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Animal Core

动物核心

基本信息

批准号：
10629169
负责人：
ROBERT A KESTERSON
金额：
$ 21.46万
依托单位：
LSU PENNINGTON BIOMEDICAL RESEARCH CTR
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-07-01 至 2026-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10629169
关键词：
Address Animal Model Animals Area Behavior Body Composition CRISPR/Cas technology Categories Comparative Biology Consultations DNA Data Analyses Energy Metabolism Environment Equipment Experimental Designs Faculty Feeding behaviors Funding Future Gene Expression Gene Targeting Generations Genes Goals Grant Health Human Infrastructure Knock-in Knockout Mice Longevity Louisiana Metabolic Metabolic Diseases Metabolism Methods Mission Molecular Monitor Mus National Institute of Diabetes and Digestive and Kidney Diseases Nutritional Study Obesity Operative Surgical Procedures Phase Phenotype Physical Endurance Physical activity Rattus Research Research Personnel Research Project Grants Rodent Rodent Model Scientist Services Techniques Technology Tissues Training Transgenic Organisms Translational Research United States National Institutes of Health Viral Vector Work behavioral phenotyping experimental study flexibility genetic manipulation human disease in vivo innovation knockout gene member metabolic phenotype nutrition obesogenic programs promoter protocol development success

项目摘要

PROJECT SUMMARY / ABSTRACT (ANIMAL MODELS & PHENOTYPING CORE) The Animal Models and Phenotyping Core (AMPC) supports animal-based studies across the NORC theme of “Nutrition, Obesity and Metabolic Health through the Lifespan”. These services focus on two primary areas: 1) the controlled manipulation of gene expression in rodents, and 2) provide state-of-the-art in vivo metabolic and behavioral phenotyping. Over past funding cycles, the AMPC has been a key component of the overall mission of the Pennington/Louisiana NORC, enhancing and facilitating funded research while also stimulating new and innovative research related to nutrition and obesity. The AMPC is essential for a broad range of research within the NORC, supporting more than 36 NIDDK and other NIH grants in the past cycle while also interacting closely with the Administrative Core, Molecular Mechanisms Core, and the Human Phenotyping Core to assure success in achieving the Specific Aims of each research project. This critical support will be sustained in the current cycle by: A) continuing to utilize transgenic and gene targeting techniques to generate rodent models that mimic human metabolic disease states; B) using state of the art equipment and technology to conduct detailed in vivo metabolic and behavioral phenotyping, and; C) providing consultation related to rodent nutrition and obesity research, training in the use of experimental services, and pursuing new methods and experimental paradigms that anticipate the needs of NORC members and Pilot and Feasibility projects. Through these goals, the AMPC will directly support the use of animal models to better understand human disease states in a translational research approach while also facilitating cross-talk among scientists focused on nutrition and obesity research.

项目摘要/摘要（动物模型和表型核心）