Trajectories of ovarian reserve and cardiovascular risk in Black and White women

黑人和白人女性卵巢储备和心血管风险的轨迹

• 批准号: 10559092
• 负责人: Elaine Mott Urbina
• 金额: $ 20.5万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10559092
• 关键词: Administrative Supplement; Affect; Age; Appearance; Applications Grants; Black race; Cardiac; Cardiovascular Diseases; Cardiovascular system; Cohort Studies; Data; Data Collection; Development; Disease; Echocardiography; Enrollment; Evaluation; Future; Growth; Growth and Development function; Health; Heart failure; Hormones; Image; Laboratories; Lead; Life; Life Cycle Stages; Link; Lipoproteins; Longevity; Longitudinal cohort; Longterm Follow-up; Menopause; National Heart, Lung, and Blood Institute; Ovarian; Ovarian Follicle; Ovarian aging; Ovarian hormone; Parents; Participant; Particle Size; Pattern; Play; Pregnancy; Premenopause; Process; Production; Questionnaires; Race; Reproductive History; Reproductive system; Research; Research Personnel; Risk; Role; Sampling; Sampling Studies; Serum; Socioeconomic Status; Structure; Testing; Time; Update; Woman; black women; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; cohort; critical period; design; diminished ovarian reserve; early onset; girls; healthy aging; improved; insight; mortality; mullerian-inhibiting hormone; novel; ovarian reserve; parent grant; parity; prospective; racial difference; racial diversity; racial population; recruit; reproductive; satisfaction; social health determinants

Abstract The reproductive lifecycle of a women can affect her long-term health including onset of cardiovascular disease. The menopausal transition affects the onset and timing of cardiovascular changes that can lead to long term health consequences. There is a link between the age at menopause and cardiovascular mortality and heart failure, as earlier onset of menopause is associated with higher rates of cardiovascular disease. The size of the ovarian follicle pool and cessation of ovarian hormone production is a key factor that influences the timing of menopause. Serum anti-mullerian hormone (AMH) has emerged as an important marker of the ovarian follicle pool. AMH has been shown to reflect the gradual decline in reproductive capacity with increasing age. Early decline in AMH and a more rapid trajectory of decline have been associated with increased risk for cardiovascular disease. This study supplement will test AMH values at multiple timepoints over the reproductive lifespan by utilizing stored samples and prospective samples from the NHLBI Growth and Health Study (NGHS). NGHS enrolled 871 girls (50% Black and 50% White) in 1987 at age 9 or 10 and examined them up to 17 times, to age 27, including 7 echocardiograms between ages 20-27, multiple saved samples and reproductive history questionnaires. The parent study for this supplement will be enrolling 350 NGHS participants in the late reproductive stage (average age 46) and collecting cardiovascular labs and imaging as well as update lifetime information on socioeconomic status and social determinants of health. This supplement will add assessment of ovarian reserve trajectory of time to: 1) Determine differences in the ovarian reserve and its trajectories between Black and White women and how the social determinants of health (SDOH) impact this difference; 2) Determine if the trajectory of ovarian reserve decline across the reproductive life-course affects cardiovascular disease risk or disease. In addition, this supplement aims to create a study participant advisory group to help optimize study recruitment and retention particularly in Black women. With completion of our aims, we will understand the effect of SDOH and race on ovarian reserve as well as determine if the rate of ovarian reserve decline can be a marker for future cardiovascular disease. This supplement is designed to enhance the parent grant by adding additional information about the reproductive system affecting cardiovascular disease as well as provide mechanisms to improve subject recruitment, retention, and satisfaction with the study.

摘要 女性的生殖周期会影响其长期健康，包括 心血管疾病绝经过渡期会影响 心血管变化可能导致长期的健康后果。有个环节 绝经年龄与心血管死亡率和心力衰竭之间的关系， 绝经期妇女患心血管疾病的几率更高。卵巢的大小 卵泡池和卵巢激素分泌的停止是影响 更年期的时间血清抗苗勒管激素（AMH）已成为一个重要的 卵巢卵泡池的标志物。AMH已被证明反映了 随着年龄的增长，生育能力。AMH的早期下降和AMH的更快轨迹 下降与心血管疾病风险增加有关。本研究 补充将测试AMH值在多个时间点在生殖寿命，利用 NHLBI生长和健康研究（NGHS）的储存样本和预期样本。 1987年，NGHS招募了871名9岁或10岁的女孩（50%黑人和50%白色）， 他们最多17次，年龄到27岁，包括7次20-27岁之间的超声心动图，多次 保存的样本和生殖史问卷。本补充的母研究 将招募350名生殖后期（平均年龄46岁）的NGHS参与者， 收集心血管实验室和成像以及更新生命周期信息 社会经济地位和健康的社会决定因素。此补充将增加评估 卵巢储备的时间轨迹：1）确定卵巢储备及其 黑人和白色妇女之间的轨迹以及健康的社会决定因素（SDOH） 影响这种差异; 2）确定卵巢储备下降的轨迹是否在整个 生殖生命过程影响心血管疾病风险或疾病。另外这款 增补旨在创建研究参与者咨询小组，以帮助优化研究招募 尤其是黑人女性。随着我们目标的完成，我们将了解 SDOH和种族对卵巢储备功能的影响，以及确定卵巢储备率是否 下降可能是未来心血管疾病的标志。该补充旨在 增加关于生殖系统的额外信息，以增加父母补助金; 影响心血管疾病以及提供改善受试者招募的机制， 保持和对研究的满意度。