Multidisciplinary Training in Microbial Pathogenesis

微生物发病机制的多学科培训

• 批准号: 10667488
• 负责人: Patricia Jean Johnson
• 金额: $ 40.51万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667488
• 关键词: Pathogenesis; Training; microbial; multidisciplinary

PROJECT SUMMARY ABSTRACT The UCLA Microbial Pathogenesis Training Grant (MPTG) provides the foundation for an integrated research training program in the biochemistry, cell biology & genetics of microbial pathogens and host-pathogen interactions. The program’s goal is to train scientists to conduct research in microbial pathogenesis using molecular, cellular, genetic, immunological, genomic, proteomic and “post-omic” approaches. Our training faculty includes 22 preceptors with a broad range of related research interests in the areas of bacteriology, parasitology, virology, and immunology. Faculty preceptors have excellent publication, funding and training records. The program was first funded in 1988 and is currently in its 29th year of funding. MPTG is small, with five predoctoral and two postdoctoral funded positions; yet it plays a vital role, not limited to trainees, in educating PhD students and postdoctoral fellows in the field of microbial pathogenesis at UCLA. Most of our predoctoral trainees are recruited through the Graduate Program in Biosciences (GPB) which provides an excellent pool of 92 predoctoral students on average yearly. For many years, >25% of entering PhD students express interests in microbiology, immunology and host:pathogen interactions. Our faculty are also highly successful in attracting qualified postdoctoral fellows, having a mean of 16 postdoctoral fellows eligible for support in any given year. Trainees are selected for funding on a competitive basis, after a thorough review of their academic and research accomplishments. Progress is reviewed throughout the year and appointments are competitively renewed yearly with a maximum of three years of support for predoctoral trainees and two years for postdoctoral trainees. The training program requires the completion of coursework focused on microbial pathogenesis, annual presentations of trainee research in symposia attended by all trainees and training preceptors, and participation in a Microbial Pathogenesis seminar series composed of external, preeminent scientists in the field & associated literature discussions. Trainees also participate in a journal club focused on host:pathogen interactions and newly emerging infectious agents. These journal clubs are jointly facilitated by training preceptors and trainees and serve to broaden trainee education. Participation in a course devoted to ethics and accountability in biomedical research and a scientific writing course is also required. All trainees are required to develop career objectives guided by “My Individual Development Plan (IDP)”. Postdoctoral trainees are also required to participate in the PhD Career Training Series and research-related career focused workshops. Career counseling by the program director and training grant advisory committee is also emphasized. Annual research presentations at national meetings and UCLA scientific retreats are expected. The focal point of our training program is excellence in research. Several mechanisms are in place to monitor and facilitate trainee progress in research and career development. Our past training efforts have been successful and continued success is anticipated following the plan described in this proposal.

项目摘要 加州大学洛杉矶分校微生物发病机制培训补助金（MPTG）为综合研究提供了基础 微生物病原体和宿主病原体的生物化学，细胞生物学和遗传学培训计划 交互.该计划的目标是培训科学家利用微生物致病机理进行研究 分子、细胞、遗传、免疫、基因组、蛋白质组和“后组学”方法。我们的培训 教师包括22名导师，他们在细菌学领域有广泛的相关研究兴趣， 寄生虫学病毒学和免疫学教师导师有优秀的出版物，资金和培训 记录该计划于1988年首次获得资助，目前已进入第29个资助年。MPTG很小， 五个博士前和两个博士后资助的职位;但它发挥着至关重要的作用，不仅限于学员， 在加州大学洛杉矶分校的微生物发病机理领域教育博士生和博士后研究员。我们的大多数 通过生物科学研究生课程（GPB）招募博士前学员，该课程提供 平均每年有92名优秀的博士生。多年来，>25%的进入博士生 对微生物学、免疫学和宿主与病原体的相互作用感兴趣。我们的教师也很高 成功地吸引了合格的博士后研究员，平均有16名博士后研究员符合条件， 支持任何一年。在全面审查下列因素之后，通过竞争挑选受训人员， 他们的学术和研究成就。全年审查进展情况， 每年竞争性更新，最多为博士前学员提供三年的支持， 年为博士后。培训计划要求完成课程，重点是 微生物发病机理，在所有受训人员参加的专题讨论会上每年介绍受训人员的研究， 培训导师，并参加由外部， 该领域的杰出科学家和相关文献讨论。学员还参加一个期刊俱乐部 重点是宿主：病原体的相互作用和新出现的感染因子。这些期刊俱乐部联合 通过培训导师和学员提供便利，并扩大学员教育。参加课程 致力于生物医学研究中的道德和责任，还需要一门科学写作课程。所有 学员须以“个人发展计划”为指引，制定职业目标。 博士后学员还需要参加博士职业培训系列和研究相关的 以职业为中心的研讨会。由项目主任和培训补助金咨询委员会提供的职业咨询是 也强调。在国家会议和加州大学洛杉矶分校科学务虚会上的年度研究报告是 预期我们的培训计划的重点是卓越的研究。若干机制已经到位 监督和促进受训人员在研究和职业发展方面的进展。我们过去的培训工作 在执行本提案所述计划后，预期将继续取得成功。

项目成果

Molecular dissection of novel trafficking and processing of the Toxoplasma gondii rhoptry metalloprotease toxolysin-1.

• DOI: 10.1111/j.1600-0854.2011.01308.x
• 发表时间: 2012-02
• 期刊: Traffic (Copenhagen, Denmark)
• 作者: Hajagos BE;Turetzky JM;Peng ED;Cheng SJ;Ryan CM;Souda P;Whitelegge JP;Lebrun M;Dubremetz JF;Bradley PJ
• 通讯作者: Bradley PJ

Strain-Level Differences in Porphyrin Production and Regulation in Propionibacterium acnes Elucidate Disease Associations.

• DOI: 10.1128/msphere.00023-15
• 发表时间: 2016-01
• 期刊: mSphere
• 影响因子: 4.8
• 作者: Johnson T;Kang D;Barnard E;Li H
• 通讯作者: Li H

Parasite extracellular vesicles: mediators of intercellular communication.

• DOI: 10.1371/journal.ppat.1004289
• 发表时间: 2014-08
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Twu O;Johnson PJ
• 通讯作者: Johnson PJ

Trichomonas vaginalis Macrophage Migration Inhibitory Factor Mediates Parasite Survival during Nutrient Stress.

• DOI: 10.1128/mbio.00910-18
• 发表时间: 2018-06-26
• 期刊: mBio
• 影响因子: 6.4
• 作者: Chen YP;Twu O;Johnson PJ
• 通讯作者: Johnson PJ

Evidence for ubiquitin-regulated nuclear and subnuclear trafficking among Paramyxovirinae matrix proteins.

• DOI: 10.1371/journal.ppat.1004739
• 发表时间: 2015-03
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Pentecost M;Vashisht AA;Lester T;Voros T;Beaty SM;Park A;Wang YE;Yun TE;Freiberg AN;Wohlschlegel JA;Lee B
• 通讯作者: Lee B