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A scalable system for high-throughput and longitudinal electrophysiology in rodent brain research

啮齿动物大脑研究中高通量和纵向电生理学的可扩展系统

基本信息

批准号：
10565321
负责人：
Mattias Peter Karlsson
金额：
$ 16.82万
依托单位：
SPIKEGADGETS, LLC
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10565321
关键词：
Address Administrative Supplement Animal Disease Models Animals Behavior Behavioral Brain Brain region Chronic Code Complex Computers Consumption Custom Data Decision Making Development Disease Disease Progression Disease model Electrodes Electronics Electrophysiology (science)Equipment Functional disorder Goals Head Lead Life Light Measurement Memory Mental disorders Mus Nature Neurons Neurosciences Research Pathologic Pattern Pharmaceutical Preparations Psychiatric therapeutic procedure Research Research Personnel Resolution Resources Rice Rodent Rodent Diseases Rodent Model Social Interaction Stream System Techniques Technology Therapeutic Time TimeLine Tissues Universities austin behavior measurement biomaterial compatibility brain research brain tissue cohort cost design flexibility grasp improved in vivo innovation integrated circuit light weight miniaturize minimally invasive neural circuit neuropsychiatric disorder new therapeutic target pre-clinical therapy relating to nervous system success therapy development tool

项目摘要

Psychiatric disorders give rise to aberrant patterns of activity within the complex neural circuits of our brains. Yet, the exact nature of these abnormal patterns is often unknown to developers of new treatments. The goal of this project is to enable circuit-oriented research of neuropsychiatric diseases using rodent disease models. The long-term objective is to catalyze the discovery of new therapeutic targets for a variety of disorders and to provide a tool to study animal-to-animal variability in neural coding. A new type of research tool will be developed and commercialized that is specialized for high-throughput, detailed, and long-term neural measurements in behaving mice. We will develop of a data logging system that is lightweight enough for a freely-moving mouse to carry as well as flexible electrode technology that is minimally invasive to brain tissue. By enabling high-throughput and long-term recordings, this tool provides a practical way to study the progression of circuit dysfunction using large cohorts of animal disease models.

精神疾病引起复杂神经回路中的异常活动模式我们大脑的一部分。然而，开发人员通常不知道这些异常模式的确切性质新的治疗方法。该项目的目标是使面向电路的研究，使用啮齿动物疾病模型的神经精神疾病。长期目标是促进发现各种疾病的新治疗靶点，并提供一种研究工具，动物间神经编码的差异将开发一种新型的研究工具，商业化，专门用于高通量，详细和长期的神经测量行为小鼠。我们将开发一个轻量级的数据记录系统足以让一个自由移动的鼠标携带，以及灵活的电极技术，对脑组织的创伤最小通过实现高通量和长期记录，该工具提供了一种使用大型队列研究回路功能障碍进展的实用方法动物疾病模型。