CV RISK FACTORS/VASCULAR FUNCTION

心血管风险因素/血管功能

• 批准号: 7607793
• 负责人: Elaine Mott Urbina
• 金额: $ 2.51万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607793
• 关键词: Adult; Autopsy; Blood Pressure; Blood Vessels; Calcium; Cardiac; Carotid Arteries; Case-Control Studies; Cephalic; Child; Childhood; Computer Retrieval of Information on Scientific Projects Database; Condition; Data; Databases; Dental; Diabetes Mellitus; Disease; Dyslipidemias; Early Intervention; Event; Family history of; Fasting; Fibrinogen; Functional disorder; Funding; Future; Generalized Atherosclerosis; Glucose; Grant; Head; High Prevalence; Homocysteine; Homocystine; Individual; Inflammation; Institution; Insulin; Laboratories; Leg; Lesion; Lipids; Medial; Outcome; Pediatric Radiologist; Peripheral; Phosphorus; Physiologic pulse; Pulse taking; Research; Research Personnel; Resources; Risk; Risk Factors; Roentgen Rays; Scanning; Site; Source; Stenosis; Stroke; Temporal bone structure; Testing; Thick; Ultrasonography; United States National Institutes of Health; Upper arm; Vascular calcification; X-Ray Computed Tomography; brachial artery; calcification; calcium phosphate; case control; cysteine rich protein; demographics; indexing; prevent; radiologist; theories

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Calcifications of the intra-cranial carotid arteries (ICA) are frequently found in adults on routine head CT scans. They correlate strongly with CV risk factors & are associated with angiographic vessel stenosis supporting the idea that vascular calcifications are a marker for generalized atherosclerosis. Even simple dental X-rays may identify calcifications which relate to abnormal carotid ultrasound & predict subsequent vascular events. The significance of ICA calcifications in children is not known eve though radiologist frequently recognize them on head CT scans and one small pediatric autopsy study found a high prevalence of such lesions. These data led us to hypothesize that ICA calcifications in children represent early atherosclerotic change. We will test this theory by performing a case-control study selecting subjects from an existing database of children who underwent a temporal bone CT scan. These scans collected over 2 years, were evaluated by Pediatric Radiologist for presence of ICA calcification. Of 408 children, 27% had calcification although only 1 had a medial condition that might explain the findings (diabetes and dyslipidemia). Fifty cases & fifty controls will be studies with 1/2 of the subject younger (6 to 12 years) and 1/2 older (12 to 19 years) for a total of 100. Demographics, medical and family history, anthropometrics & blood pressure data will be collected. Laboratory analyses will include calcium, phosphorus, glucose & insulin levels, fasting lipid panel, high sensitivity CRP, homocysteine & fibrinogen. Central & peripheral vascular sites tested will include carotid intimate-media thickness & compliance, aortic augmentations index, brachial artery distensibility & pulse wave velocity to the arm, trunk & leg. Analyses will be performed to determine if children with ICA calcification 1) demonstrate other abnormalities in vascular function; 2) have abnormal levels of CV risk factors; and 3) whether vascular abnormalities correlate with levels of CV risk factors. Potential mechanisms underlying early vascular calcifications and dysfunction will also be explored by comparing calcium-phosphate product, levels of systemic inflammation, fibrinogen and homocysteine between cases & controls. The proposed research will allow us to determine the importance of vascular calcification as a marker for early atherosclerotic disease in children allowing earlier intervention in high risk individuals to prevent future adverse cardiac and stroke-related outcomes.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 颅内颈动脉（ICA）的钙化经常在常规头部CT扫描中进行。 它们与简历危险因素密切相关，并且与血管造影血管狭窄相关，该狭窄支持血管钙化是广泛性动脉粥样硬化的标志的想法。 即使是简单的牙科X射线，也可以识别与异常颈动脉超声和预测随后的血管事件有关的钙化。 尽管放射科医生经常在头部CT扫描中识别出它们，但尚不清楚儿童钙化的意义，而一项小的儿科尸检研究发现这种病变的患病率很高。 这些数据导致我们假设儿童的ICA钙化代表了早期的动脉粥样硬化变化。 我们将通过进行病例对照研究来测试该理论，该研究从接受颞骨CT扫描的儿童数据库中选择受试者。 这些在2年内收集的扫描通过小儿放射科医生评估了ICA钙化。 在408名儿童中，有27％的儿童患有钙化，尽管只有1个患有内侧疾病，可以解释发现（糖尿病和血脂异常）。 五十例和五十个对照将是对年龄较小（6至12岁）和1/2岁（12至19岁）的1/2的研究，总共有100个。人口统计学，医学和家族史，人类学和血压数据将被收集。 实验室分析将包括钙，磷，葡萄糖和胰岛素水平，禁食脂质面板，高灵敏度CRP，同型半胱氨酸和纤维蛋白原。 所测试的中央和周围血管部位将包括颈动脉亲密媒体厚度和合规性，主动脉增强指数，臂动脉膨胀性和脉冲波速度对手臂，躯干和腿部。 将进行分析以确定ICA钙化儿童是否表明血管功能其他异常； 2）具有异常的简历危险因素； 3）血管异常是否与简历危险因素水平相关。 还将通过比较磷酸钙产物，系统炎症水平，纤维蛋白原和同型半胱氨酸之间的早期血管钙化和功能障碍的潜在机制。 拟议的研究将使我们能够确定血管钙化为早期动脉粥样硬化疾病的标志性的重要性，从而使早期干预高风险个体以防止未来的不良心脏和中风相关结果。