Functional and computational characterization of the human auditory cortex
人类听觉皮层的功能和计算特征
基本信息
- 批准号:10668380
- 负责人:
- 金额:$ 52.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-04-01 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AcousticsAddressAnatomyAnimal ModelAphasiaAreaAuditory PerceptionAuditory areaBrainCategoriesCharacteristicsCommunication impairmentComprehensionComputer ModelsDimensionsDisciplineDyslexiaElectrocorticogramElectroencephalographyElectrophysiology (science)FrequenciesHealthHumanImpairmentImplanted ElectrodesIntuitionJointsKnowledgeLanguage DevelopmentLanguage DisordersLinear RegressionsLinguisticsMapsMeasurementMeasuresMethodologyMethodsModelingNational Institute on Deafness and Other Communication DisordersNatureNeural Network SimulationNeurobiologyPatientsPersonsPhoneticsProcessPropertyProsthesisRegional AnatomyResearchResolutionResponse LatenciesSemanticsSignal TransductionSiteSpecific qualifier valueSpecificitySpeechSpeech AcousticsSpeech DisordersSpeech PathologySpeech PerceptionStimulusSuperior temporal gyrusSurfaceTechnologyTimeTrainingUnited StatesWorkauditory processingauditory stimulusconvolutional neural networkcortex mappingimprovedinnovationinsightinterestlinear transformationneuralneural circuitneural networkneurophysiologyneurosurgeryneurotransmissionnonhuman primatenovelphonologypredicting responsereceptive fieldresponsesoundspeech processingtemporal measurement
项目摘要
According to NIDCD, 6 to 8 million people in the United States have some form of speech or communication
disorder. Speech perception requires a listener to map variable acoustic signals onto a finite set of phonological
categories known as phonemes, and to integrate those categories over time to form larger linguistic units such
as syllables and words. It remains speculative where these different speech features are encoded and what
cortical computations are needed for their calculation from an acoustic signal. A better understanding of what
neural circuits are involved, how they are organized, and what computations they perform to support speech
comprehension is critical for developing a detailed neurobiological model of speech perception. The major aim
of this proposal is to use a joint framework to study the encoding of acoustic and linguistic features and the
computational underpinnings of natural speech processing, using invasive surface and depth electrodes
implanted in human neurosurgical patients. To study the cortical organization of acoustic features, we will
characterize the encoding and anatomical organization of acoustic features in auditory cortical regions. To study
the cortical organization of linguistic features, we will measure the encoding of phonetic, phonotactic, and
semantic information using multivariate linear regression. To understand the underlying computational
mechanisms, we will train convolutional neural network models to predict the neural responses to speech and
use a novel method to express their computation as a set of linear transforms. By interpreting these models, we
will uncover nonlinear computations used in different auditory areas and relate them to the encoding of acoustic
and linguistic features. These complementary analyses will extend our knowledge of speech processing in the
human auditory cortex and lead to new hypotheses about the mechanisms of various speech and language
disorders. Together, the proposed research will greatly improve the current models of cortical speech processing,
which are of great interest in many disciplines including neurolinguistics, speech pathology, speech prostheses,
and speech technologies.
根据NIDCD的数据,美国有600万到800万人有某种形式的语言或交流
项目成果
期刊论文数量(25)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
SYNAPTIC DEPRESSION IN DEEP NEURAL NETWORKS FOR SPEECH PROCESSING.
- DOI:10.1109/icassp.2016.7472802
- 发表时间:2016-03
- 期刊:
- 影响因子:0
- 作者:Zhang W;Li H;Yang M;Mesgarani N
- 通讯作者:Mesgarani N
Joint Representation of Spatial and Phonetic Features in the Human Core Auditory Cortex.
人类核心听觉皮层空间和语音特征的联合表示。
- DOI:10.1016/j.celrep.2018.07.076
- 发表时间:2018
- 期刊:
- 影响因子:8.8
- 作者:Patel,Prachi;Long,LauraK;Herrero,JoseL;Mehta,AsheshD;Mesgarani,Nima
- 通讯作者:Mesgarani,Nima
Automatic speaker diarization for natural conversation analysis in autism clinical trials.
- DOI:10.1038/s41598-023-36701-4
- 发表时间:2023-06-24
- 期刊:
- 影响因子:4.6
- 作者:
- 通讯作者:
Predictive Ensemble Decoding of Acoustical Features Explains Context-Dependent Receptive Fields.
- DOI:10.1523/jneurosci.4648-15.2016
- 发表时间:2016-12-07
- 期刊:
- 影响因子:0
- 作者:Yildiz IB;Mesgarani N;Deneve S
- 通讯作者:Deneve S
Functional characterization of human Heschl's gyrus in response to natural speech.
- DOI:10.1016/j.neuroimage.2021.118003
- 发表时间:2021-07-15
- 期刊:
- 影响因子:5.7
- 作者:Khalighinejad B;Patel P;Herrero JL;Bickel S;Mehta AD;Mesgarani N
- 通讯作者:Mesgarani N
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Nima MESGARANI其他文献
Nima MESGARANI的其他文献
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{{ truncateString('Nima MESGARANI', 18)}}的其他基金
Functional and computational characterization of the human auditory cortex
人类听觉皮层的功能和计算特征
- 批准号:
10473651 - 财政年份:2015
- 资助金额:
$ 52.52万 - 项目类别:
Neurophysiology of robust speech perception in human superior temporal gyrus
人类颞上回稳健言语感知的神经生理学
- 批准号:
9231432 - 财政年份:2015
- 资助金额:
$ 52.52万 - 项目类别:
Functional and computational characterization of the human auditory cortex
人类听觉皮层的功能和计算特征
- 批准号:
10225600 - 财政年份:2015
- 资助金额:
$ 52.52万 - 项目类别:
Functional and computational characterization of the human auditory cortex
人类听觉皮层的功能和计算特征
- 批准号:
9973774 - 财政年份:2015
- 资助金额:
$ 52.52万 - 项目类别:
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