Community-Engaged Research on COVID-19 Testing Among Underserved and/or Vulnerable Populations

社区参与的针对服务不足和/或弱势群体的 COVID-19 检测研究

• 批准号: 10662839
• 负责人: Marianna K Baum
• 金额: $ 99.13万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10662839
• 关键词: Adult; African American population; Alcohols; Animal Experiments; Animals; Area; Behavioral; Biological Markers; Biological Specimen Banks; Biological Specimen database; COVID-19 testing; Cause of Death; Cessation of life; Cirrhosis; Clinical; Cocaine; Cocaine Abuse; Cocaine Users; Data; Databases; Diagnostic Equipment; Disease; Disease Outcome; Drug abuse; Etiology; FDA approved; Florida; Funding; Future; Genetic Markers; Goals; HIV; HIV Infections; HIV/HCV; Health; Health Services Accessibility; Hepatitis C; Hepatitis C Therapy; Hepatitis C co-infection; Hepatitis C virus; Heterosexuals; Hispanic; Hispanic Populations; Human; Immunity; Immunosuppression; In Vitro; Intervention; Laboratories; Liver Fibrosis; Liver diseases; Magnetic Resonance Elastography; Malnutrition; Metabolic; Morbidity - disease rate; Nature; Outcome; Oxidative Stress; Participant; Pathogenesis; Pattern; Persons; Pharmaceutical Preparations; Pharmacotherapy; Population; Populations at Risk; Primary carcinoma of the liver cells; Prognostic Factor; Program Development; Program Evaluation; Quality of life; Recording of previous events; Research; Research Design; Resources; Risk Factors; Role; Signal Transduction; Stimulus; Substance abuse problem; Treatment Failure; Underserved Population; United States; United States National Institutes of Health; Virus Diseases; Vulnerable Populations; Woman; antifibrotic treatment; antiretroviral therapy; chronic liver disease; co-infection; cocaine use; cohort; community engaged research; comorbidity; cytokine; data harmonization; drug of abuse; effective intervention; effective therapy; evidence base; fibrogenesis; follow-up; health care availability; health disparity; health disparity populations; improved; insight; interest; liver development; mortality; noninvasive diagnosis; novel; prevent; programs; prospective; recruit; retention rate; sociodemographics; time interval; transmission process; treatment effect; uptake

ABSTRACT Liver disease is a major cause of death in HIV infected persons in the United States. While advances in antiretroviral therapy have significantly reduced HIV-related mortality, co-infection with hepatitis C virus (HCV), is widespread and accelerates progression of liver fibrosis to cirrhosis and liver carcinoma. In addition, substance abuse accelerates HIV disease, and may facilitate progression of liver fibrosis. The primary goal of this proposal is to continue to follow the existing Miami Adult Studies on HIV (MASH) cohort, its specimen repository and database, and expand it from the current 881 to 1,500 study participants. The purpose is to generate collaborative studies to investigate the impact of cocaine, by far the most prevalent drug of abuse in South Florida, on HIV infection, HIV/HCV co-infection, and on long-term morbidity with a focus on liver disease in this population with disparities in access to care. HIV and HCV un-infected cocaine users and non-users will also be recruited to allow determination of the impact of cocaine use alone, as well as the interaction of cocaine use with HIV, HCV, and HIV/HCV co-infection. As new and more effective treatments and access to care for HIV, HCV and drug abuse become available, maintaining a well- characterized cohort, specimen repository and database will create a strong resource platform for current and future collaborative research. Observing the uptake of new HCV treatments and potential new cocaine cessation programs in this at-risk population with health disparities will provide data on barriers and facilitators to effective treatments to prevent long-term morbidity and mortality. We have followed the MASH cohort of 881 participants for up to 12 years with excellent retention rates, and have created a specimen repository and a database. The MASH cohort in Miami is unique because it will be a mostly Hispanic cohort with a large number of African Americans, women, non-injector drug users, with predominantly heterosexual HIV- transmission etiology. We propose to (1) compare the progression of liver fibrosis over four years among cocaine users and non-users in HIV+/HCV-, HIV+/HCV+, HIV-/HCV+, and HIV-/HCV-, using a novel non- invasive diagnostic device, the Magnetic Resonance Elastography (MRE). We also propose to (2) compare the pattern over four years of biomarkers and identify genetic markers associated with the mechanisms of liver fibrosis among cocaine users and non-users. Understanding the role of cocaine use in the context of HIV and HIV/HCV co-infections and lack of lasting effects of treatments for cocaine use cessation are crucial in order to gain insights into the pathogenesis and disease outcomes, and to provide the basis for identifying antifibrotic therapies such as oxidative stress, which are amenable to intervention. These studies will be critical for program development, appropriate interventions, and for improving health in this population.

