Development of Ingestible Biosensors to Enhance PrEP Adherence in Substance Users

开发可摄入生物传感器以增强药物使用者的 PrEP 依从性

• 批准号: 10674107
• 负责人: Peter R Chai
• 金额: $ 6.75万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10674107
• 关键词: AIDS prevention; Address; Adherence; Administrative Supplement; Affect; Automobile Driving; Award; Biosensor; Chemoprophylaxis; Chronic; Clinical; Clinical Trials; Cognitive Therapy; Communities; Companions; Consolidated Framework for Implementation Research; Development; Devices; Discrimination; Effectiveness; Effectiveness of Interventions; Epidemic; Evaluation; Gelatin; Goals; Growth; HIV; HIV risk; Health Personnel; Health behavior; Health system; Incidence; Individual; Ingestion; Intervention; Intervention Trial; Interview; Lead; Link; Measurement; Measures; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Minority; Modeling; Moods; Oral; Outcome Study; Parents; Participant; Pattern; Population; Positioning Attribute; Randomized Controlled Trials; Reader; Risk; Risk Behaviors; Sampling Studies; Science; Signal Transduction; Site; Stomach; Stress; Substance Use Disorder; System; Technology; Tenofovir; Textiles; Time; United States; Work; affective disturbance; capsule; digital; emtricitabine; experience; feasibility testing; follow-up; health disparity; implementation determinants; implementation intervention; improved; indexing; innovation; lens; men who have sex with men; minority stress; multidisciplinary; novel; oral HIV; pill; prevention clinical trial; preventive intervention; primary outcome; psychological distress; radio frequency; response; sexual identity; sexual minority; skills; skills training; social exclusion; social stigma; substance user; supervised learning; technology development; therapy adherence; therapy development; tool; uptake

ABSTRACT The HIV epidemic continues to disproportionately affect individuals with health disparities. Marginalization, substance use disorder, stigma and other health disparities contribute to decreased mood which influences key health behaviors like adherence to oral HIV pre-exposure chemoprophylaxis (PrEP). These key disparities contributed to the world failing to achieve the UNAIDS 90-90-90 goals in 2020 to end the HIV epidemic. One of the pillars to ending the epidemic is improving uptake and persistent to PrEP. While efficacious, men who have sex with men (MSM) with substance use disorders (SUD) experience multiple intersectional marginalized identities which lead to PrEP nonadherence. Technologies to detect PrEP adherence patterns continue to be developed to advance interventions that support adherence. The parent award, K23DA044874, develops a preventive intervention, PrEPSteps, that leverages an ingestible radiofrequency transmitter (digital pill system) to directly measure adherence. This digital pill then drives personalized adherence skills training that addresses PrEP nonadherence at the moment it occurs. In this administrative supplement, we will integrate measures of health disparities including the intersectional discrimination index and profile of mood states into the fabric of the parent pilot randomized controlled trial to understand mechanisms of how these health disparities influence uptake of the digital pill intervention and PrEP adherence. We will additionally conduct formative qualitative interviews among parent study participants and healthcare providers who prescribed PrEP grounded in the Consolidated Framework for Implementation Research (CFIR) to understand how health systems may implement digital pills to measure PrEP adherence with a lens of health disparities.

摘要 艾滋病毒流行病继续对健康状况不平等的个人产生不成比例的影响。边缘化， 物质使用障碍，耻辱和其他健康差异有助于降低情绪，影响关键 健康行为，如坚持口服艾滋病毒暴露前化学预防（PrEP）。这些关键的差异 导致世界未能实现联合国艾滋病规划署在2020年结束艾滋病毒流行的90-90-90目标。之一 结束这一流行病的支柱是提高对PrEP的吸收和坚持。虽然有效， 患有物质使用障碍（SUD）的男男性行为者（MSM）经历了多个交叉边缘化 导致PrEP不依从的身份。检测PrEP依从性模式的技术仍然是 制定了促进支持依从性的干预措施。母公司奖K23 DA 044874开发了一种 预防性干预，PrEPSteps，利用可摄入的射频发射器（数字药丸系统） 来直接测量依从性。这种数字药丸然后驱动个性化的坚持技能培训， 解决PrEP不依从的问题。在这份行政补充中，我们将整合 健康差异的措施，包括交叉歧视指数和情绪状态的概况， 父母试点随机对照试验的结构，以了解这些健康的机制， 差异影响数字药丸干预和PrEP依从性的摄取。我们还将进行 父母研究参与者和开PrEP处方的医疗保健提供者之间的形成性定性访谈 基于实施研究综合框架（CFIR），以了解健康 系统可以实现数字药丸以测量具有健康差异的透镜的PrEP依从性。

项目成果

Wastewater network infrastructure in public health: Applications and learnings from the COVID-19 pandemic.

• DOI: 10.1371/journal.pgph.0000061
• 发表时间: 2021-01-01
• 期刊: PLOS global public health
• 作者: Sharara, Nour;Endo, Noriko;Erickson, Timothy B
• 通讯作者: Erickson, Timothy B

Digital Biomarker Applications Across the Spectrum of Opioid Use Disorder.

• DOI: 10.1080/28324765.2023.2240375
• 发表时间: 2023-08
• 期刊: Cogent mental health
• 作者: M. Rigatti;Brittany P. Chapman;P. Chai;D. Smelson;K. Babu;Stephanie P Carreiro

Novichok agents: a historical, current, and toxicological perspective.

• DOI: 10.1080/24734306.2018.1475151
• 发表时间: 2018
• 期刊: Toxicology communications
• 作者: Chai PR;Hayes BD;Erickson TB;Boyer EW
• 通讯作者: Boyer EW

In Reply to "Hydroxychloroquine Overdose: What Are the Exact Roles of Diazepam and Potassium Infusion?"

回复“羟氯喹过量：地西泮和钾输注的确切作用是什么？”

• DOI: 10.1007/s13181-020-00812-5
• 发表时间: 2021
• 期刊: Journal of medical toxicology : official journal of the American College of Medical Toxicology
• 作者: Chai,PR;Ferro,EG;Kirshenbaum,JM;Hayes,BD;Culbreth,SE;Boyer,EW;Erickson,TB
• 通讯作者: Erickson,TB

An Internet of Things Buttons to Measure and Respond to Restroom Cleanliness in a Hospital Setting: Descriptive Study.

用于测量和响应医院环境中卫生间清洁度的物联网按钮：描述性研究。

• DOI: 10.2196/13588
• 发表时间: 2019
• 期刊: Journal of medical Internet research
• 影响因子: 7.4
• 作者: Chai,PeterR;Zhang,Haipeng;Jambaulikar,GuruprasadD;Boyer,EdwardW;Shrestha,Labina;Kitmitto,Loay;Wickner,PaigeG;Salmasian,Hojjat;Landman,AdamB
• 通讯作者: Landman,AdamB