MECHANISMS OF VASCULAR DYSFUNCTION IN OBESITY

肥胖引起的血管功能障碍的机制

• 批准号: 7607799
• 负责人: Elaine Mott Urbina
• 金额: $ 1.23万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607799
• 关键词: Adipose tissue; Adolescent; Adult; Blood Vessels; Child; Childhood; Computer Retrieval of Information on Scientific Projects Database; Coronary Arteriosclerosis; Cross-Sectional Studies; Diabetes Mellitus; Dilatation - action; Dyslipidemias; Early treatment; Functional disorder; Funding; Future; Grant; Heart Diseases; Hyperinsulinism; Inflammation; Institution; Insulin; Insulin Resistance; Laboratories; Lead; Lipids; Measurement; Measures; Mediating; Metabolic; Metabolic syndrome; Myocardial Infarction; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Organ; Overweight; Pathological Dilatation; Pathway interactions; Physiologic pulse; Pulse taking; Research; Research Personnel; Resources; Risk; Risk Factors; Sampling; School-Age Population; Schools; Source; Stroke; United States National Institutes of Health; adiponectin; brachial artery; cohort; cysteine rich protein; cytokine; indexing; prevent; protective effect

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Childhood obesity has increased dramatically in the U.S. in the last decade. Unfortunately, these overweight children are at risk for target organ damage, adult diabetes, heart disease and stroke. One of the pathways by which obesity may induce target organ damage involves adiponectin (APN) an adipose-tissue derived cytokine. APN has direct vascular protective effects. However, it is found in reduced levels in obesity, obesity related inflammation and in coronary artery disease. Low levels are associated with insulin resistance and the dyslipidemia found as part of the metabolic syndrome. Therefore, we propose a cross-sectional study of school aged adolescents to study relationships between obesity and vascular function. Analyses will be performed to determine if the mechanisms underlying arterial dysfunction may relate to abnormal levels of CV risk factors, inflammation and APN. Brachial Artery Distensibility, BMI, BP, lipids, high sensitivity CRP, and APN will be measured in the ongoing 'Landmarks in the Progression to Type 2 Diabetes' study currently being conducted in the Princeton School District (N=2000). A sample of this cohort (n=450) will also undergo brachial flow mediated dilatation, measurement of augmentation index & pulse wave velocity. Contrasts in laboratory and vascular measures will be made among normals, obese subjects with normal insulin levels and obese adolescents with hyperinsulinemia. Showing that metabolic abnormalities related to overweight lead to blood vessel dysfunction in children will help doctors identify high risk children for early treatment to prevent future heart attack and stroke.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 过去十年，美国儿童肥胖症急剧增加。 不幸的是，这些超重的儿童面临靶器官损伤、成人糖尿病、心脏病和中风的风险。 肥胖可能引起靶器官损伤的途径之一涉及脂联素（APN），一种脂肪组织衍生的细胞因子。 APN具有直接的血管保护作用。 然而，它在肥胖、肥胖相关炎症和冠状动脉疾病中的水平降低。 低水平与胰岛素抵抗和代谢综合征中发现的血脂异常有关。 因此，我们建议对学龄青少年进行一项横断面研究，以研究肥胖与血管功能之间的关系。 将进行分析以确定动脉功能障碍的机制是否可能与心血管危险因素、炎症和 APN 的异常水平有关。 目前正在普林斯顿学区进行的“2 型糖尿病进展的标志”研究（N=2000）将测量肱动脉扩张性、BMI、血压、血脂、高敏 CRP 和 APN。 该队列的样本 (n=450) 还将接受肱动脉血流介导的扩张、增强指数和脉搏波速度的测量。 将在正常人、胰岛素水平正常的肥胖受试者和患有高胰岛素血症的肥胖青少年之间进行实验室和血管测量的对比。 表明与超重相关的代谢异常会导致儿童血管功能障碍，这将有助于医生识别高危儿童并进行早期治疗，以预防未来心脏病和中风的发生。