摘要 肝病是美国HIV感染者死亡的主要原因。虽然在这方面取得了进展， 抗逆转录病毒治疗显著降低了艾滋病毒相关死亡率， (HCV)广泛存在并加速肝纤维化向肝硬化和肝癌的进展。在 此外，药物滥用加速HIV疾病，并可能促进肝纤维化的进展。的 该提案的主要目标是继续跟踪现有的迈阿密成人艾滋病毒研究（MASH）队列， 该研究所将扩大其标本储存库和数据库，并将其研究参与者从目前的881人扩大到1 500人。的 目的是产生合作研究，调查可卡因的影响，迄今为止最普遍的 药物滥用在南佛罗里达，对艾滋病毒感染，艾滋病毒/丙型肝炎病毒合并感染，并对长期发病率与 重点关注这一人群中的肝脏疾病，这些人群在获得护理方面存在差异。未感染HIV和HCV的可卡因 还将招募使用者和非使用者，以便确定单独使用可卡因的影响， 可卡因使用与HIV、HCV和HIV/HCV合并感染的相互作用。新的更为有效的 艾滋病毒、丙型肝炎病毒和药物滥用的治疗和护理变得可用， 特征化的队列、标本库和数据库将为当前的研究建立一个强大的资源平台。 未来的合作研究。观察新的HCV治疗和潜在的新可卡因的吸收 在这种存在健康差异的高危人群中实施戒烟计划，将提供有关障碍和促进因素的数据 有效的治疗，以防止长期发病率和死亡率。我们跟踪了881名MASH队列 参与者长达12年，具有出色的保留率，并创建了一个标本库和一个 数据库迈阿密的MASH队列是独一无二的，因为它将是一个大规模的西班牙裔队列， 非裔美国人、妇女、非注射毒品使用者、主要是异性恋艾滋病毒感染者的人数， 传播病因学我们建议（1）比较四年内肝纤维化的进展， 可卡因使用者和非使用者的HIV+/HCV-、HIV+/HCV+、HIV-/HCV+和HIV-/HCV-，使用一种新的非 侵入性诊断设备，磁共振弹性成像（MRE）。我们还建议（2）比较 模式超过四年的生物标志物，并确定与肝脏机制相关的遗传标记物 可卡因使用者和非使用者之间的纤维化。了解可卡因使用在艾滋病毒和艾滋病方面的作用 艾滋病毒/丙型肝炎病毒合并感染和可卡因戒毒治疗缺乏持久效果至关重要， 深入了解发病机制和疾病结局，并为确定抗纤维化药物提供基础。 治疗，如氧化应激，这是服从干预。这些研究将是至关重要的 制定计划，采取适当的干预措施，改善这一人群的健康状况。

项目成果

Bidirectional associations between e-cigarette use and alcohol use across adolescence.

• DOI: 10.1016/j.drugalcdep.2020.108496
• 发表时间: 2021-03-01
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Lozano A;Liu F;Lee TK;Prado G;Schwartz SJ;Leventhal AM;Kelleghan AR;Unger JB;Barrington-Trimis JL
• 通讯作者: Barrington-Trimis JL

Cocaine use associated gut permeability and microbial translocation in people living with HIV in the Miami Adult Study on HIV (MASH) cohort.

• DOI: 10.1371/journal.pone.0275675
• 发表时间: 2022
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Hernandez, Jacqueline;Tamargo, Javier A.;Martinez, Sabrina Sales;Martin, Haley R.;Campa, Adriana;Sekaly, Rafick-Pierre;Bordi, Rebeka;Sherman, Kenneth E.;Rouster, Susan D.;Meeds, Heidi L.;Khalsa, Jag H.;Mandler, Raul N.;Lai, Shenghan;Baum, Marianna K.
• 通讯作者: Baum, Marianna K.

Polysubstance use and adherence to antiretroviral treatment in the Miami Adult Studies on HIV (MASH) cohort.

• DOI: 10.1080/09540121.2021.1896660
• 发表时间: 2022-05
• 期刊: AIDS care
• 影响因子: 1.7
• 作者: Degarege A;Krupp K;Tamargo J;Martinez SS;Campa A;Baum M
• 通讯作者: Baum M

Effectiveness of a 6-Month Nutrition Intervention in People Living with HIV and Prediabetes Progressing through Stages of Change towards Positive Health Behavior.

• DOI: 10.3390/ijerph192214675
• 发表时间: 2022-11-08
• 期刊: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
• 作者: Sneij, Alicia;Campa, Adriana;Huffman, Fatma;George, Florence;Trepka, Mary Jo;Martinez, Sabrina Sales;Baum, Marianna
• 通讯作者: Baum, Marianna

PNPLA3 Single Nucleotide Polymorphism Prevalence and Association with Liver Disease in a Diverse Cohort of Persons Living with HIV.

• DOI: 10.3390/biology10030242
• 发表时间: 2021-03-21
• 期刊: Biology
• 影响因子: 4.2
• 作者: Sherman KE;Rouster SD;Meeds H;Tamargo J;Chen J;Ehman R;Baum M
• 通讯作者: Baum M