Daily personal light exposure patterns and sleep in emergency department healthcare workers (administrative supplement to R01 HL146911)

项目总结/摘要 光是影响人类昼夜节律系统的最强生物信号，进而影响睡眠。 在白天暴露于足够高水平的光，结合在白天的昏暗光/黑暗， 晚上和晚上，是必要的，以保持强大的和适当的时间昼夜节律的生理 和神经内分泌，促进充足的睡眠。相反，减少光 整个白天的曝光水平和在“错误时间”出现的增加的曝光（例如，的 生物夜晚）可通过引起昼夜节律失调，扰乱褪黑激素分泌， 增加神经认知唤醒、延迟睡眠开始和恶化睡眠质量。光 环境及其对睡眠的影响是重要的考虑，因为睡眠影响几乎所有方面， 身体和精神健康和疾病，以及日常功能和表现。因此，个人光 暴露代表影响关键健康行为（睡眠）的重要的可延展的背景因素。 在一项正在进行的前瞻性3年观察性队列研究（R 01 HL 146911，MPI：Chang/Shechter; “改善研究”），我们正在评估环境压力源和睡眠干扰对 急诊科（艾德）医护人员（HCW）的心血管和心理风险。一个 IMPROVE研究的首要目标是客观地评估以下方面的短期和长期贡献： 估计睡眠时间短和睡眠质量差，血压发生急性和进行性变化， 心理风险（例如，burnout）。在当前的行政补充中，我们将利用基础设施 的IMPROVE研究，通过一项 小型可穿戴微型分光光度计（光针），用于参加父组的参与者子集 改善学习。这部分参与者将在他们预定的年度2- 在自由生活条件下连续跟踪睡眠的每周数据突发。的目的 行政补充是为了确定曝光模式和我们的主要关系 心血管和心理风险的行为预测因子-睡眠。研究个人暴露在阳光下 与睡眠相关的模式将提供关于该因素在影响睡眠中的机械作用的信息。这 这项工作可以为开发新的行为干预提供信息， 改善睡眠和下游健康相关结果的模式。

PROJECT SUMMARY / ABSTRACT Light is the strongest biological signal influencing the human circadian system, and by extension, sleep. Exposure to light of sufficiently high levels during the daytime, combined with dim light/darkness during the evening and night, is necessary to maintain robust and appropriately timed circadian rhythms in physiology and neuroendocrine secretion, and to promote good sleep of sufficient duration. Conversely, reduced light exposure levels throughout the daytime and increased light exposure occurring at the “wrong time” (e.g., the biological night) can disturb sleep by causing circadian misalignment, disrupting melatonin secretion, increasing neurocognitive arousal, delaying sleep initiation, and worsening sleep quality. The light environment and its impact on sleep is important to consider because sleep influences nearly all aspects of physical and mental health and disease, as well as daily function and performance. Thus, personal light exposure represents an important malleable contextual factor that influences a critical health behavior (sleep). In an ongoing prospective 3-year observational cohort study (R01HL146911, MPI: Chang/Shechter; “IMPROVE Study”), we are evaluating the impact of environmental stressors and disturbed sleep on cardiovascular and psychological risk in emergency department (ED) healthcare workers (HCWs). An overarching goal of the IMPROVE Study is to evaluate the short- and long-term contribution of objectively- estimated short sleep duration and poor quality sleep to acute and progressive changes in blood pressure and psychological risk (e.g., burnout). In the current administrative supplement, we will leverage the infrastructure of the ongoing IMPROVE Study to add on an objective assessment of personal light exposure patterns via a small wearable mini-spectrophotometer (light pin) in a subset of participants who are enrolled in the parent IMPROVE study. This subset of participants will wear the light pin during one of their scheduled annual 2- week data bursts in which sleep is continuously tracked under free-living conditions. The aim of the administrative supplement is to determine the relationship between light exposure patterns and our main behavioral predictor of cardiovascular and psychological risk—sleep. Examining how personal light exposure patterns relate to sleep will provide information on the mechanistic role of this factor in influencing sleep. This work can inform the development of novel behavioral interventions focusing on personal light exposure patterns to improve sleep and downstream health-related outcomes.