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Sexual dimorphic circuits in photoperiodic encoding and photic processing

光周期编码和光处理中的性二态电路

基本信息

批准号：
10630931
负责人：
Jennifer Anne Evans
金额：
$ 40.59万
依托单位：
MARQUETTE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10630931
关键词：
Acceleration Acute Affect American Area Arrhythmia Attention Automobile Driving Behavior Biological Testing Brain Cells Chlorides Computer Analysis Data Desire for food Disease Down-Regulation Exclusion Female Foundations Health Jet Lag Syndrome Justice Light Link Mediating Metabolism Moods Mus Nervous System Physiology Neurophysiology - biologic function Pathology Pathway interactions Personal Satisfaction Persons Photoperiod Physiological Physiology Process Property Recovery Relapse Reporter Research Retina Retinal Ganglion Cells Risk Seasons Sex Differences Signal Transduction Sleep Stimulus Structure Test Result Testing Time Woman Work behavioral response biological sex cell type cellular imaging circadian combat day length gamma-Aminobutyric Acid gender disparity immune function insight male men molecular clock neural circuit neuroadaptation neurobiological mechanism neuromechanism novel optogenetics photoperiodicity response segregation sex sexual dimorphism shift work suprachiasmatic nucleus symporter

项目摘要

PROJECT SUMMARY/ABSTRACT Light regulates neurological function through circuits that remain poorly defined, and there remains a significant unmet need in understanding photic plasticity in the brain of both sexes. For example, seasonal changes in day length (i.e., photoperiod) modulate sleep, attention, appetite, metabolism, mood, and immune function occur in a large number of people, with up to 80% being women. The suprachiasmatic nucleus (SCN) drives circadian and photoperiodic responses to light, but there is a large gap in our understanding of sex differences in SCN photic and photoperiodic processing. Our preliminary data indicate that circadian and photoperiodic responses differ by sex, with females display larger behavioral responses to light mediated by divergent SCN circuits. Based on these data, we propose the central hypothesis that photic processing differs between males and females because the retina-SCN circuit is sexual dimorphic. We will test that biological sex influences cellular responses to light (Aim1), photoperiodic responses to day length (Aim2), and neural adaptations in SCN circuits (Aim3). These studies will benefit from the collective expertise of this collaborative research team, which specializes in retinal physiology, SCN network properties, cellular imaging, and computational analyses. Independent of sex differences, successful completion of these studies will provide novel insights into neural mechanisms of photic processing and photoperiodic encoding to advance understanding in both sexes. Further, this work is expected to provide information that will be critical to better understanding diseases incurred by other forms of light-induced disruption (e.g., shiftwork, jetlag).

项目总结/文摘