alzheimer's risk and biomarkers in older Latinos
波士顿拉丁裔老龄化研究 (BLAST):了解老年拉丁裔的阿尔茨海默病风险和生物标志物
基本信息
- 批准号:10540408
- 负责人:
- 金额:$ 83.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-01-01 至 2025-12-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdministrative SupplementAgingAlzheimer associated neurodegenerationAlzheimer&aposs DiseaseAlzheimer&aposs disease diagnosisAlzheimer&aposs disease pathologyAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAmyloidAmyloid beta-ProteinBiological MarkersBostonBrainBrain PathologyCardiovascular DiseasesChronic stressCognitionCognitiveCommunitiesDementiaDevelopmentDiabetes MellitusEarly DiagnosisElderlyEligibility DeterminationEnrollmentExhibitsFunctional Magnetic Resonance ImagingFundingGoalsGrantHigh PrevalenceHypertensionImageImpaired cognitionIndividualInterventionKnowledgeLatinoLatino PopulationLinkMassachusettsMeasuresMemoryMoodsNerve DegenerationOnset of illnessParticipantPathologyPatient Self-ReportPhysical activityPopulationPositron-Emission TomographyPrevalencePreventionRegistriesResearchRestRiskRisk FactorsRisk MarkerSleepSleep disturbancesTimeVisitWorkaffective disturbanceaging brainamyloid pathologycardiovascular risk factorcognitive performancecohortdementia riskdesignfollow-upgood dietimprovedin vivolife-long learningmiddle agemodifiable riskmolecular markernetwork dysfunctionneuroimagingnon-dementednormal agingnovelpre-clinicalpreventive interventionrecruittau Proteins
项目摘要
Latinos are the fastest growing subpopulation of older adults in the U.S.A. and have a greater prevalence of
Alzheimer’s disease (AD) than non-Latino whites (1). Despite this, our knowledge of normal aging, cognitive
decline, and AD-related neurodegeneration in Latinos is sparse. A growing body of evidence supports a link
between AD onset and several modifiable factors, some of which convey risk (e.g., mid-life hypertension, sleep
and mood distrurbance). Other factors are considered protective, such as engaging in regular physical activity,
managing cardiovascular risk factors (i.e., diabetes, obesityand hypertension), maintaining a healthy diet, and
engaging in lifelong learning (2). It is also known that some of these modifiable risk factors have a higher
prevalence in Latinos, compared to non-Latinos (3). Nonetheless, how these factors independently or
interactively make older Latinos more vulnerable to accumulation of AD pathology, cognitive decline, and
dementia remains unclear. Thus, investigating the impact of different AD risk factors on cognition, brain
function, and AD molecular markers of pathology in older Latinos is pivotal to improving prevention,
early detection, and development of novel treatments and interventions for this critically underserved
and understudied population.
To promote recruitment and participation of Latinos in biomarker and aging research, we initiated a registry
of older community-dwelling Latinos living in Massachusetts (known as the Boston Latino Aging Registry).
Furthermore, with the support of an administrative supplement in 2019 we began to include more Latino
participants in the ongoing NIA-funded Harvard Aging Brain Study, which is now known as Latino HABS. We
propose to build upon these previous recruitment efforts to study aging and preclinical AD in non-demented
older Latinos and non-Latino White individuals. All participants will undergo a comprehensive assessment of
cognition, amyloid and tau PET scanning, as well as structural and resting fMRI. They will also complete self-
report measures of modifiable dementia risk factors (e.g. cardiovascular disease, sleep, mood), all of which will
be used to create an overall dementia risk score. Comparisons between Latinos and non-Latinos will be made
in all aims with the goal of using the findings to validate and inform biomarker findings in older Latinos.
Our ultimate goal is to build a cohort of older Latinos that we can be followed up overtime. For the current
R01 grant, we propose to enroll a total of 200 older community dwelling individuals (60-80 years; 150 Latinos
and 50 non-Latinos) and compare them to 200 already enrolled in HABS (60-80 years; 150 non-Latinos and 50
Latinos) to 1) investigate modifiable dementia risk factors and cognition in older Latinos and non-Latinos; 2)
examine modifiable dementia risk factors and memory network dysfunction in older Latinos and non-Latinos;
and 3) examine the associations between modifiable dementia risk factors and markers of brain pathology in
older Latinos and non-Latinos.
