Training in Microbial Pathogenesis and Genomics

微生物发病机制和基因组学培训

• 批准号: 10080699
• 负责人: Mark D Goulian
• 金额: $ 25.26万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10080699
• 关键词: Genomics; Pathogenesis; Training; microbial

This application is a new submission for our Microbial Pathogenesis and Genomics training program, which was previously supported by a T32 from 2006-2016. We are requesting support for five predoctoral trainees per year. The program, which is based at the University of Pennsylvania and Children's Hospital of Philadelphia and is located on a single contiguous campus, includes twelve laboratories directed by well- established principle investigators and three "junior investigators", who are newly appointed assistant professors. Based on the success of the previously funded program, this T32 will enable us to continue to recruit some of the best and brightest trainees from a talented pool at Penn and from a vibrant biomedical environment that offers a large number of outstanding research opportunities for students. The organized training mission of this T32 has helped our efforts to collaborate and interact more effectively as a group; our trainers have several joint NIH grants, numerous joint publications, and a network of robust collaborations that involve our trainees. Our research in progress meetings and seminars within the microbiology program have helped spur the rapid growth of exciting, collaborative work in bacterial pathogenesis, microbial immunopathogenesis, and bacterial metagenomics, with institutional support for deep-sequencing facilities, bioinformatics, and a germ-free mouse core playing important roles in these efforts. These resources have been expanded to the new Penn-CHOP Microbiome Program, which will be a major focal point for new research and collaborations within our T32. The retention rate of our previously funded program was perfect; no trainee left the program prematurely over the 10 years of funding. In addition, all of our former trainees have continued to work in Microbiology or closely related fields involving infectious diseases. Five of our previous trainees have obtained tenure-track faculty positions – all at major universities. The research opportunities provided by the trainers in this program coupled with strong institutional commitment and an extensive and well-organized training program will continue to provide excellent predoctoral training in microbial pathogenesis and genomics.

此应用程序是我们的微生物发病机制和基因组学培训计划的新提交， 2006-2016年由T32支持。我们请求支援五名博士前实习生 每一年。该项目位于宾夕法尼亚大学和宾夕法尼亚州儿童医院。 费城，位于一个单一的连续校园，包括12个实验室，由良好的指导， 设立了主要调查员和三名“初级调查员”，后者是新任命的助理 教授们。基于先前资助计划的成功，T32将使我们能够继续 从宾夕法尼亚大学的人才库和充满活力的生物医学 为学生提供大量优秀研究机会的环境。有组织 这次T32的训练使命帮助了我们作为一个团队更有效地合作和互动;我们的 培训师拥有多项NIH联合赠款、众多联合出版物和一个强大的合作网络， 让我们的学员参与进来我们的研究进展会议和研讨会内的微生物学计划有 帮助刺激了细菌致病机理、微生物 免疫发病机制和细菌宏基因组学，以及对深度测序设施的机构支持， 生物信息学和无菌小鼠核心在这些努力中发挥重要作用。这些资源 已扩大到新的宾夕法尼亚州CHOP微生物组计划，这将是一个新的主要焦点 在我们的T32中进行研究和合作。我们以前资助的项目的留存率是完美的; 在10年的资助期间，没有受训人员过早离开该方案。另外，我们所有的前学员 继续在微生物学或与传染病密切相关的领域工作。我们五 以前的受训人员都获得了终身教职-都在主要大学。研究 培训师在该计划中提供的机会，加上强有力的机构承诺和 广泛和组织良好的培训计划将继续提供优秀的博士前培训， 微生物致病机理和基因组学。