Advancing Native American Diversity in Aging Research through Undergraduate Education (Native American ADAR)

项目总结 该应用程序响应PAR-17-290，寻求25卢比的资金用于“推进原住民 美国通过本科教育进行老龄化研究的多样性。通过提供 年度课程和指导性研究-以及在线虚拟教育和指导 这次新冠肺炎大流行-我们招收有美国原住民背景的学生，既有城市背景的 和非城市，以鼓励他们追求研究阿尔茨海默氏症和 相关痴呆症(ADRD)和衰老机制，并有助于启动他们的科学生涯。 ADRD和老龄化领域继续快速增长，老年人口也是如此，但有 由代表不足的少数民族(URM)科学家领导的实验室太少，更不用说土著科学家了 美国的PI，以及太少的新的URM实习生。这部R25由Gerald Schatten博士执导 和Laura Niedernhofer，医学博士，博士(明尼苏达州)，他们加入了David Burgess，博士(切诺基， 波士顿学院)；Melissa Wells博士(Bois Forte&Couchiching First Nation Anishinaabe，Johns 霍普金斯-德卢斯)；保罗·罗宾斯，博士(明尼苏达州)；卡尔文·西姆利，博士(皮特) 执行委员会。该课程在明尼苏达州的衰老生物学研究所举行 新陈代谢，由Laura Niedernhofer，医学博士和Paul Robbins博士指导。每天的讲座， 主动学习，扩展对新兴概念的讨论，然后是实验室和小组 演习和非正式研讨会为期一周(2021年8月15日至21日)。既有实践经验，又有 为16名参与者提供关于ADRD根本原因和最新发现的在线培训 介绍治疗方法，特别关注美洲原住民；衰老生物学 也被考虑了。之后与每个学员保持频繁的互动，以进行评估 并提供持续的指导。对部落历史敏感地进行，五个 提出了具体目标：一、提供反兴奋剂机构的概念教育和研究培训； 老龄化生物学，与美洲原住民受训人员相关；II.支持有指导的飞行员 研究，特别是涉及与土著有关的健康差距和多样性方面的挑战 鼓励学员和校友通过个人的方式进行更长期的职业规划 辅导、辅导会议和点对点建议；IV.讨论NIH的法规要求 在部落主权的背景下；和五.评估、改进和监测土著 美国ADAR的优势和劣势以不偏不倚、量化、独立 跟踪受训者和校友成就的机制，以确保该计划是 明智、高性价比的投资。在这样做的过程中，我们将加强和扩大 有前途的受训人员，特别是美洲原住民，帮助确保NIA和NIH的完全多样性。

PROJECT SUMMARY This application, responsive to PAR-17-290, seeks R25 funding for “Advancing Native American Diversity in Aging Research through Undergraduate Education.” By offering annual courses and mentored research—along with online virtual education and mentoring during this COVID-19 pandemic—we recruit students from Native American backgrounds, both urban and non-urban, to encourage them to pursue careers investigating Alzheimer’s disease and related dementias (ADRD) and aging mechanisms, and help to launch their scientific careers. The ADRD and aging fields continue to grow swiftly, as does the elderly population, yet there are too few laboratories led by under-represented minority (URM) scientists, let alone Native American PIs, and too few new URM trainees. This R25 is directed by Gerald Schatten, PhD (Pitt), and Laura Niedernhofer, MD, PhD (Minnesota), who join David Burgess, PhD (Cherokee, Boston College); Melissa Wells, PhD (Bois Forte & Couchiching First Nation Anishinaabe, Johns Hopkins - Duluth); Paul Robbins, PhD (Minnesota); and Calvin Simerly, PhD (Pitt) as the Executive Committee. The course is held at Minnesota’s Institute on the Biology of Aging and Metabolism, directed by Laura Niedernhofer, MD, PhD, and Paul Robbins, PhD. Daily lectures, active learning, and extended discussions on emerging concepts, followed by lab and group exercises and informal seminars are held over a week (August 15-21, 2021). Both hands-on and online training for 16 participants on recent discoveries regarding ADRD’s root causes and treatments is presented, with special attention devoted to Native Americans; the biology of aging is also considered. Frequent interactions are maintained with each trainee afterwards, to evaluate the course and provide ongoing mentoring. Conducted with sensitivity to tribal histories, five specific aims are proposed: I. Provide conceptual education and research training in ADRD and the Biology of Aging, with relevance for Native American trainees; II. Support mentored pilot research, especially involving challenges in health disparities and diversity related to Native Americans; III. Encourage trainees’ and alumni’s longer-term career planning through personal coaching, mentoring sessions, and peer-to-peer advice; IV. Discuss NIH regulatory requirements within the context of Tribal Sovereignty; and V. Evaluate, improve, and monitor the Native American ADAR’s strengths and avoid weaknesses with unbiased, quantitative, independent mechanisms which track trainees’ and alumni’s achievements to ensure that the program is a wise, cost-effective investment. In so doing, we will enhance and expand the research careers of promising trainees, especially Native Americans, to help ensure full diversity in the NIA and NIH.