Advanced Platform Technology Center

先进平台技术中心

• 批准号: 10665039
• 负责人: Gilles Pinault
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10665039
• 关键词: Acceleration; Address; Amputation; Amputees; Animals; Area; Articulation; Award; Basic Science; Bladder; Blood; Brain Injuries; Cardiopulmonary; Clinical; Clinical Services; Cognitive deficits; Collaborations; Communication; Communities; Computer software; Contracts; Dedications; Development; Devices; Diabetes Mellitus; Diabetic Neuropathies; Diagnostic; Disabled Persons; Discipline; Electric Stimulation Therapy; Electrodes; Engineering; Esthesia; Exercise; Femur; Functional disorder; Funding; Generations; Health; Human; Impaired cognition; Implant; Incontinence; Industrialization; Inflammatory Response; Intellectual Property; Intervention; Journals; Limb Prosthesis; Limb structure; Locomotion; Lower Extremity; Maintenance; Manufacturer; Medical center; Mentors; Methodology; Methods; Microfluidics; Monitor; Nervous System; Orthotic Devices; Outsourcing; Paralysed; Peer Review; Phantom Limb Pain; Point-of-Care Systems; Privatization; Process; Productivity; Program Evaluation; Prosthesis; Quality Control; Recovery; Rehabilitation therapy; Research Personnel; Resources; Robotics; Scientist; Secure; Self-Help Devices; Sensory; Site; Structure; System; Talents; Technology; Translations; United States National Institutes of Health; Upper Extremity; Veterans; advanced system; artificial lung; brain computer interface; chronic pain; clinical application; clinical implementation; clinical translation; daily functioning; design; exoskeleton; fabrication; feasibility testing; first-in-human; improved; innovation; lens; limb loss; meetings; microsystems; motor deficit; motor disorder; neural; neuroprosthesis; novel; outreach; pressure; programs; pulmonary function; research and development; research clinical testing; service organization; supportive environment; technology platform; wireless; wireless sensor; wound healing

The Advanced Platform Technology (APT) Center addresses the pressing clinical needs of disabled Veterans by harnessing the most recent developments in untapped engineering and basic science disciplines, and applying them to design and disseminate new rehabilitation interventions. The Center facilitates the creation and clinical translation of novel, cross cutting devices or methodologies within a framework that promotes regulatory compliance, outsourcing by contract manufacturers, clinical testing, and dissemination throughout the rehabilitation community. Its unique and supportive environment enables VA investigators to develop advanced assistive or restorative technologies that serve Veterans with sensory, motor, or cognitive deficits, as well as limb loss. The Center capitalizes on significant local expertise in pursuit of research and development activities in three main clinical Application Areas: Prosthetics & Orthotics, Health Monitoring & Maintenance, and Neural Interfacing. Innovative devices and foundational technical resources for the new treatment paradigms to progress from proof-of-concept through first-in-man clinical feasibility testing in these areas are developed by the Center’s Enabling Technology core. Center projects address new materials and microsystems for communicating with the nervous system for novel neurotherapeutic or neuroprosthetic interventions, mechanisms and optimal delivery of electrotherapy to accelerate wound healing or modulate chronic pain, novel sensing systems for point-of-care blood analysis and personalized health, replacing or restoring limb and pulmonary function, long-term monitoring of bladder status through wireless sensors, novel active exoskeletons and articulated support structures that enable locomotion and stair climbing, and advanced neurally-integrated prostheses to restore sensation to upper or lower limb amputees. The Center has established the internal engineering, quality control, and regulatory systems required for successful translation of its discoveries to clinical implementation. Center programs facilitate generation and protection of original intellectual properties, encourage interactions with the clinical services at the local medical center, and identify, mentor, and retain talented clinician-scientists dedicated to improving Veterans health. APT Investigators secure significant independent support from multiple local, national, governmental, and private agencies, including major awards from NIH, DARPA, NSF, and DoD, in addition to Merit Review and other VA funding, and disseminate their findings broadly in prestigious peer-reviewed journals, clinical and scientific meetings, and the lay media. The Center also empanels Clinical and Industrial Advisory Boards, and other mechanisms of governance and program evaluation that include representatives from Veterans Service Organizations, to actively create productive collaborations with academic and commercial partners. The Center established LSCVAMC as a site in the VA Innovator’s Network, and receives Spark, Seed, and Spread level funding to facilitate sharing its developments with other VA Medical Centers. An internal pilot funding program also selects and supports promising studies that have the potential to ultimately lead to independent funding and commercial translation of projects important to disabled Veterans. Priorities for the coming five years include: 1) Transitioning wireless bladder pressure monitoring, adaptive electrotherapeutic devices into humans, and microfluidic artificial lungs into large animal trials, 2) Deploying new, fully implanted systems for advanced sensorimotor enabled robotic upper limb prostheses and restoring plantar pressure sensation to trans-femoral amputees, 3) Addressing phantom pain in amputees and normalizing sensation in Veterans with diabetic neuropathies, 4) Exploring personalized game-based vestibular rehabilitation and enhancing access to adapted exercise, 5) Prolonging the functionality of cortical recording electrodes for brain computer interfaces and enhancing recovery from toxic brain injury by mitigating inflammatory responses, and 6) Expanding outreach, Veteran engagement, and capacity building activities.

