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Violence Across the Lifespan - Opioids Maternal Brain

一生中的暴力 - 阿片类药物母脑

基本信息

批准号：
10558931
负责人：
James Edward Swain
金额：
$ 22.33万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-30 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10558931
关键词：
Adaptive Behaviors Administrative Supplement Adult Adverse effects Affect Aggressive behavior Alcohol consumption Amygdaloid structure Area Attention Back Base of the Brain Behavior Behavioral Behavioral Mechanisms Brain Buprenorphine Caring Categories Child Child Abuse and Neglect Child Rearing Chronic Code Data Depression and Suicide Discrimination Disease Drug usage Emotional Empathy Epidemic Equilibrium Face Family Functional Magnetic Resonance Imaging Globus Pallidus Gold Grant Health Household Human Hypothalamic structure Image Impairment Incidence Income Infant Infant Development Interpersonal Relations Interpersonal Violence Intervention Studies Jealousy Knowledge Link Literature Longevity Maternal Behavior Measurement Measures Medial Mediating Mediation Mental Depression Modeling Mothers Motor National Institute of Drug Abuse Neonatal Abstinence Syndrome Nucleus Accumbens Opioid Opioid replacement therapy Outcome Output Parents Participant Perinatal Physiology Population Postpartum Period Pregnancy Pregnant Women Preoptic Areas Psychopathology Public Health Publications Publishing Questionnaires Recording of previous events Relapse Research Resolution Rest Risk Shapes Skin Social Policies Socioeconomic Status Stress Suicide attempt Testing Thinking Trauma Ursidae Family Ventral Tegmental Area Violence Withdrawal Withdrawal Symptom Woman Women&apos s Health abuse neglect adverse childhood events brain behavior buprenorphine treatment clinical decision-making comorbid depression comparison group cost deprivation disorder control dyadic interaction early life adversity flexibility foster care functional MRI scan gray matter health disparity high risk illicit opioid indexing infant outcome intimate partner violence maltreatment maternal caregiving midbrain central gray substance multimodality next generation non-opioid analgesic opioid epidemic opioid mortality opioid use opioid use disorder pediatric trauma polysubstance use relating to nervous system resilience response social social cognition social inequality social vulnerability sociodemographics translational potential violence exposure virtual

项目摘要

Project Summary/ Abstract Violence Across the Lifespan – Opioids Maternal Brain Peripartum women affected by the fast-growing and devastating epidemic of Opioid use disorder (OUD) in the US constitute an understudied, underrepresented, and underreported (U3) population of significant public health importance. OUD, which is associated with violence across the lifespan, manifests withdrawal symptoms, impaired interpersonal interactions, depression, neonatal abstinence syndrome and higher risks of child maltreatment. We plan to piggy-back this administrative supplement on our current NIDA R01 DA047336 “Opioids and Maternal Brain-Behavior Adaptation During the Early Postpartum”, which is examining mechanisms in our corticolimbic maternal behavior neurocircuit (MBN) that regulate parenting behaviors and may be affected by OUD. The MBN contains brain circuits, that are also established to be affected childhood trauma and interpersonal violence. For maternal behavior, there are two reciprocally inhibiting subsystems for (1) care, mediated by the medial preoptic area in the hypothalamus, ventral tegmental area, nucleus accumbens and ventral pallidum; and (2) defense/aggression, mediated by periaqueductal grey. The MBN regulates flexible responses to the demands of mother's own infant during the early postpartum period – such as to the unique, ethologically salient own-baby cry and empathic responses to own infant images. Within the scope of our R01, this Supplement will examine human maternal brain-behavior in the participant mothers undergoing Buprenorphine Treatment (BT) for OUD (n=32) as compared to non-OUD depression Matched Controls (MC, n=32). In the concurrent R01, all participants are already undergoing fMRI scans at ~6 months month postpartum with measures of resting-state functional connectivity, neural responses to own-baby cry, and gray matter volumes of MBN. The supplement will allow us to add a “bonus” Child Face Mirror Task (CFMT) as a neural measure of maternal empathy. We will also add measures of child & recent trauma, interpersonal violence, social inequality, deprivation, discrimination, and resilience. Thus. with this interdisciplinary supplement, in answer to NOT-OD-22-031 “Research on the Health of Women of Understudied, Underrepresented and Underreported (U3) Populations”, we propose specific aims to explore a mediation model that will (1) examine associations between childhood trauma and current interpersonal violence, OUD, and MBN dysregulation and (2) examine brain-behavior mechanisms in maternal social cognition and intersubjectivity, that may be crucial for OUD and infant outcome. We will also explore the scant knowledge and brain behavior mechanisms on the impact of violence across the lifespan on the U3 population of pregnant women – with and without OUD. Translational potentials include better understandings of risk/resilience profiles for mothers with OUD that bear the transgenerational burden of peripartum drug use and may be exposed to violence.

