Behavior Core

行为核心建立在啮齿动物感官测试、药理学和 神经元的光遗传操作，临床前早期药物的发现和开发，以及基因分型和克隆 管理层。BC已经成为Cobre和非Cobre附属调查人员在 新英格兰大学(UNE)、地区和国家学术用户以及行业合作伙伴。在第三阶段，核心 将继续在这一多样化的用户基础上建立稳定可靠的收入流，目标是成为 为需要高质量活体测试的用户提供可持续的资源。委员会将继续提供(A)集中的 许多行为分析和手术程序的空间；(B)标准化方案和实验室之间的培训，以 减少变异性，提高行为分析的可重复性和有效性；(C)高级培训和模式 发展和验证(例如，反射性伤害反应的替代方案，如情感、认知和疼痛- 抑制读数)。新的发展包括扩大老鼠独立测试区的空间和设备，以及 小鼠，以增加吞吐量和减少潜在的混淆测试两个物种在同一地区，扩大 提供育种和基因分型服务，以支持提高转基因小鼠和大鼠模型的利用率；以及 支持研究人员在行为研究中使用光遗传学方法。核心研究的继续培训 将提供工作人员，以确保能够为行为核心用户提供最高水平的创新和支持。 来自内部和外部用户的用户反馈一直是高度积极的。核心人员已被包括在内 作为出版物和行为核心服务的作者，核心服务已被纳入NIH的拨款申请。续 对其能力的投资将使Core能够提供动物研究的最新实验工具，并帮助 向财政独立的核心过渡。注意到科布雷研究核心给联合国大学带来的价值，该机构 概述了在第三阶段资助期结束后至少5年内支持行为核心的承诺。 机构承诺包括专用实验室空间和设备购买、维护和共享成本 升级，行为核心使用和培训的代金券计划，以及支持核心董事的专注努力。是这样的 支持将促进保持高质量服务所需的行为核心资源的增长和扩展 目前受到当前用户的赞赏。行为核心总监与邻近的科布雷和 INBRE支持缅因州医学研究所和沙漠山生物研究所的研究中心 与其他区域研究中心协调行为核心服务的实验室。这种协调将使 在为长期可持续性做准备时，Behavior Core将扩大其用户基础。

The Behavior Core is built on a strong foundation of expertise in the fields of rodent sensory testing, pharmacological and optogenetic manipulation of neurons, preclinical early-stage drug discovery and development, and genotyping and colony management. The BC has become a critical resource for both COBRE and non-COBRE-affiliated investigators at the University of New England (UNE), regional and national academic users, and industry partners. Across Phase 3, the Core will continue to build on this diverse user base to create a stable and reliable revenue stream with the goal of becoming a sustainable resource for users requiring high quality in vivo testing. The BC will continue to provide (a) a centralized space for many behavioral assays and surgical procedures; (b) standardized protocols and training between laboratories to reduce variability and increase reproducibility and validity of behavioral assays; (c) advanced training and model development and validation (e.g., alternatives to reflexive nociceptive responses such as affective, cognitive, and pain- suppressed readouts). New developments include expanded space and equipment for independent testing areas for rats and mice to increase throughput and diminish potential confounds of testing both species in the same areas, expanded breeding and genotyping services to support the increased utilization of genetically-modified mouse and rat models, and support for investigators’ utilization of optogenetic approaches in behavioral studies. Continued training of Core research staff will be provided to ensure that the highest level of innovation and support can be provided to Behavior Core users. User feedback from internal and external users has consistently been highly positive. Core personnel have been included as authors on publications and Behavior Core services have been included in NIH grant submissions. Continued investments in its capabilities will allow the Core to provide the latest experimental tools in animal research and help the Core transition to fiscal independence. Noting the value that the COBRE research cores bring to UNE, the institution has outlined a commitment to support the Behavior Core for at least 5 years beyond the end of the Phase 3 funding period. Institutional commitments include dedicated laboratory space and shared costs for equipment purchase, maintenance, and upgrades, a voucher program for Behavior Core use and training, and support of dedicated effort for Core Directors. Such support will foster the growth and expansion of Behavior Core resources required to maintain the high-quality services currently appreciated by current users. The Behavior Core Director has worked closely with neighboring COBRE and INBRE supported research cores at the Maine Medical Research Institute and the Mount Desert Island Biological Laboratory to coordinate Behavior Core services with other regional research cores. This coordination will allow the Behavior Core to broaden its user base as it prepares for long-term sustainability.