Sexual dimorphic circuits in photoperiodic encoding and photic processing
光周期编码和光处理中的性二态电路
基本信息
- 批准号:10630931
- 负责人:
- 金额:$ 40.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAcuteAffectAmericanAreaArrhythmiaAttentionAutomobile DrivingBehaviorBiological TestingBrainCellsChloridesComputer AnalysisDataDesire for foodDiseaseDown-RegulationExclusionFemaleFoundationsHealthJet Lag SyndromeJusticeLightLinkMediatingMetabolismMoodsMusNervous System PhysiologyNeurophysiology - biologic functionPathologyPathway interactionsPersonal SatisfactionPersonsPhotoperiodPhysiologicalPhysiologyProcessPropertyRecoveryRelapseReporterResearchRetinaRetinal Ganglion CellsRiskSeasonsSex DifferencesSignal TransductionSleepStimulusStructureTest ResultTestingTimeWomanWorkbehavioral responsebiological sexcell typecellular imagingcircadiancombatday lengthgamma-Aminobutyric Acidgender disparityimmune functioninsightmalemenmolecular clockneural circuitneuroadaptationneurobiological mechanismneuromechanismnoveloptogeneticsphotoperiodicityresponsesegregationsexsexual dimorphismshift worksuprachiasmatic nucleussymporter
项目摘要
PROJECT SUMMARY/ABSTRACT
Light regulates neurological function through circuits that remain poorly defined, and there remains a significant
unmet need in understanding photic plasticity in the brain of both sexes. For example, seasonal changes in
day length (i.e., photoperiod) modulate sleep, attention, appetite, metabolism, mood, and immune function
occur in a large number of people, with up to 80% being women. The suprachiasmatic nucleus (SCN) drives
circadian and photoperiodic responses to light, but there is a large gap in our understanding of sex differences
in SCN photic and photoperiodic processing. Our preliminary data indicate that circadian and photoperiodic
responses differ by sex, with females display larger behavioral responses to light mediated by divergent SCN
circuits. Based on these data, we propose the central hypothesis that photic processing differs between males
and females because the retina-SCN circuit is sexual dimorphic. We will test that biological sex influences
cellular responses to light (Aim1), photoperiodic responses to day length (Aim2), and neural adaptations in
SCN circuits (Aim3). These studies will benefit from the collective expertise of this collaborative research team,
which specializes in retinal physiology, SCN network properties, cellular imaging, and computational analyses.
Independent of sex differences, successful completion of these studies will provide novel insights into neural
mechanisms of photic processing and photoperiodic encoding to advance understanding in both sexes.
Further, this work is expected to provide information that will be critical to better understanding diseases
incurred by other forms of light-induced disruption (e.g., shiftwork, jetlag).
项目总结/摘要
光通过仍然不明确的回路调节神经功能,并且仍然存在显著的
在理解两性大脑的光可塑性方面尚未满足的需求。例如,
日长(即,光周期)调节睡眠、注意力、食欲、新陈代谢、情绪和免疫功能
发生在很多人身上,高达80%的人是女性。视交叉上核(SCN)
昼夜节律和光周期对光的反应,但我们对性别差异的理解存在很大差距
在SCN光和光周期处理中。我们的初步数据表明,昼夜节律和光周期
反应因性别而异,女性对由发散SCN介导的光表现出更大的行为反应
