Functional characterization of human Heschl's gyrus in response to natural speech.

Functional characterization of human Heschl's gyrus in response to natural speech.
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DOI:
10.1016/j.neuroimage.2021.118003
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发表时间:
2021-07-15
期刊:
影响因子:
5.7
通讯作者:
Mesgarani N
Mesgarani N
中科院分区:
医学1区
文献类型:
--
作者:
Khalighinejad B;Patel P;Herrero JL;Bickel S;Mehta AD;Mesgarani N

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颞下丘脑回(HG)是一个包括人类初级听觉皮层的大脑区域。由于在自然语音听力中对该区域的直接神经测量的限制,HG在语音感知中的功能组织和作用仍然不确定。在这里,我们使用颅内脑电图直接记录8名神经外科患者在听连续的言语故事时HG的神经活动。我们研究了声学调谐的空间分布和语言特征编码的组织。我们发现HG的主要变化梯度是从后内侧到前外侧。我们还观察到频率和时间调制调谐的减少,音位表征、说话人规范化、语音灵敏度和响应延迟的增加。我们没有观察到两个大脑半球之间的差异。这些发现揭示了HG在处理和转化简单到复杂的声学特征中的功能作用,并为人类听觉皮层语音处理的神经生理模型提供了信息。
Heschl’s gyrus (HG) is a brain area that includes the primary auditory cortex in humans. Due to the limitations in obtaining direct neural measurements from this region during naturalistic speech listening, the functional organization and the role of HG in speech perception remain uncertain. Here, we used intracranial EEG to directly record neural activity in HG in eight neurosurgical patients as they listened to continuous speech stories. We studied the spatial distribution of acoustic tuning and the organization of linguistic feature encoding. We found a main gradient of change from posteromedial to anterolateral parts of HG. We also observed a decrease in frequency and temporal modulation tuning and an increase in phonemic representation, speaker normalization, speech sensitivity, and response latency. We did not observe a difference between the two brain hemispheres. These findings reveal a functional role for HG in processing and transforming simple to complex acoustic features and inform neurophysiological models of speech processing in the human auditory cortex.
细胞外田地和电流的起源-EEG,ECOG,LFP和尖峰。
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