拉丁裔是美国老年人中增长最快的亚群,
阿尔茨海默病(AD)比非拉丁裔白人(1)。尽管如此,我们对正常衰老的认识,
下降,拉丁美洲人中AD相关的神经退行性变很少。越来越多的证据表明
AD发作与几个可改变的因素之间的关系,其中一些因素传递风险(例如,中年高血压,睡眠
和情绪紊乱)。其他因素也被认为是保护性的,比如经常参加体育活动,
管理心血管风险因素(即,糖尿病、肥胖症和高血压),保持健康饮食,
终身学习(2)。还已知这些可改变的风险因素中的一些具有较高的
与非拉丁美洲人相比,拉丁美洲人的患病率(3)。然而,这些因素如何独立或
交互式地使老年拉丁美洲人更容易受到AD病理学、认知能力下降和
痴呆症仍不清楚。因此,研究不同的AD危险因素对认知、脑功能和神经功能的影响,
功能,和老年拉丁美洲人的AD病理分子标志物是改善预防的关键,
早期发现,并开发新的治疗和干预措施,
被忽视的人群
为了促进招募和参与生物标志物和衰老研究的拉丁美洲人,我们启动了一项登记研究,
居住在马萨诸塞州的老年社区居住的拉丁美洲人(称为波士顿拉丁美洲老龄化登记处)。
此外,在2019年行政补充的支持下,我们开始纳入更多的拉丁裔
参与者正在进行的国家情报局资助的哈佛老化大脑研究,这是现在被称为拉丁美洲HABS。我们
我建议在这些先前的招募工作的基础上,研究非痴呆患者的衰老和临床前AD。
拉丁裔和非拉丁裔白色人。所有参与者将接受全面评估,
认知,淀粉样蛋白和tau PET扫描,以及结构和静息功能磁共振成像。他们也将完成自我-
报告可改变的痴呆症风险因素(如心血管疾病,睡眠,情绪)的措施,所有这些都将
用于创建整体痴呆风险评分。将对拉丁美洲人和非拉丁美洲人进行比较
在所有的目的,目的是利用这些发现来验证和告知生物标志物的发现在老年拉丁美洲人。
我们的最终目标是建立一个老年拉丁美洲人的队列,我们可以跟踪加班。为当前
R 01补助金,我们建议招募200名老年社区居民(60-80岁; 150名拉丁裔
和50名非拉丁美洲人),并将他们与200名已经参加HABS的人(60-80岁; 150名非拉丁美洲人和50名非拉丁美洲人)进行比较。
1)调查老年拉丁美洲人和非拉丁美洲人的可改变的痴呆风险因素和认知; 2)
检查老年拉丁裔和非拉丁裔中可改变的痴呆症风险因素和记忆网络功能障碍;
和3)检查可改变的痴呆风险因素和脑病理学标志物之间的关联,
拉丁美洲人和非拉丁美洲人。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Yakeel T. Quiroz其他文献
Demencia frontotemporal: variante temporal derecha, reporte de dos casos
额颞叶痴呆:颞叶痴呆,报告 casos
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
Laura Ramírez;Lina Velilla;Yakeel T. Quiroz;F. Lopera;Margarita Giraldo - 通讯作者:
Margarita Giraldo
Event-related potential correlates of recognition memory in asymptomatic individuals with CADASIL
- DOI:
10.1016/j.brainres.2018.11.016 - 发表时间:
2019-03-15 - 期刊:
- 影响因子:
- 作者:
Jorge Rendon;Yesica Zuluaga;Lina Velilla;Jhon Ochoa;Joseph F. Arboleda-Velasquez;Andrew Budson;Francisco Lopera;Yakeel T. Quiroz - 通讯作者:
Yakeel T. Quiroz
Resilience to autosomal dominant Alzheimer’s disease in a Reelin-COLBOS heterozygous man
Reelin-COLBOS 杂合子男性对常染色体显性阿尔茨海默病的抵抗力
- DOI:
10.1038/s41591-023-02318-3 - 发表时间:
2023-05-15 - 期刊:
- 影响因子:50.000
- 作者:
Francisco Lopera;Claudia Marino;Anita S. Chandrahas;Michael O‚ÄôHare;Nelson David Villalba-Moreno;David Aguillon;Ana Baena;Justin S. Sanchez;Clara Vila-Castelar;Liliana Ramirez Gomez;Natalia Chmielewska;Gabriel M. Oliveira;Jessica Lisa Littau;Kristin Hartmann;Kyungeun Park;Susanne Krasemann;Markus Glatzel;Dorothee Schoemaker;Lucia Gonzalez-Buendia;Santiago Delgado-Tirado;Said Arevalo-Alquichire;Kahira L. Saez-Torres;Dhanesh Amarnani;Leo A. Kim;Randall C. Mazzarino;Harper Gordon;Yamile Bocanegra;Andres Villegas;Xiaowu Gai;Moiz Bootwalla;Jianling Ji;Lishuang Shen;Kenneth S. Kosik;Yi Su;Yinghua Chen;Aaron Schultz;Reisa A. Sperling;Keith Johnson;Eric M. Reiman;Diego Sepulveda-Falla;Joseph F. Arboleda-Velasquez;Yakeel T. Quiroz - 通讯作者:
