Coordination Section

协调科

• 批准号: 10670771
• 负责人: Jason D. Heaney
• 金额: $ 26.45万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670771
• 关键词: Animal Model; Area; Bioinformatics; Biomedical Research; Caring; Communication; Communities; Data Reporting; Development; Diagnostic; Electronics; Ensure; Funding; Goals; Governing Board; Grant; Human; Individual; International; Lead; Leadership; Measures; Medical Genetics; Mendelian disorder; Modeling; Molecular Genetics; Monitor; Patients; Phenotype; Procedures; Production; Progress Reports; Publications; Rare Diseases; Reporting; Research; Research Personnel; Resources; Schedule; Services; Site Visit; United States National Institutes of Health; Variant; Work; experience; genetic variant; human disease; meetings; member; model organism; multidisciplinary; operation; organizational structure; outreach; personalized medicine; precision medicine; preclinical study; programs; recruit; tool; web site; working group

ABSTRACT The BCM Center for Precision Medicine Modeling will support local, national, and international programs and individual researchers in the development of precision animal models that (1) end the diagnostic odyssey of patients with undiagnosed, rare, and Mendelian diseases and (2) serve as resources for pre-clinical studies investigating personalized medicine approaches to their care. The Coordination Section led by the Center multi- PI group and overseen by the Center Steering Committee, will harmonize the workflows within and between the Center’s sections and units and enact tools and metrics to monitor Center progress and impact on biomedical research. The Coordination Section will be responsible for maintaining internal and external Center communications by scheduling meetings of section/unit working groups, all center staff, and the Center Steering Committee. These meetings will be used to review section/unit operations, track project and milestone progress, and select nominated variants for modeling. The Coordination Section will organize External Advisory Board (EAB) site visits and will be responsible for implementing corrective measures identified by the EAB. To streamline operations, the Coordination Section will work with each Section and Unit to establish Standard Operating Procedures during the first year. Finally, the Coordination section will work with the Bioinformatics and Resources and Services Sections to implement a communication and outreach strategy to recruit community- based nominations of human allele variants.

摘要 该中心的精准医学建模将支持地方，国家和国际计划， 个体研究人员在开发精确的动物模型，（1）结束诊断奥德赛 未确诊的罕见疾病和孟德尔疾病患者，（2）作为临床前研究的资源 研究个性化医疗方法来治疗他们。由中心牵头的协调科， PI小组在中心指导委员会的监督下，将协调 中心的部门和单位，并制定工具和指标，以监测中心的进展和对生物医学的影响 research.协调科将负责维护内部和外部中心 通过安排科/股工作组、中心全体工作人员和中心指导委员会的会议进行沟通 以马克思这些会议将用于审查科/股的业务，跟踪项目和里程碑的进展， 并选择用于建模的指定变量。协调科将组织外部咨询委员会 (EAB)现场访问，并负责实施EAB确定的纠正措施。到 为了精简业务，协调科将与各科和各股合作， 第一年的操作程序。最后，协调科将与生物信息学和 资源和服务科执行沟通和外联战略， 基于人类等位基因变体的提名。