Advanced Platform Technology Center

先进平台技术中心

• 批准号: 10663771
• 负责人: Gilles Pinault
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10663771
• 关键词: Address; Amputation; Amputees; Animals; Area; Award; Basic Science; Bladder; Blood; Brain Injuries; Cardiopulmonary; Clinical; Clinical Services; Cognitive deficits; Collaborations; Communities; Computer software; Contracts; Development; Devices; Diabetes Mellitus; Diabetic Neuropathies; Diagnostic; Disabled Persons; Discipline; Electric Stimulation Therapy; Electrodes; Engineering; Esthesia; Exercise; Federal Government; Foundations; Functional disorder; Funding; Generations; Health; Human; Impaired cognition; Implant; Incontinence; Industrialization; Inflammatory Response; Intellectual Property; Intervention; Journals; Lead; Limb Prosthesis; Limb structure; Locomotion; Lower Extremity; Maintenance; Manufacturer Name; Medical center; Mentors; Methodology; Methods; Microfluidics; Monitor; Nervous system structure; Orthotic Devices; Outsourcing; Paralysed; Peer Review; Phantom Limb Pain; Point-of-Care Systems; Privatization; Process; Program Evaluation; Prosthesis; Quality Control; Recovery; Rehabilitation therapy; Research Personnel; Resources; Robotics; Scientist; Secure; Seeds; Self-Help Devices; Sensory; Site; Structure; System; Talents; Technology; Translations; United States National Institutes of Health; Upper Extremity; Veterans; advanced system; artificial lung; base; brain computer interface; chronic pain; clinical application; clinical implementation; clinical translation; daily functioning; design; exoskeleton; feasibility testing; first-in-human; improved; innovation; lens; limb loss; meetings; microsystems; motor deficit; motor disorder; neuroprosthesis; novel; outreach; pressure; programs; pulmonary function; relating to nervous system; research and development; research clinical testing; service organization; supportive environment; wireless; wireless sensor; wound healing

The Advanced Platform Technology (APT) Center addresses the pressing clinical needs of disabled Veterans by harnessing the most recent developments in untapped engineering and basic science disciplines, and applying them to design and disseminate new rehabilitation interventions. The Center facilitates the creation and clinical translation of novel, cross cutting devices or methodologies within a framework that promotes regulatory compliance, outsourcing by contract manufacturers, clinical testing, and dissemination throughout the rehabilitation community. Its unique and supportive environment enables VA investigators to develop advanced assistive or restorative technologies that serve Veterans with sensory, motor, or cognitive deficits, as well as limb loss. The Center capitalizes on significant local expertise in pursuit of research and development activities in three main clinical Application Areas: Prosthetics & Orthotics, Health Monitoring & Maintenance, and Neural Interfacing. Innovative devices and foundational technical resources for the new treatment paradigms to progress from proof-of-concept through first-in-man clinical feasibility testing in these areas are developed by the Center’s Enabling Technology core. Center projects address new materials and microsystems for communicating with the nervous system for novel neurotherapeutic or neuroprosthetic interventions, mechanisms and optimal delivery of electrotherapy to accelerate wound healing or modulate chronic pain, novel sensing systems for point-of-care blood analysis and personalized health, replacing or restoring limb and pulmonary function, long-term monitoring of bladder status through wireless sensors, novel active exoskeletons and articulated support structures that enable locomotion and stair climbing, and advanced neurally-integrated prostheses to restore sensation to upper or lower limb amputees. The Center has established the internal engineering, quality control, and regulatory systems required for successful translation of its discoveries to clinical implementation. Center programs facilitate generation and protection of original intellectual properties, encourage interactions with the clinical services at the local medical center, and identify, mentor, and retain talented clinician-scientists dedicated to improving Veterans health. APT Investigators secure significant independent support from multiple local, national, governmental, and private agencies, including major awards from NIH, DARPA, NSF, and DoD, in addition to Merit Review and other VA funding, and disseminate their findings broadly in prestigious peer-reviewed journals, clinical and scientific meetings, and the lay media. The Center also empanels Clinical and Industrial Advisory Boards, and other mechanisms of governance and program evaluation that include representatives from Veterans Service Organizations, to actively create productive collaborations with academic and commercial partners. The Center established LSCVAMC as a site in the VA Innovator’s Network, and receives Spark, Seed, and Spread level funding to facilitate sharing its developments with other VA Medical Centers. An internal pilot funding program also selects and supports promising studies that have the potential to ultimately lead to independent funding and commercial translation of projects important to disabled Veterans. Priorities for the coming five years include: 1) Transitioning wireless bladder pressure monitoring, adaptive electrotherapeutic devices into humans, and microfluidic artificial lungs into large animal trials, 2) Deploying new, fully implanted systems for advanced sensorimotor enabled robotic upper limb prostheses and restoring plantar pressure sensation to trans-femoral amputees, 3) Addressing phantom pain in amputees and normalizing sensation in Veterans with diabetic neuropathies, 4) Exploring personalized game-based vestibular rehabilitation and enhancing access to adapted exercise, 5) Prolonging the functionality of cortical recording electrodes for brain computer interfaces and enhancing recovery from toxic brain injury by mitigating inflammatory responses, and 6) Expanding outreach, Veteran engagement, and capacity building activities.

