Mentored Patient-Oriented Research on Adolescent Alcohol Misuse and Treatment

项目摘要/摘要 这项K24职业生涯中期研究和指导计划旨在为应聘者提供保护时间，使其 指导患者护理，对青少年酒精滥用进行以患者为中心的研究(POR)并指导 成瘾科学翻译研究中的早期临床研究人员。迎接……的挑战 为数百万努力减少饮酒的美国年轻人提供治疗选择 该领域需要训练有素的研究人员，他们能够整合各种尖端概念和方法 各区域的。随着我们对成瘾的理解变得更加复杂，早期- 职业科学家。在二十多年的时间里，候选人已经建立了一个富有成效的、持续资助的 POR计划，将理论驱动的假说从临床前和人体实验室研究转化为真实 全球应用。拟议的综合计划将促进候选人指导职业生涯早期的能力 在POR中担任临床研究人员，增强了他作为一名独立临床科学家的能力。这项研究 该计划的重点是通过数字健康改善青少年酒精滥用的治疗选择， 通过为早期职业科学家提供一种指导工具来符合指导目标：i)机制 酒精使用障碍的发病机制和治疗效果，二)临床试验方法，三)生态瞬时 评估方法，以及iv)负责任地开展研究的培训。候选人的目标是 进一步开发和改进实验疗法方法，以产生高质量的信息 决定是否需要进一步开发新的治疗方法。这款K24将支持 基于心理社会金标准的综合数字健康平台试点数据收集 治疗青少年AUD的干预措施。青春期是青春期糖尿病发病的关键时期 澳元。酒精使用通常从青春期开始，AUD的患病率在21岁之前达到顶峰。然而， 尽管有临床需求，但对青少年的AUD治疗依赖于心理社会干预，但收效甚微。 福利。改善青少年酒精治疗的一个潜在方法是增加现有的最好的 通过创新的数字健康解决方案进行心理社会干预。

PROJECT SUMMARY/ABSTRACT This K24 midcareer research and mentoring program aims to provide the candidate with protected time from direct patient care to conduct patient-oriented research (POR) on adolescent alcohol misuse and to mentor early-career clinical investigators in translational research in addiction science. To meet the challenge of advancing treatment options for the millions of American youth who struggle to reduce their alcohol use, the field requires highly trained researchers who can integrate cutting-edge concepts and methods from a variety of areas. As our understanding of addiction has become more complex, so too has the training needs of early- career scientists. For more than two decades, the candidate has built a productive and continuously funded POR program that translates theory-driven hypotheses from preclinical and human laboratory research to real world applications. The proposed integrated plan will facilitate the candidate’s ability to mentor early-career clinical investigators in POR and augment his capabilities as an independent clinician scientist. The research plan, which focuses on improving treatment options for adolescent alcohol misuse through digital health, dovetails the mentoring goals by providing a vehicle for mentoring early career scientists in: i) mechanisms of alcohol use disorder pathogenesis and treatment effects, ii) clinical trial methods, iii) ecological momentary assessment approaches, and iv) training in the responsible conduct of research. The candidate’s goal is to further develop and refine an experimental therapeutics approach that yields high quality information to inform decisions about whether further development of novel treatments is warranted. This K24 will support the collection of pilot data for an integrative digital health platform based on gold standard psychosocial interventions for treating AUD among adolescents. Adolescence is a critical period for the pathogenesis of AUD. Alcohol use typically begins during adolescence and prevalence rates for AUD peak before age 21. Yet, despite clinical demand, AUD treatments for youth rely on psychosocial interventions that yield only modest benefits. One potential way to improve adolescent alcohol treatment is to augment the best available psychosocial interventions with innovative digital health solutions.