Novel reactive sorbents to sorb, immobilize, and transform malodorous molecules for palliative management of malignant fungating wounds

新型反应性吸附剂可吸附、固定和转化恶臭分子，用于恶性真菌伤口的姑息治疗

• 批准号: 10544741
• 负责人: YUYU SUN
• 金额: $ 19.11万
• 依托单位: UNIVERSITY OF MASSACHUSETTS LOWELL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-30 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10544741
• 关键词: Acids; Acne; Activated Charcoal; Advanced Malignant Neoplasm; Aerobic Bacteria; Affect; Aldehydes; Alginates; Amines; Anaerobic Bacteria; Anxiety; Benzoyl Peroxide; Biopolymers; Cadaverine; Cancer Patient; Carboxylic Acids; Caring; Charcoal; Chitosan; Distress; Environment; Equilibrium; Evaluation; Felis catus; Future; Gagging; General Practices; Goals; Green tea; Honey; Human; Imines; Immobilization; In Vitro; Iodine; Knowledge; Life Expectancy; Loneliness; Malignant - descriptor; Managed Care; Masks; Mental Depression; Methods; Metronidazole; Microbial Biofilms; Odors; Outcome; Palliative Care; Patient Care; Patients; Performance; Persons; Pilot Projects; Polyamines; Polymers; Population; Porosity; Putrescine; Quality of life; Reaction; Reporting; Salts; Side; Silver; Site; Social isolation; Sterile coverings; Structure; Sulfides; Sulfoxide; Sulfur Compounds; Symptoms; Technology; Temperature; Topical application; United States; Volatile Oils; Volatilization; Vomiting; Withdrawal; Work; Wound models; absorption; appetite loss; base; biomaterial compatibility; chemical reaction; chronic wound; covalent bond; design; disabling symptom; end of life; healing; improved; in vitro Model; new technology; novel; novel strategies; organic acid; palliative; preference; psychologic; psychological distress; social; success; sugar; symptom management; wound; wound dressing

Project Summary/Abstract Malignant fungating wounds (MFWs) affect 5% to 14% of advanced cancer patients in the United States. Sadly, the average life expectancy for a person living with MFWs is six to twelve months. Malodor is the most distressing and debilitating symptom of MFWs, causing gagging, vomiting, loss of appetite, and psychological distress, including social withdrawal, social isolation, anxiety, loneliness, and depression. Malodor results from a cocktail of volatile agents that includes acids, polyamines, and sulfur compounds such as dimethyl trisulfide (DMTS). The current methods used to manage malodor are: (a) reducing bioburdens that cause odor, (b) masking the odor, and (c) absorbing the odor (e.g., via charcoal, green tea teabags, cat litter, etc.). However, these strategies offer only limited success and malodor continues to be the worst aspect of MFWs. The goals of advanced cancer patient care should include a palliative approach for symptom management to improve quality of life. To this end, this project will develop a novel reactive sorbent approach to sorb, immobilize, and/or transform malodorous molecules that are generated by MFWs to improve odor management in palliative care. This new strategy has never been reported before. We will selectively oxidize alginate (a natural anionic polymer) to generate covalently bonded aldehyde groups for charcoal coating to form porous amine-reactive sorbents. In this design, the charcoal will sorb polyamines (e.g., putrescine and cadaverine) to reduce their contents, the carboxylic acid groups on the alginate will ionically immobilize the amines through acid/base reactions, and the aldehyde groups will covalently immobilize the amines through the formation of odorless imine structures. Also, we will use chitosan, a natural cationic polymer, to coat benzoyl peroxide (BPO), a mild oxidizer for acne treatment, onto charcoal to form porous acid-/DMTS-reactive sorbents. The charcoal will sorb the acids (e.g., n-butyric, n-valeric, and n-caproic) and DMTS, the chitosan will react with the acids to form odorless salts through acid/base reaction, and the BPO will oxidize the DMTS to transform it into sulfoxide and thiosulfinate derivatives with a much less unpleasant odor. These combined actions are expected to improve the level of odor management significantly. The specific aims of this project are to: (1) fabricate new reactive sorbents, (2) evaluate in vitro the odor control performance of the new reactive sorbents, and (3) evaluate the performance of the new reactive sorbents in a wound-like in vitro model. A unique feature of the reactive sorbents is that they will not only sorb malodorous molecules to reduce the molecule content, but they also will react with the molecules to transform them into non-volatile, odorless (or with a much less unpleasant odor) molecules. The reactive sorbents can be used alone or with current odor-managing strategies for comprehensive odor management. Thus, this work will have a major positive impact on the palliative care of end-of-life cancer patients.

项目摘要/摘要 在美国，恶性结合伤口（MFW）影响了5％至14％的晚期癌症患者。 可悲的是，患有MFWS的人的平均预期寿命为六到十二个月。马多是最大的 MFW的痛苦和使人衰弱的症状，导致作用，呕吐，食欲不振和心理 困扰，包括社会戒断，社会隔离，焦虑，孤独和沮丧。 MALODOR的结果 挥发性剂的鸡尾酒，包括酸，多胺和硫化合物，例如三甲基三硫化物 （DMTS）。用于管理肺炎的当前方法是：（a）减少引起气味的生物毛发，（b） 掩盖气味，（c）吸收气味（例如，通过木炭，绿茶袋，猫垃圾等）。然而， 这些策略仅提供有限的成功，而Malodor仍然是MFW中最糟糕的方面。 晚期癌症患者护理的目标应包括症状管理的姑息治疗方法 改善生活质量。为此，该项目将开发出一种新型的反应性吸附方法，以使SORB， 固定和/或转化由MFWS产生以改善气味的恶臭分子 姑息治疗的管理。这种新策略以前从未报道过。我们将有选择地氧化 藻酸盐（一种天然的阴离子聚合物），以生成共价键合的醛类，用于木炭涂层 形成多孔胺反应吸附剂。在此设计中，木炭将Sorb多胺（例如，prescine和 尸体）为了减少其含量，藻酸盐上的羧酸基将在离子上固定 通过酸/碱反应的胺，醛组将通过 无味亚胺结构的形成。另外，我们将使用天然阳离子聚合物壳聚糖涂层 苯甲酰过氧化物（BPO），一种用于痤疮处理的温和氧化剂，可在木炭上形成多孔酸 - /DMTS反应性 吸附剂。木炭将吸收酸（例如，n-丁基，n个字体和n-coproic）和dmts，壳聚糖 将与酸反应通过酸/碱反应形成无味盐，而BPO将氧化DMTS 将其转化为硫氧化硫化和硫代硫化衍生物，具有不愉快的气味。这些结合了 预计行动将大大提高气味管理水平。 该项目的具体目的是：（1）制造新的反应性吸附剂，（2）在体外评估气味 控制新的反应吸附剂的性能，以及（3）评估新反应性的性能 类似伤口的体外模型中的吸附剂。反应性吸附剂的独特特征是它们不仅会索布 降低分子以减少分子含量，但它们也会与分子反应以转化 它们变成非挥发性，无味的（或不愉快的气味）分子。反应性吸附剂可以是 单独使用或与当前的气味管理策略一起用于全面的气味管理。因此，这项工作将 对临终癌症患者的姑息治疗有重大积极影响。