先进平台技术 (APT) 中心满足残疾人的迫切临床需求 退伍军人通过利用未开发的工程和基础科学学科的最新发展， 并将其应用于设计和传播新的康复干预措施。该中心有利于 在一个框架内创建和临床转化新颖的、跨领域的设备或方法 促进法规遵从、合同制造商外包、临床测试和传播 整个康复社区。其独特的支持性环境使 VA 调查人员能够 开发先进的辅助或恢复技术，为退伍军人提供感觉、运动或认知服务 缺陷，以及肢体丧失。该中心利用重要的当地专业知识进行研究和 三个主要临床应用领域的开发活动：假肢和矫形器、健康监测和 维护和神经接口。新的创新设备和基础技术资源 治疗范例从概念验证到首次人体临床可行性测试 这些领域由该中心的支持技术核心开发。中心项目涉及新材料和 用于与神经系统通信的新型神经治疗或神经假体的微系统 加速伤口愈合或调节的干预措施、机制和最佳电疗实施 慢性疼痛、用于护理点血液分析和个性化健康的新型传感系统、替代或 恢复肢体和肺功能，通过无线传感器长期监测膀胱状态，新颖 主动外骨骼和铰接式支撑结构，可实现运动和爬楼梯，以及先进的 神经整合假肢，用于恢复上肢或下肢截肢者的感觉。 中心建立了所需的内部工程、质量控制和监管体系 其发现成功转化为临床实施。中心计划促进生成和 保护原创知识产权，鼓励与当地临床服务机构的互动 医疗中心，并识别、指导和留住致力于改善退伍军人的有才华的临床医生科学家 健康。 APT 调查人员获得了来自多个地方、国家、政府、 和私人机构，包括来自 NIH、DARPA、NSF 和 DoD 的主要奖项，以及优异评审 和其他 VA 资助，并在著名的同行评审期刊、临床和 科学会议和普通媒体。该中心还组建了临床和工业咨询委员会，以及 其他治理和计划评估机制，包括退伍军人服务部的代表 组织，积极与学术和商业合作伙伴建立富有成效的合作。中心 将 LSCVAMC 建立为 VA 创新者网络中的站点，并获得 Spark、Seed 和 Spread 级别 资金以促进与其他退伍军人管理局医疗中心分享其发展成果。内部试点资助计划 还选择并支持有潜力的研究，这些研究有可能最终获得独立资助 以及对残疾退伍军人重要的项目的商业翻译。 未来五年的优先事项包括： 1) 过渡无线膀胱压力监测、自适应 将电疗装置应用于人体，将微流体人工肺应用于大型动物试验，2) 部署 全新的完全植入系统，用于先进的感觉运动功能的机器人上肢假肢和恢复 为经股截肢者提供足底压力感觉，3) 解决截肢者的幻痛问题 使患有糖尿病神经病的退伍军人的感觉正常化，4) 探索基于游戏的个性化前庭 康复和增强适应性运动的机会，5）延长皮质记录的功能 用于脑机接口的电极，通过减轻中毒性脑损伤来促进中毒性脑损伤的恢复 炎症反应，以及 6) 扩大外展范围、退伍军人参与和能力建设活动。