权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

RR&D Research Career Scientist Award Application

基本信息

批准号：
10664827
负责人：
Glenn Klute
金额：
--
依托单位：
VA PUGET SOUND HEALTHCARE SYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-10-01 至 2023-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10664827
关键词：
Address Air American Ankle Area Award Biomimetics Bionics Characteristics Classification Clinical Communities Complex Couples Custom Data Data Set Development Devices Distal Elements Environment Equilibrium Etiology Funding Gait Geography Goals Grant Household Incidence Individual Injury Intellectual Property Intervention Intuition Kinetics Knowledge Laboratories Learning Left Life Experience Limb Prosthesis Limb structure Locomotion Lower Extremity Marketing Measures Military Personnel Modeling Motion Motor Muscle Output Participant Pattern Recognition Persons Population Posture Pregnancy Process Property Prosthesis Provider Quality of life Ramp Rehabilitation therapy Research Research Support Risk Robotics Scientist Skin Skin Temperature Skin injury Soft Tissue Injuries Source Surgeon Suspensions System Temperature Testing Thermodynamics Time Torque Torsion Trauma Ulcer Vacuum Veterans Walking Weight Weight Gain Work career clinical decision-making clinical practice clinically relevant cloud based design diabetic efficacy evaluation experience falls foot functional outcomes graduate student graphical user interface improved improved mobility innovation instrument learning algorithm limb amputation limb loss machine learning algorithm new product development new technology next generation novel peer power consumption preference prophylactic prosthesis control prosthesis fitting prosthetic foot randomized, clinical trials rehabilitative care residual limb response restoration skills soft tissue stem tool walking speed wearable device

项目摘要

Project Summary (current research and goals) My research aims to improve the mobility of veterans with lower limb amputation, reduce their risk of injury, and enhance their comfort while wearing a prosthesis. I explore innovative ideas that could dramatically advance the state-of-the-art and use randomized clinical trials to determine the efficacy and efficiency of currently- prescribed interventions to guide clinical decision-making. The exploration of innovative ideas offers the opportunity to dramatically alter functional outcomes through the development of highly imaginative, novel devices. With the help of veterans, graduate students, professional staff, and colleagues, I am currently developing six lower limb prostheses to address the mobility, injury, and comfort problems of veterans with lower limb amputation. To improve mobility, two of these prostheses explore balance improvement while walking on uneven terrain; both have inverting and everting ankles with controllable stiffness and one can conform to terrain undulations like the natural limb. As VA Merit Review support for this research recently ended, I plan a grant submission to extend this work in December 2018. A third mobility- enhancing prosthesis I am developing uses a biologically-inspired actuator and incorporates a learning algorithm that can adapt propulsive outputs to changing needs (the topic of a pending VA Merit Review). Carrying a heavy box or donning a backpack exemplify short duration, sudden onset changes to actuation and propulsive needs, while weight gains associated with pregnancy are an example of slow, but long-lasting changes. I am exploring how machine learning algorithms may enable intuitive prosthesis control in response to these changing conditions. To reduce soft tissue injury risk, the fourth and fifth prostheses I am developing aim to reduce the torsional loads applied the residual limb. One has variable torsional stiffness that can change with walking speed, turning direction, and user preference. The other, inspired by the function of the natural limb, couples sagittal and transverse plane motions and is the topic of a recently funded VA Merit Review. With intellectual property protections in place, this biomimetic prosthesis may offer a high payoff in the commercial market place. Finally, to enhance comfort, the sixth prosthesis I am developing aims to expel perspiration from the socket-suspension system during vigorous activities before discomfort and slippage occur. The work to develop this comfort- enhancing prosthesis was recently selected for DOD funding. Each of these novel devices tackles a clinically- driven problem for which there is currently no solution. A more immediate goal of my research is to provide clinicians with evidence to guide clinical decision-making. A challenging task faced by providers for individuals with lower limb amputation is choosing among the 200+ commercially available prosthetic feet. To help inform their decisions, I am making a graphical user interface tool available to aid with the prescription process. This tool uses experimental data from a robotic gait simulator that measures gait influencing characteristics of prosthetic feet. To explore the efficiency of different rehabilitation interventions, I am collecting activity level data from a geographically-dispersed population with a cloud-based system. With over ninety participants and nearly three years of observations, this rich data set will provide fundamental knowledge. On a subset of this population, I am using a custom-built instrument to classify and count the number of steps taken during different locomotion activities (i.e., walking straight on level ground, up and down stairs, up and down ramps, and turning left and right) to provide perspective on the design requirements of next generation prostheses. I believe the knowledge disseminated from my research will provide evidence to guide both commercial development of new products and current clinical practice. I expect both to lead to substantial quality of life improvements for veterans with lower limb amputation.

项目总结（当前研究和目标）