Coordination Section

协调科

• 批准号: 10259805
• 负责人: Jason D. Heaney
• 金额: $ 26.45万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10259805
• 关键词: Animal Model; Area; Bioinformatics; Biomedical Research; Caring; Communication; Communities; Data Reporting; Development; Diagnostic; Ensure; Funding; Goals; Governing Board; Grant; Human; Individual; International; Lead; Leadership; Measures; Medical Genetics; Mendelian disorder; Modeling; Molecular Genetics; Monitor; Patients; Phenotype; Procedures; Production; Publications; Rare Diseases; Reporting; Research; Research Personnel; Resources; Schedule; Services; Site Visit; Supervision; United States National Institutes of Health; Variant; Work; base; bioinformatics resource; experience; genetic variant; human disease; meetings; member; multidisciplinary; operation; organizational structure; outreach; personalized medicine; precision medicine; preclinical study; programs; recruit; tool; web site; working group

ABSTRACT The BCM Center for Precision Medicine Modeling will support local, national, and international programs and individual researchers in the development of precision animal models that (1) end the diagnostic odyssey of patients with undiagnosed, rare, and Mendelian diseases and (2) serve as resources for pre-clinical studies investigating personalized medicine approaches to their care. The Coordination Section led by the Center multi- PI group and overseen by the Center Steering Committee, will harmonize the workflows within and between the Center’s sections and units and enact tools and metrics to monitor Center progress and impact on biomedical research. The Coordination Section will be responsible for maintaining internal and external Center communications by scheduling meetings of section/unit working groups, all center staff, and the Center Steering Committee. These meetings will be used to review section/unit operations, track project and milestone progress, and select nominated variants for modeling. The Coordination Section will organize External Advisory Board (EAB) site visits and will be responsible for implementing corrective measures identified by the EAB. To streamline operations, the Coordination Section will work with each Section and Unit to establish Standard Operating Procedures during the first year. Finally, the Coordination section will work with the Bioinformatics and Resources and Services Sections to implement a communication and outreach strategy to recruit community- based nominations of human allele variants.

抽象的 BCM 精准医学建模中心将支持地方、国家和国际项目以及 个体研究人员开发精密动物模型，（1）结束诊断之旅 患有未确诊、罕见和孟德尔疾病的患者，以及 (2) 作为临床前研究的资源 研究针对他们的护理的个性化医疗方法。协调科由中心多方牵头 PI 小组由中心指导委员会监督，将协调中心内部和中心之间的工作流程 中心的部门和单位，并制定工具和指标来监测中心的进展和对生物医学的影响 研究。协调科负责维护中心内部和外部 通过安排部门/单位工作组、所有中心工作人员和中心指导会议的会议进行沟通 委员会。这些会议将用于审查部门/单位的运作，跟踪项目和里程碑的进展， 并选择指定的变体进行建模。协调科将组织外部顾问委员会 (EAB) 进行现场视察，并将负责实施 EAB 确定的纠正措施。到 简化操作，协调科将与各部门和单位合作制定标准 第一年的操作程序。最后，协调部分将与生物信息学和 资源和服务部门实施沟通和外展战略以招募社区 - 基于人类等位基因变异的提名。