Environmental Carcinogenesis and Mutagenesis

本申请书旨在续期T32 ES-09250-30培训补助金，题为“环境致癌和 突变“(ECM)，自1986年创立以来一直在斯坦布鲁克博士的指导下。阿尔瓦罗博士 Puga，Co-Pi，从该项目的历史早期起就是该项目的导师，并担任助理 在过去五年预算期间，他将继续担任主任一职。ECM培训计划最初 正如其标题所暗示的那样，专门专注于环境致癌和诱变。随后， 计划已经在科学和概念上得到了发展。当NIEHS指示时，它增长到目前的最佳大小 它与一个较小的毒理学培训项目合并。该计划在科学上变得更加多样化， 对实习生来说是无价的。ECM计划尽一切努力保持这一学科的广度 加强学员之间思想和技术的交流。因此，受训人员能够 从遗传学、细胞生物学和毒理学的角度有力地讨论环境暴露的影响 最终是在包括癌症在内的人类疾病的背景下。为了保持这种广泛的学科范围， 该计划拥有26名参与教职员工，他们来自12个不同的系/科 辛辛那提大学医学院(UCCOM)或辛辛那提儿童医院医学中心 (CCHMC)。这两间学院的教职员之间有非常密切的工作关系，而 CCHMC的所有教职员工都在UCCOM预约了儿科。对ECM承诺的财政支持 来自这两个机构的招聘和其他与培训有关的费用就是这种紧密关系的例证 以及对ECM的支持。ECM继续在过去的成功基础上再接再厉，毕业生人数不断增加 学术、监管和行业领导职位。它还继续满足国家对培训的需求 与生物、肿瘤和毒物终点有关的环境暴露影响中的个人 和人类疾病。自成立以来，该方案一直强调招聘任职人数不足的人。 少数群体，并在这一努力中取得成功。从制度上讲，该计划将研究集中在一起 几个实验室努力提供对暴露和环境健康的共同关注，并促进 这些实验室之间的合作。ECM鼓励受训者从事结合了 几个实验室和机构研究中心的专业知识。我们的两周一次的会议，实习生 或者，提供他们自己的数据或一篇专题论文来加强这些互动。博士前实习生都有 相当于化学、生物或物理科学的本科专业，具有卓越的学术成就 成就。许多人在参加该计划时获得了奖项和认可。我们挑选博士后候选人 根据已证实的学术成就，拥有博士、医学博士或医学博士学位的人，以及 博士前研究员，我们从全国申请者库中挑选实习生。此续订申请要求8个 博士后和四个博士后职位，我们认为这个规模最适合这个项目的使命和目标。

This application is to renew the T32 ES-09250-30 training grant entitled, “Environmental Carcinogenesis and Mutagenesis” (ECM) which has been under the direction of Dr. Stambrook since its inception in 1986. Dr. Alvaro Puga, the Co-PI, has been a mentor in the Program since early in its history and has served as Associate Director for the past five-year budget period, a role in which he will continue. The ECM training program initially focused exclusively on environmental carcinogenesis and mutagenesis as its title implied. Subsequently, the Program has evolved scientifically and conceptually. It grew to its current optimal size when the NIEHS directed that it merge with a smaller training program in toxicology. The Program became scientifically more diverse which has proven invaluable to the trainees. The ECM program makes every effort to retain this breadth of disciplines to enhance cross-fertilization of ideas and techniques between the trainees. Thus, the trainees are able to discuss cogently the impact of environmental exposures in terms of genetics, cell biology and toxicology and ultimately in the context of human disease, including cancer. To preserve this wide range of disciplines, the Program maintains a participating faculty of 26 who derive from 12 different departments/divisions from the University of Cincinnati College of Medicine (UCCOM) or the Cincinnati Children's Hospital Medical Center (CCHMC). There is a very close working relationship between the faculty of these two institutions, and the CCHMC faculty all have appointments in pediatrics at UCCOM. The financial support committed to the ECM from both institutions for recruitment and for other training-related expenses exemplifies this tight relationship and support for the ECM. The ECM continues to build on its past successes, with its graduates populating academic, regulatory and industry leadership positions. It also continues to fulfill a national need to train individuals in the impact of environmental exposure relating to biological, oncological and toxicological endpoints and human disease. Since its inception, the Program has emphasized recruitment of under-represented minorities, and has been successful in this endeavor. Institutionally, the Program brings together the research efforts of several laboratories to provide a common focus on exposure and environmental health, and facilitates collaborations between these laboratories. The ECM encourages trainees to engage in research that combines the expertise of several laboratories and institutional research cores. Our biweekly meetings where trainees alternatively present their own data or a topical paper reinforce these interactions. Pre-doctoral trainees all have the equivalent of an undergraduate major in a chemical, biological or physical science with superior academic achievements. Many have won awards and recognition while in the Program. We select postdoctoral candidates who hold the degrees of Ph.D., D.V.M. or M.D., based on proven academic accomplishments, and like predoctoral fellows, we select trainees from a national pool of applicants. This renewal application requests eight pre-doctoral and four postdoctoral positions, a size that we find optimal for the mission and goals of this Program.