Developing a Community-Based Facility to Support Next Generation Biomedical HIV Research

项目摘要/摘要 华盛顿特区的7号和8号区是美国最严重的种族不平等现象的发源地 社会经济指标，这些病房的居民在医疗保健和 公共卫生研究的代表性不足。在这些健康不平等中，艾滋病毒的负担要高得多， 然而，华盛顿特区与艾滋病毒有关的主要研究机构都不在这些病房内。两个中心枢纽 DC内的艾滋病毒研究-DC艾滋病研究中心和DC临床试验单位-都在运作 主要是在2号病房的设施外，这项研究的有效性将通过更强的 边缘化社区在议定书中的代表性，以优化这项工作对 华盛顿特区受艾滋病毒及其共病/共感染和其他共生疾病影响最严重的社区 健康不平等。因此，拟议的艾滋病毒研究设施奖的目标是资助一个新的 最先进的、以社区为中心的艾滋病毒临床和翻译研究设施位于新的 华盛顿特区8号病房的惠特曼-沃克旗舰建筑目前正在建设中，将与艾滋病毒联合使用 惠特曼-沃克和乔治华盛顿大学(GWU)的调查人员。拟议的设施将 增加10300平方英尺的专用研究空间，包括一个最先进的研究实验室和一个研究 具有研究产品无菌合成能力的药房，是现有药房的两倍多 这座建筑中的研究空间，是#年以艾滋病毒为重点的研究的主要协作中心 哥伦比亚特区东南部。这样做将显著：(1)增加能够进行的研究的总体数量；(2) 加强惠特曼-沃克和GWU调查人员的合作，支持 两个研究计划；(3)扩大工作范围和技术能力，这不仅是可能的 对于这两个机构，也在这些特定的华盛顿社区内；(4)间接扩大可用的 社会/行为和公共卫生研究的空间，以及通过重新定位所有临床和翻译 对新设施进行研究；(5)为当地社区提供更多参与切割的机会和代表性- 前沿艾滋病毒科学和新机会，帮助为这些合作研究议程提供信息；(6)促进 在地方和国家政策范围内更好地翻译和传播艾滋病毒科学的突破 这将使当地的DC社区和全国的社区都受益；以及(7)促进新的 培训和指导的机会。总而言之，拟议的项目将对两者产生倍增的影响 通过这一独特的计划进行地方和国家艾滋病毒研究，以扩大现有设施的规模和范围 并将DC的两个顶级艾滋病毒研究机构置于同一地点，以利用现有的合作伙伴关系并打造新的、 以社区为中心的协作研究议程。通过这样做，该奖项将带来尖端技术 艾滋病毒治疗和预防科学的突破直接惠及受影响最严重的服务不足的社区 艾滋病毒在哥伦比亚特区的流行，对未来几十年的公共卫生有重大的潜在影响。

Project Summary/Abstract Wards 7 and 8 in Washington, DC are home to some of the nation’s most stark racial inequities in health and socioeconomic indicators, with residents of these wards being underserved in healthcare and underrepresented public health research. Among these health inequities is a significantly higher burden of HIV, yet none of the major HIV-related research facilities in DC are located within these wards. Two central hubs for HIV research within DC—the DC Center for AIDS Research and the DC Clinical Trials Unit—both operate primarily out of facilities in Ward 2, and the efficacy of this research would be enhanced by stronger representation of marginalized communities in protocols to optimize the impact of this work on the neighborhoods in DC that are the hardest hit by HIV, its co-morbidities/co-infections, and other co-occurring health inequities. Thus, the goal of the proposed HIV research facilities award is to fund the build-out of a new state-of-the-art, community-centered clinical and translational HIV research facility located within the new flagship Whitman-Walker building currently being constructed in DC’s Ward 8, to be used jointly by HIV investigators at both Whitman-Walker and George Washington University (GWU). The proposed facility would add 10,300 square feet of dedicated research space, including a state-of-the-art research lab and a research pharmacy with capacity for sterile compounding of investigational products, more than doubling the available space for research in this building and serving as the primary collaborative hub for HIV-focused research in Southeast DC. Doing so will significantly: (1) increase the overall volume of research able to be conducted; (2) enhance the collaboration of Whitman-Walker and GWU investigators, bolstering the strategic integration of both research programs; (3) expand the scope and technical capabilities of the work that is possible not only for both institutions but also within these specific neighborhoods of DC; (4) indirectly expand the available space for social/behavioral and public health research as well by relocating all clinical and translational research to the new facility; (5) provide local communities with greater access to and representation in cutting- edge HIV science and new opportunities to help inform these collaborative research agendas; (6) facilitate greater translation and dissemination of breakthroughs in HIV science within local and national policy contexts that will benefit both local DC communities and communities across the country; and (7) promote new opportunities for training and mentorship. In sum, the proposed project will have a multiplicative impact on both local and national HIV research through this unique plan to increase the size and scope of facilities available and co-locate two of DC’s top HIV research institutions to leverage existing partnerships and forge new, community-centered collaborative research agendas. In doing so, the award will bring cutting-edge breakthroughs in HIV treatment and prevention science directly to underserved communities most impacted by the HIV epidemic in DC and has significant potential for public health impact for decades to come.