电路.基于这些数据,我们提出了一个中心假设,即光处理在男性之间是不同的
和女性,因为视网膜-SCN电路是两性异形的。我们将测试生物性别对
细胞对光的反应(Aim 1),光周期反应(Aim 2)和神经适应,
SCN电路(Aim 3)。这些研究将受益于这个合作研究小组的集体专业知识,
其专长于视网膜生理学、SCN网络特性、细胞成像和计算分析。
独立于性别差异,这些研究的成功完成将为神经系统疾病提供新的见解。
光处理和光周期编码的机制,以促进两性的理解。
此外,这项工作预计将提供信息,将是至关重要的,以更好地了解疾病
由其它形式的光诱导破坏引起(例如,轮班工作、时差)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jennifer Anne Evans其他文献
Jennifer Anne Evans的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Jennifer Anne Evans', 18)}}的其他基金
Sexual dimorphic circuits in photoperiodic encoding and photic processing
光周期编码和光处理中的性二态电路
- 批准号:
10453950 - 财政年份:2022
- 资助金额:
$ 40.59万 - 项目类别:
Inhibitory feedback mechanisms that couple circadian clock neurons in mammals
耦合哺乳动物生物钟神经元的抑制反馈机制
- 批准号:
9278316 - 财政年份:2015
- 资助金额:
$ 40.59万 - 项目类别:
Investigating circadian communication within the brain and body
研究大脑和身体内的昼夜节律交流
- 批准号:
8278631 - 财政年份:2010
- 资助金额:
$ 40.59万 - 项目类别:
Investigating circadian communication within the brain and body
研究大脑和身体内的昼夜节律交流
- 批准号:
8118518 - 财政年份:2010
- 资助金额:
$ 40.59万 - 项目类别:
Investigating circadian communication within the brain and body
研究大脑和身体内的昼夜节律交流
- 批准号:
8003480 - 财政年份:2010
- 资助金额:
$ 40.59万 - 项目类别:
相似海外基金
Transcriptional assessment of haematopoietic differentiation to risk-stratify acute lymphoblastic leukaemia
造血分化的转录评估对急性淋巴细胞白血病的风险分层
- 批准号:
MR/Y009568/1 - 财政年份:2024
- 资助金额:
$ 40.59万 - 项目类别:
Fellowship
Combining two unique AI platforms for the discovery of novel genetic therapeutic targets & preclinical validation of synthetic biomolecules to treat Acute myeloid leukaemia (AML).
结合两个独特的人工智能平台来发现新的基因治疗靶点
- 批准号:
10090332 - 财政年份:2024
- 资助金额:
$ 40.59万 - 项目类别:
Collaborative R&D
Acute senescence: a novel host defence counteracting typhoidal Salmonella
急性衰老:对抗伤寒沙门氏菌的新型宿主防御
- 批准号:
MR/X02329X/1 - 财政年份:2024
- 资助金额:
$ 40.59万 - 项目类别:
Fellowship
Cellular Neuroinflammation in Acute Brain Injury
急性脑损伤中的细胞神经炎症
- 批准号:
MR/X021882/1 - 财政年份:2024
- 资助金额:
$ 40.59万 - 项目类别:
Research Grant
KAT2A PROTACs targetting the differentiation of blasts and leukemic stem cells for the treatment of Acute Myeloid Leukaemia
KAT2A PROTAC 靶向原始细胞和白血病干细胞的分化,用于治疗急性髓系白血病
- 批准号:
MR/X029557/1 - 财政年份:2024
- 资助金额:
$ 40.59万 - 项目类别:
Research Grant
Combining Mechanistic Modelling with Machine Learning for Diagnosis of Acute Respiratory Distress Syndrome
机械建模与机器学习相结合诊断急性呼吸窘迫综合征
- 批准号:
EP/Y003527/1 - 财政年份:2024
- 资助金额:
$ 40.59万 - 项目类别:
Research Grant
FITEAML: Functional Interrogation of Transposable Elements in Acute Myeloid Leukaemia
FITEAML:急性髓系白血病转座元件的功能研究
- 批准号:
EP/Y030338/1 - 财政年份:2024
- 资助金额:
$ 40.59万 - 项目类别:
Research Grant
STTR Phase I: Non-invasive focused ultrasound treatment to modulate the immune system for acute and chronic kidney rejection
STTR 第一期:非侵入性聚焦超声治疗调节免疫系统以治疗急性和慢性肾排斥
- 批准号:
2312694 - 财政年份:2024
- 资助金额:
$ 40.59万 - 项目类别:
Standard Grant
ロボット支援肝切除術は真に低侵襲なのか?acute phaseに着目して
机器人辅助肝切除术真的是微创吗?
- 批准号:
24K19395 - 财政年份:2024
- 资助金额:
$ 40.59万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Acute human gingivitis systems biology
人类急性牙龈炎系统生物学
- 批准号:
484000 - 财政年份:2023
- 资助金额:
$ 40.59万 - 项目类别:
Operating Grants