Community-Engaged Research on COVID-19 Testing Among Underserved and/or Vulnerable Populations Phase II

项目摘要 COVID-19大流行在全球范围内造成了前所未有的公共卫生和经济后果， 在美国长期存在的社会不平等现象被放大，脆弱社区 受到大流行病的不成比例的负担。在佛罗里达的迈阿密-戴德县， 经历了高度的社会脆弱性，黑人和西班牙裔在COVID-19相关的 与全国住院率和死亡率相比。此外，迈阿密戴德县继续经历 COVID-19的发病率远高于州和全国水平。现在已经有了有效的疫苗，但疫苗 美国少数族裔的发病率一直较低，扩大了COVID-19结果的差异。作为 这种扩大的SARS-CoV-2检测和疫苗接受对于减缓 服务不足和弱势群体。在RADx-UP项目第二阶段的申请中，我们将申请 在第一阶段获得的知识，以扩大社区外展，以增加测试和疫苗的吸收， 少数族裔社区，以减少导致COVID-19负担的差距， 弱势群体。我们建议继续我们的RADx-UP社区参与的研究， 与四个社区合作伙伴共同制定新的招聘战略，以扩大检测范围，包括 让宗教领袖和少数民族医疗保健提供者参与进来，并将我们的移动的检测（和疫苗接种）单位 在教堂停车场。我们还将在完成第一阶段的参与者中进行纵向研究 评估（a）感染和疫苗接种状况的变化，（B）疫苗的可用性如何 影响与检测相关的态度、信念和行为，（c）SDoH的变化及其对COVID-19的影响 测试和疫苗接种/犹豫，以及（d）心理弹性，心理健康， 测试和疫苗摄取/犹豫，以及（e）其他RADx-UP通用数据元素。我们还将进行 关于抗体产生和随后感染的感染后和接种后研究。为 在第二阶段的申请中，我们与新的社区组织合作，包括保持 信仰抗击COVID-19，一个与黑人和黑人合作的少数民族医疗保健提供者组织 西班牙裔教会，并与社区参与联盟（CEAL）反对COVID-19差异 倡议我们目前正在进行RADx-UP第一阶段，建立了基础设施和社区 建立伙伴关系，以实现目标，并在获得和吸收SARS方面产生迅速和可衡量的影响- CoV-2检测服务不足和弱势群体。我们的社区合作伙伴拥有资源， 提供社区参与、公共卫生缓解和对检测呈阳性的病例的后续护理。我们 战略包括科学和社区咨询委员会;一个移动的测试单位;一个CLIA许可的实验室 由本申请的PI领导;数据挖掘和数据分析的纵向方法;以及 研究团队在招募和留住本提案所针对的社区成员方面经验丰富。

PROJECT SUMMARY The COVID-19 pandemic has caused unprecedented public health and economic consequences globally and in the United States. Long-standing social inequities have been magnified and vulnerable communities have been disproportionately burdened by the pandemic. In Miami-Dade County, Florida, where minority populations experience a high level of social vulnerability, Blacks and Hispanics are overrepresented in COVID-19 related hospitalizations and deaths compared to national rates. Further, Miami-Dade County continues to experience COVID-19 rates well above the state and national levels. Effective vaccines are now available, yet vaccination rates have been persistently lower among U.S. minorities, broadening disparities in COVID-19 outcomes. As such, expanded SARS-CoV-2 testing and vaccine acceptance is critical to mitigating community spread in underserved and vulnerable communities. In this application for Phase II of the RADx-UP project, we will apply the knowledge gained during Phase I to expand community outreach to increase testing and vaccine uptake in minority communities to decrease disparities that contribute to burden of COVID-19 in underserved and vulnerable populations. We propose to continue our RADx-UP community-engaged research by employing new recruitment strategies in conjunction with four community partners to increase reach of testing that include engaging faith leaders and minority health care providers, and placing our mobile testing (and vaccination) unit in church parking areas. We will also conduct a longitudinal study among participants who completed Phase I of the study to assess (a) changes in infection and vaccination status, (b) how the availability of vaccines affects attitudes, beliefs, and behaviors related to testing, (c) changes in SDoH and their impact on COVID-19 testing and vaccine uptake/hesitancy, and (d) the relationship between mental resilience, mental health, and testing and vaccine uptake/hesitancy, and (e) other RADx-UP common data elements. We will also conduct post-infection and post-vaccination studies on antibody production and subsequent infections. For the proposed Phase II application, we have partnered with new community organizations, including Keeping the Faith to Fight COVID-19, an organization of minority health care providers working with Black and Black Hispanic churches, and with the Community Engagement Alliance (CEAL) Against COVID-19 Disparities initiative. We are currently conducting RADx-UP Phase I with established infrastructure and community partnerships to accomplish the aims and enable rapid and measurable impact in access and uptake of SARS- CoV-2 testing by underserved and vulnerable populations. Our community partners have the resources to provide community engagement, public health mitigation, and follow-up care for cases who test positive. Our strategy includes Scientific and Community Advisory Boards; a mobile testing unit; a CLIA-licensed laboratory headed by the PI of this application; data mining and longitudinal approaches for data analyses; and a research team experienced in recruiting and retaining members of the communities targeted in this proposal.