Indoor Air Quality and Respiratory Morbidity in School-Aged Children with Bronchopulmonary Dysplasia

患有支气管肺发育不良的学龄儿童的室内空气质量和呼吸系统发病率

• 批准号: 10540413
• 负责人: JONATHAN MARK GAFFIN
• 金额: $ 72.26万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-15 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10540413
• 关键词: Acute; Adult; Affect; Air; Air Pollutants; Air Pollution; Allergens; Asthma; Bronchiolitis; Bronchopulmonary Dysplasia; Caring; Child; Child Health; Childhood; Childhood Asthma; Chronic; Chronic lung disease; Clinical; Clinical Research; Data; Development; Dictyoptera; Disease; Endotoxins; Environmental Exposure; Environmental Health; Epidemiology; Exclusion; Exposure to; Force of Gravity; Future; General Population; Gestational Age; Goals; Health; Home; Home environment; Humidity; Hypersensitivity; Impaired health; Impairment; Individual; Indoor Air Pollution; Indoor Air Quality; Indoor environment; Infant; Intervention; Intervention Studies; Irritants; Life; Literature; Lung diseases; Measures; Molds; Morbidity - disease rate; Mus; Neonatal; Neonatal Intensive Care Units; Nitrogen Dioxide; Outcome; Outcomes Research; Particulate Matter; Patients; Policy Maker; Pollution; Population; Populations at Risk; Predisposing Factor; Premature Infant; Prevalence; Productivity; Pulmonary Function Test/Forced Expiratory Volume 1; Recording of previous events; Research; Respiratory Disease; Respiratory Signs and Symptoms; Risk; Risk Factors; Role; Sampling; School-Age Population; Schools; Seasonal Variations; Severities; Smoking; Source; Subgroup; Symptoms; Temperature; Testing; Time; Vulnerable Populations; asthmatic; cohort; comorbidity; design; disability; epidemiology study; experience; fine particles; health care service utilization; high risk population; household environmental exposure; improved; indoor concentrations; indoor pollutant; modifiable risk; negative affect; pollutant; premature; prevent; pulmonary function; respiratory; respiratory health; respiratory morbidity; response

Project Summary/Abstract While the care of premature infants continues to improve survival for infants born at increasingly shorter gestational ages, there is no evidence that the rate of bronchopulmonary dysplasia (BPD), the most common chronic lung disease of prematurity, is significantly declining, leaving an overall growing population of children with substantial respiratory health impairment. Almost half of all school-aged children with BPD have asthma or asthma-like symptoms and more suffer long-term lung function abnormalities that put them on a trajectory of poor lung function in adulthood. Few studies have evaluated contributing factors to long-term respiratory mor- bidity, and, except smoking, there is an absence of data regarding post-neonatal intensive care unit (NICU) environmental influences. Air pollution and indoor respiratory irritants are known to cause respiratory symp- toms, decline in lung function, and are associated with healthcare utilization in several at-risk populations of children with chronic respiratory conditions, as well as, populations of healthy children. Therefore, identifying the impact these potentially-modifiable exposures have on the high rate of symptoms and lung function abnor- malities in this group is critically important to developing future interventions to improve the health of children with BPD. The overall objective of this study is to determine the contribution of indoor air quality and environmen- tal exposures in the home environment to respiratory morbidity in children with a history of BPD, the first step toward achieving the long-term research goal of producing targeted interventions to improve respiratory health in children with chronic lung diseases. The central hypothesis is that children with BPD suffer respiratory mor- bidity by exposure to air pollutants encountered inside the home environment, independent of allergens and other factors. This proposal details a five-year project to investigate the role of indoor environmental exposures on respiratory symptoms, and, separately, on lung function deficits in school-aged children with BPD. State-of-the- art measures of indoor air quality constituents will assess the relationship of nitrogen dioxide (NO2), particulate matter (PM2.5), as well as, concentrations of allergens (mold, mouse, cockroach, pet), endotoxin, air tempera- ture and humidity with concurrently measured respiratory symptoms and lung function in a well-characterized cohort of children with BPD. This research will identify specific harmful components of the indoor environment associated with respiratory morbidity and poor lung function in children with BPD, independent of neonatal BPD severity and other known epidemiologic risk factors. The impact of these findings will be to identify modi- fiable risk factors and identify future opportunities to test interventions that may improve the substantial respira- tory health burden suffered by this growing high-risk group of children with BPD throughout life.

项目总结/文摘

项目成果

Measuring adherence in paediatric asthma: Integrating pharmacy data into clinical care.

衡量小儿哮喘的依从性：将药房数据纳入临床护理。

• DOI: 10.1111/jep.13897
• 发表时间: 2024
• 期刊: Journal of evaluation in clinical practice
• 影响因子: 2.4
• 作者: Moreno-Galarraga,Laura;Gaffin,Jonathan;Simoneau,Tregony
• 通讯作者: Simoneau,Tregony

Health-Related Qualities of Life in School-Aged Children with Bronchopulmonary Dysplasia.

患有支气管肺发育不良的学龄儿童的健康相关生活质量。

• DOI: 10.1016/j.jpeds.2023.113548
• 发表时间: 2023
• 期刊: The Journal of pediatrics
• 作者: Sierra,Gabriella;Liu,JessicaP;Ith,Izabelle;Gudur,Divya;Cunningham,Deja;Dahlberg,SuzanneE;Beam,Kristyn;Gaffin,JonathanM
• 通讯作者: Gaffin,JonathanM

The Role of Comorbidities in Difficult-to-Control Asthma in Adults and Children.

• DOI: 10.1016/j.jaip.2021.11.016
• 发表时间: 2022-03
• 期刊: The journal of allergy and clinical immunology. In practice
• 作者: Gaffin JM;Castro M;Bacharier LB;Fuhlbrigge AL
• 通讯作者: Fuhlbrigge AL