Discreet Wearable device for Continuous Real-time Monitoring of Alcohol
用于连续实时监测酒精浓度的谨慎可穿戴设备
基本信息
- 批准号:10547664
- 负责人:
- 金额:$ 38.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:AgeAlcohol consumptionAlcoholsAlgorithmsAnodesBacterial Artificial ChromosomesBiological AssayBiosensing TechniquesBiosensorBloodBlood alcohol level measurementBody measure procedureCaliberCalibrationCause of DeathCenters for Disease Control and Prevention (U.S.)Cessation of lifeChemicalsChemistryClinicClinicalClinical ResearchCoupledCustomDataData DisplayDetectionDevelopmentDevicesDoseDrug Rehabilitation CentersEconomic FactorsElectronicsEnzymesEthnic groupFaceFeasibility StudiesForensic MedicineGenderGoalsGovernmentHeavy DrinkingHospitalsHourHumanHydrogen PeroxideImmobilizationIn VitroIntercellular FluidLaboratoriesLifeMeasurementMeasuresMechanicsMethodsMicroinjectionsMissionModificationMoldsNational Institute on Alcohol Abuse and AlcoholismNoisePain-FreePainlessPenetrationPerformancePhasePolymersPopulation HeterogeneityRaceReportingReproducibilityResearchSecureSeriesSignal TransductionSkinSmall Business Innovation Research GrantSterilizationStructureSystemTestingThickTimeUnited StatesValidationVariantVenousVisualizationWorkWorld Health Organizationalcohol measurementalcohol monitoringalcohol oxidasealcohol related problemalcohol responsealcohol use disorderattributable mortalitybasebiomaterial compatibilitybody sensecommercializationcostcytotoxicitydesigndisabilitydrug testingenzyme activityfeasibility testinghealth economicshuman subjectinnovationinnovative technologiesinterestminiaturizeminiaturized devicemobile applicationmonitoring devicenoveloperationoxidationprinted circuit boardprogramsprospectiveprototypepublic health relevancereal time monitoringresearch clinical testingresponsesensorsensor technologytrial designvaporwearable devicewearable sensor technologywireless
项目摘要
Abstract
Excessive alcohol use remains a leading preventable cause of death and disability in the United States.
According to the Centers for Disease Control and Prevention (CDC), an average of 95,158 alcohol-attributable
deaths (261 deaths per day) is reported only in the United States, with associated annual costs of $249 billion.
The goal of this project is to develop a wearable integrated device capable of continuously measuring, recording,
and storing ISF alcohol levels in real-time without the need for external calibrations. The National Institute on
Alcohol Abuse and Alcoholism (NIAAA) seeks a wearable alcohol monitoring device that can continuously
measure real-time alcohol levels in the blood or interstitial fluid (ISF), and this proposal is highly aligned with the
NIAAA’s mission. An accurate wearable alcohol sensor will serve useful purposes in different settings, including
research programs, clinics, forensic applications, and consumer use to promote responsible alcohol
consumption. The available transdermal alcohol monitoring devices, relying on alcohol detection in sweat or
sweat vapor, face significant problems such as long lag times (up to several hours) and tend to be cumbersome.
In this context, ActioX, LLC has developed a non-obtrusive wearable sensor platform to enable pain-free analysis
few hundred microns under the skin, directly in the ISF. The novel sensing technology relies on a biocompatible
array of microneedles, optimized for painless skin penetration, and thus to provide continuous access to
constantly revitalizing ISF. This fully integrated wirelessly operated device is composed of two components of a
reusable electronics and a disposable microneedle array, along with a successful demonstration of a custom-
designed app for data capture and visualization. Our preliminary data using the prototype device showed
successful real-time tracking of ISF alcohol in response to alcohol drinking episodes in multiple human subjects,
with the results well correlated to those from a breathalyzer. This SBIR Fast-Track project will leverage this
innovative technology to develop a discreet, real-time, continuous, and calibration-free continuous alcohol
monitoring device toward prolonged on-body operations to enable more comprehensive and accurate clinical
studies and allow efficient control and management of alcohol-related problems, including alcohol use disorder.
Phase I constitutes in-vitro feasibility studies to find the best chemical modification strategy with optimal
sensitivity, selectivity, reproducibility, and extended 3-days stability. We aim in Phase II to execute a series of
clinical studies to develop a prospective calibration algorithm that can convert, in real time, the raw
electrochemical sensor signals to BAC. The data gathered through this work will support FDA clearance, and
subsequently, the commercialization of our real-time, continuous alcohol monitoring wearable system as a
reliable and accurate device ready to be used by end users, including hospitals, drug rehabilitation centers, drug
testing laboratories, government departments, and others.
摘要
项目成果
期刊论文数量(0)
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Farshad Tehrani其他文献
Farshad Tehrani的其他文献
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{{ truncateString('Farshad Tehrani', 18)}}的其他基金
Discreet Wearable device for Continuous Real-time Monitoring of Alcohol
用于连续实时监测酒精浓度的谨慎可穿戴设备
- 批准号:
10872334 - 财政年份:2023
- 资助金额:
$ 38.43万 - 项目类别:
A wearable device for continuous monitoring of methadone
用于连续监测美沙酮的可穿戴设备
- 批准号:
10787069 - 财政年份:2023
- 资助金额:
$ 38.43万 - 项目类别:
A Sensor Patch for Continuous Monitoring of Sodium, Glucose, and Ketones Concurrently and in Real-Time
用于同时实时连续监测钠、葡萄糖和酮的传感器贴片
- 批准号:
10761499 - 财政年份:2023
- 资助金额:
$ 38.43万 - 项目类别:
Discreet Wearable device for Continuous Real-time Monitoring of Alcohol
用于连续实时监测酒精浓度的谨慎可穿戴设备
- 批准号:
10786387 - 财政年份:2022
- 资助金额:
$ 38.43万 - 项目类别:
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