Yakeel T. Quiroz
Neural Correlates of Recognition Memory in Preclinical Young-Onset Dementia
- DOI:
10.1016/j.ijpsycho.2016.07.170 - 发表时间:
2016-10-01 - 期刊:
- 影响因子:
- 作者:
Yakeel T. Quiroz;Carlos Tobon;Claudia Muñoz;Rebecca Deason;Joshua McKeever;Lina Velilla;Joseph Arboleda-Velasquez;Francisco Lopera;Andrew Budson - 通讯作者:
Andrew Budson
Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment
基于智能手表和智能手机的大脑健康远程评估及轻度认知障碍检测
- DOI:
10.1038/s41591-024-03475-9 - 发表时间:
2025-03-04 - 期刊:
- 影响因子:50.000
- 作者:
Paul Monroe Butler;Jenny Yang;Roland Brown;Matt Hobbs;Andrew Becker;Joaquin Penalver-Andres;Philippe Syz;Sofia Muller;Gautier Cosne;Adrien Juraver;Han Hee Song;Paramita Saha-Chaudhuri;Daniel Roggen;Alf Scotland;Natalia Silveira;Gizem Demircioglu;Audrey Gabelle;Richard Hughes;Michael G. Erkkinen;Jessica B. Langbaum;Jennifer H. Lingler;Pamela Price;Yakeel T. Quiroz;Sharon J. Sha;Marty Sliwinski;Anton P. Porsteinsson;Rhoda Au;Matt T. Bianchi;Hanson Lenyoun;Hung Pham;Mithun Patel;Shibeshih Belachew - 通讯作者:
Shibeshih Belachew
Yakeel T. Quiroz的其他文献
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{{ truncateString('Yakeel T. Quiroz', 18)}}的其他基金
Boston Latino Aging Study (BLAST): Understanding Alzheimer's risk and biomarkers in older Latinos
波士顿拉丁裔老龄化研究 (BLAST):了解老年拉丁裔的阿尔茨海默病风险和生物标志物
- 批准号:
10322722 - 财政年份:2021
- 资助金额:
$ 83.96万 - 项目类别:
Relationship between tau pathology and cognitive impairment in autosomal dominant Alzheimer's disease
常染色体显性阿尔茨海默病中 tau 蛋白病理学与认知障碍的关系
- 批准号:
9383621 - 财政年份:2017
- 资助金额:
$ 83.96万 - 项目类别:
Relationship between tau pathology and cognitive impairment in autosomal dominant Alzheimer's disease
常染色体显性阿尔茨海默病中 tau 蛋白病理学与认知障碍的关系
- 批准号:
10164690 - 财政年份:2017
- 资助金额:
$ 83.96万 - 项目类别:
Memory network dysfunction as an early marker of preclinical Alzheimer's Disease
记忆网络功能障碍是临床前阿尔茨海默病的早期标志
- 批准号:
9188789 - 财政年份:2014
- 资助金额:
$ 83.96万 - 项目类别:
Memory network dysfunction as an early marker of preclinical Alzheimer's Disease
记忆网络功能障碍是临床前阿尔茨海默病的早期标志
- 批准号:
9349386 - 财政年份:2014
- 资助金额:
$ 83.96万 - 项目类别:
Memory network dysfunction as an early marker of preclinical Alzheimer's Disease
记忆网络功能障碍是临床前阿尔茨海默病的早期标志
- 批准号:
9142094 - 财政年份:2014
- 资助金额:
$ 83.96万 - 项目类别:
Structural and Functional Neuroanatomy of Memory in Familial Alzheimer's Disease
家族性阿尔茨海默病记忆的结构和功能神经解剖学
- 批准号:
8128054 - 财政年份:2011
- 资助金额:
$ 83.96万 - 项目类别:
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