权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Origins and Transformations of Signals for Circadian Regulation

昼夜节律调节信号的起源和转变

基本信息

批准号：
10548506
负责人：
Michael Tri Hoang Do
金额：
$ 4.9万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-05-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10548506
关键词：
Animals Behavioral Biophysics Brain Cardiovascular Diseases Cells Circadian Dysregulation Circadian Rhythms Cognition Color Communication Cues Electrophysiology (science)Environment Exhibits Exposure to Eye Foundations Frequencies Gene Expression Profile Goals Health Image Impairment In Vitro Inherited Jet Lag Syndrome Knowledge Learning Light Lighting Link Malignant Neoplasms Mediating Mental disorders Metabolic Diseases Methods Moods Motion Neurons Neurosciences Opsin Output Pathway interactions Pattern Perception Phase Photons Photosensitivity Physiological Physiology Planet Earth Preparation Presynaptic Terminals Process Prosthesis Design Proxy Regulation Retina Retinal Ganglion Cells Role Rotation Signal Transduction Stimulus Sum Testing Time Tissues Ursidae Family Vision Visual system structure Work cell type circadian circadian pacemaker circadian regulation experience experimental study in vivo insight millisecond neuronal cell body novel relating to nervous system response shift work sight restoration spatiotemporal suprachiasmatic nucleus

项目摘要

PROJECT SUMMARY The earth’s rotation drives profound changes in our environment. Practically every tissue of the body is synchronized to this rhythm by an internal timekeeping mechanism, the circadian clock. Desynchronization impairs mood, cognition, and physiology—commonly experienced in shift work and jet lag. Proper exposure to light realigns the clock with the solar day and can reverse these impairments. We have developed a new method to access the pathway that joins the eye with the master clock in the brain. We propose to define how information is generated within the retina and subsequently transformed as it enters clock circuitry. We expect to provide knowledge of how physiology is tuned to environmental cycles, and of the division of labor between retina and brain.

项目摘要地球的自转使我们的环境发生了深刻的变化。几乎身体的每一个组织通过内部的计时机制，生物钟，与这种节奏同步。去同步损害情绪、认知和生理--通常在轮班工作和时差中经历。适当暴露于光会使时钟与太阳日重新对齐，并能逆转这些缺陷。我们已经开发出一种新方法来访问连接眼睛和大脑中主时钟的路径。我们建议定义如何信息在视网膜内产生，并且随后在其进入时钟电路时被变换。我们预计提供生理学如何适应环境周期的知识，以及视网膜和大脑。