Daily personal light exposure patterns and sleep in emergency department healthcare workers (administrative supplement to R01 HL146911)

项目摘要/摘要 光是影响人类昼夜节律系统的最强生物信号，进而影响睡眠。 白天暴露在足够高的光线下，加上白天的暗光/黑暗 傍晚和夜间，是维持生理学上强健和适当时机的昼夜节律所必需的 和神经内分泌，并促进充足时间的良好睡眠。反之，光线减少 白天的暴露量和在“错误的时间”发生的光暴露量的增加(例如 生物夜)会导致昼夜节律失调，扰乱褪黑激素的分泌， 增加神经认知唤醒，延迟睡眠开始，并恶化睡眠质量。那盏灯 环境及其对睡眠的影响是值得考虑的，因为睡眠几乎影响到 身心健康和疾病，以及日常功能和表现。因此，个人之光 暴露是影响关键健康行为(睡眠)的一个重要的可塑性背景因素。 在一项正在进行的3年前瞻性观察队列研究中(R01HL146911，MPI：Chang/Shechter； “改善研究”)，我们正在评估环境应激源和睡眠障碍对 急诊科医护人员的心血管和心理风险。一个 改进研究的总体目标是客观地评估以下各项的短期和长期贡献： 估计睡眠时间短和睡眠质量差与血压和血压的急性渐进性变化有关 心理风险(例如，职业倦怠)。在当前的行政补充中，我们将利用基础设施 正在进行的改进研究增加了对个人光照模式的客观评估 在家长中登记的参与者子集中的小型可穿戴迷你分光光度计(光针) 加强学习。这一小组的参与者将在他们预定的年度2-2次会议中佩戴灯针- 在自由生活条件下连续跟踪睡眠的一周数据突发。该计划的目的是 行政辅助是确定曝光图案与我们的次要关系 心血管和心理风险的行为预测因子--睡眠。研究个人光暴露如何 与睡眠相关的模式将提供关于这一因素在影响睡眠中的机械作用的信息。这 工作可以为关注个人光暴露的新型行为干预的发展提供信息 改善睡眠和下游健康相关结果的模式。

PROJECT SUMMARY / ABSTRACT Light is the strongest biological signal influencing the human circadian system, and by extension, sleep. Exposure to light of sufficiently high levels during the daytime, combined with dim light/darkness during the evening and night, is necessary to maintain robust and appropriately timed circadian rhythms in physiology and neuroendocrine secretion, and to promote good sleep of sufficient duration. Conversely, reduced light exposure levels throughout the daytime and increased light exposure occurring at the “wrong time” (e.g., the biological night) can disturb sleep by causing circadian misalignment, disrupting melatonin secretion, increasing neurocognitive arousal, delaying sleep initiation, and worsening sleep quality. The light environment and its impact on sleep is important to consider because sleep influences nearly all aspects of physical and mental health and disease, as well as daily function and performance. Thus, personal light exposure represents an important malleable contextual factor that influences a critical health behavior (sleep). In an ongoing prospective 3-year observational cohort study (R01HL146911, MPI: Chang/Shechter; “IMPROVE Study”), we are evaluating the impact of environmental stressors and disturbed sleep on cardiovascular and psychological risk in emergency department (ED) healthcare workers (HCWs). An overarching goal of the IMPROVE Study is to evaluate the short- and long-term contribution of objectively- estimated short sleep duration and poor quality sleep to acute and progressive changes in blood pressure and psychological risk (e.g., burnout). In the current administrative supplement, we will leverage the infrastructure of the ongoing IMPROVE Study to add on an objective assessment of personal light exposure patterns via a small wearable mini-spectrophotometer (light pin) in a subset of participants who are enrolled in the parent IMPROVE study. This subset of participants will wear the light pin during one of their scheduled annual 2- week data bursts in which sleep is continuously tracked under free-living conditions. The aim of the administrative supplement is to determine the relationship between light exposure patterns and our main behavioral predictor of cardiovascular and psychological risk—sleep. Examining how personal light exposure patterns relate to sleep will provide information on the mechanistic role of this factor in influencing sleep. This work can inform the development of novel behavioral interventions focusing on personal light exposure patterns to improve sleep and downstream health-related outcomes.