项目总结/摘要生命周期中的暴力-阿片类药物母体大脑受阿片类药物使用障碍（OUD）快速增长和破坏性流行影响的围产期妇女美国构成了一个研究不足，代表性不足，报告不足（U3）人口的重要公众健康的重要性。OUD与整个生命周期的暴力有关，症状，人际交往受损，抑郁症，新生儿戒断综合征和虐待儿童。我们计划将此管理补充文件搭载在我们当前的NIDA R 01 DA 047336上 “阿片类药物和产妇的大脑行为适应在产后早期”，这是研究我们的皮质边缘母性行为神经回路（MBN）中调节养育行为的机制，可能会受到OUD的影响。MBN包含大脑回路，也被确定为受童年影响创伤和人际暴力。对于母性行为，有两个抑制子系统， (1)护理，介导下丘脑内侧视前区，腹侧被盖区，核（2）防御/攻击，由导水管周围灰质介导。MBN 在产后早期，调节对母亲自己的婴儿的需求的灵活反应-例如关于独特的，行为学上显著的自己婴儿的哭声和对自己婴儿形象的移情反应。内我们的R 01范围内，本补充将研究人类母亲的大脑行为在参与者的母亲接受丁丙诺啡治疗（BT）治疗OUD（n=32）与非OUD抑郁症相比对照组（MC，n=32）。在同期的R 01中，所有参与者在约6个月时已经接受了fMRI扫描产后一个月，测量静息状态功能连接，对自己婴儿哭泣的神经反应，和脑灰质体积的变化补充将允许我们添加一个“奖金”儿童脸镜任务（CFMT）作为母性同理心的神经测量。我们还将增加儿童和近期创伤的措施，人际暴力、社会不平等、剥夺、歧视和复原力。因此。与此对NOT-OD-22-031“关于妇女健康的研究”的答复研究不足，代表性不足和报告不足（U3）的人口”，我们提出了具体的目标，探索一个中介模型，将（1）检查童年创伤和当前人际暴力，OUD和MBN失调和（2）检查大脑行为机制，母亲的社会认知和主体间性，这可能是至关重要的OUD和婴儿的结果。我们将还探讨了缺乏知识和大脑行为机制对暴力的影响， U3孕妇人群的寿命-有和没有OUD。翻译潜力包括更好地理解承受跨代负担的OUD母亲的风险/复原力状况，围产期吸毒并可能遭受暴力。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Neurobiology of peripartum mental illness.

DOI：
10.1016/b978-0-12-819973-2.00005-8
发表时间：
2021
期刊：
Handbook of clinical neurology
影响因子：
0
作者：
J. Pawluski;J. Swain;J. Lonstein
通讯作者：
J. Pawluski;J. Swain;J. Lonstein

Intersubjectivity as an antidote to stress: Using dyadic active inference model of intersubjectivity to predict the efficacy of parenting interventions in reducing stress-through the lens of dependent origination in Buddhist Madhyamaka philosophy.

DOI：
10.3389/fpsyg.2022.806755
发表时间：
2022
期刊：
FRONTIERS IN PSYCHOLOGY
影响因子：
3.8
作者：
Ho, S Shaun;Nakamura, Yoshio;Gopang, Meroona;Swain, James E
通讯作者：
Swain, James E

Protocol for a randomized controlled trial comparing the Circle of Security-parenting (COS-P) with treatment as usual in child mental health services.

DOI：
10.1371/journal.pone.0265676
发表时间：
2022
期刊：
PLOS ONE
影响因子：
3.7
作者：
Bikic, Aida;Smith-Nielsen, Johanne;Dalsgaard, Soren;Swain, James;Fonagy, Peter;Leckman, James F.
通讯作者：
Leckman, James F.

Reduced Child-Oriented Face Mirroring Brain Responses in Mothers With Opioid Use Disorder: An Exploratory Study.