先进平台技术（APT）中心解决残疾人迫切的临床需求 退伍军人通过利用未开发的工程和基础科学学科的最新发展， 并将其应用于设计和传播新的康复干预措施。该中心为 在一个框架内创建和临床翻译新的、跨领域的器械或方法， 促进法规遵从性、合同制造商的外包、临床试验和传播 整个康复社区。其独特的支持性环境使VA调查人员能够 开发先进的辅助或恢复技术，为退伍军人提供感官，运动或认知 缺陷以及肢体缺失。该中心利用重要的当地专业知识进行研究， 在三个主要临床应用领域开展开发活动：假肢和矫形，健康监测和 维护和神经接口。创新设备和基础技术资源， 治疗范例从概念验证到首次人体临床可行性测试， 这些领域由该中心的使能技术核心开发。中心项目涉及新材料和 用于新型神经治疗或神经修复的与神经系统通信的微系统 电疗法的干预、机制和最佳递送以加速伤口愈合或调节 慢性疼痛，用于即时血液分析和个性化健康的新型传感系统， 恢复肢体和肺功能，通过无线传感器长期监测膀胱状态， 主动外骨骼和铰接支撑结构，使运动和爬楼梯，和先进的 神经整合假体，以恢复上肢或下肢截肢者的感觉。 中心建立了内部工程、质量控制和监管体系， 将其发现成功转化为临床应用。中心方案促进了生产和 保护原创知识产权，鼓励与当地临床服务机构的互动 医疗中心，并确定，导师，并保留有才华的临床科学家致力于改善退伍军人 健康APT调查人员从多个地方，国家，政府， 和私人机构，包括来自NIH、DARPA、NSF和DoD的主要奖项，以及Merit Review 和其他VA资金，并在着名的同行评审期刊，临床和 科学会议和媒体。该中心还设立了临床和工业咨询委员会， 包括退伍军人服务代表在内的其他治理和项目评估机制 组织，积极与学术和商业合作伙伴建立富有成效的合作。中心 建立LSCVAMC作为VA创新者网络中的一个站点，并获得Spark，Seed和Spread级别 资金，以促进与其他VA医疗中心分享其发展。内部试点资助计划 还选择和支持有前途的研究，有可能最终导致独立的资金 和商业翻译项目的重要残疾退伍军人。 未来五年的优先事项包括：1）过渡无线膀胱压力监测，自适应 电疗设备进入人体，微流体人工肺进入大型动物试验，2）部署 用于先进的感觉运动机器人上肢假肢和恢复的新型完全植入式系统 经股截肢者的足底压力感觉，3）解决截肢者的幻痛， 糖尿病神经病变退伍军人的感觉正常化，4）探索个性化的基于游戏的前庭 5）延长皮层记录功能 脑计算机接口的电极，并通过减轻 炎症反应，以及6）扩大外展，退伍军人参与和能力建设活动。

项目成果

Polymer Additives to Personal Protective Equipment can Inactivate Pathogens.

• DOI: 10.1007/s10439-022-03100-1
• 发表时间: 2023-04
• 期刊: ANNALS OF BIOMEDICAL ENGINEERING
• 影响因子: 3.8
• 作者: Dogan, Alan B.;Dabkowski, Katherine E.;Cadnum, Jennifer L.;Donskey, Curtis J.;von Recum, Horst A.
• 通讯作者: von Recum, Horst A.

Multi-center, single-blind randomized controlled trial comparing functional electrical stimulation therapy to conventional therapy in incomplete tetraplegia.

• DOI: 10.3389/fresc.2022.995244
• 发表时间: 2022
• 期刊: FRONTIERS IN REHABILITATION SCIENCES
• 作者: Anderson, Kim D.;Korupolu, Radha;Musselman, Kristin E.;Pierce, Jacqueline;Wilson, James R.;Yozbatiran, Nuray;Desai, Naaz;Popovic, Milos R.;Thabane, Lehana
• 通讯作者: Thabane, Lehana