Ultrafine Particulate Monitor for Personal Exposure Assessment

用于个人暴露评估的超细颗粒监测仪

• 批准号: 10670861
• 负责人: David Michael Woolsey
• 金额: $ 88.34万
• 依托单位: AERODYNE MICROSYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10670861
• 关键词: Acoustics; Acute; Aerosols; Air; Air Movements; Air Pollutants; Airborne Particulate Matter; Aircraft; Area; Asthma; Automobiles; Behavior; Benchmarking; Calibration; Cardiovascular Diseases; Caring; Cessation of life; Chronic; Compensation; Data; Data Set; Deposition; Detection; Development; Devices; Diameter; Disease; Electronics; Environment; Environmental Exposure; Environmental Pollutants; Epidemiologic Monitoring; Etiology; Evaluation; Exposure to; Film; Force of Gravity; Frequencies; Generations; Government; Health; Heating; Home; Humidity; Industrial Health; Laboratories; Link; Malignant neoplasm of lung; Marketing; Measurement; Measures; Mechanics; Medical; Methods; Microfluidics; Modeling; Modification; Monitor; Myocardial Infarction; Optics; Outcome; Particulate; Particulate Matter; Performance; Persons; Pharmacologic Substance; Phase; Pollution; Powder dose form; Power Plants; Public Health; Qualifying; Research; Resolution; Respiratory Disease; Sampling; Signal Transduction; Small Business Innovation Research Grant; Stream; Structure; System; Techniques; Technology; Thinness; Time; Ultrafine; Uncertainty; United States; Validation; Weight; Work; Workplace; air sampling; cost; design; epidemiology study; exhaust; extreme temperature; fine particles; improved; instrument; meter; microsystems; miniaturize; nanoparticle; operation; particle; personal exposure monitor; power consumption; premature; prototype; real time monitoring; rechargeable battery; sensor; software development; technology platform; temporal measurement; validation studies; ventilation; wood smoke

Exposure to particulate air pollutants is associated with cardiovascular disease, asthma, lung cancer, and other illnesses. In the United States the CDC estimates that asthma costs $20 billion annually in medical care, lost workdays, and early deaths. However, due to the complexity of the environmental exposure mechanisms, there remains a degree of uncertainty concerning disease etiology. Wearable and highly-sensitive particulate sensors could help further elucidate the linkages between disease and particulate exposure. In this Small Business Innovation Research Phase 2 project Aerodyne Microsystems Inc. (AMI) will investigate the feasibility of a miniaturized, battery-powered, and inexpensive sensor for real-time monitoring of exposure to airborne particulate matter (PM) from 2.5 um to ultrafine. The system employs the thermophoretic deposition of particulates from a sample air stream onto a thin-film bulk acoustic wave resonator (FBAR), and determines the PM mass deposited by measuring the frequency shift of oscillation. Incorporation of micromachined-electromechanical-system (MEMS) technologies allows unprecedented reduction in power consumption, cost, sample flow rate, and size. The research plan is to develop and experimentally demonstrate a new method for generation of air flow in the device, demonstrate sensor operation across a wide range of harsh, real-world operating conditions, and realize a new technique for aerosol sampling and handling that improves the sensor level of detection. The successful outcome of the project would culminate in a low-cost analytical instrument that provides real-time mass concentration of particles in a compact, wearable form factor. The monitor would be suitable for quantification of personal exposure to a range of environmental pollutants such as automotive exhaust, wood smoke, and nanoparticles. Other markets for the instrument include ventilation control, industrial hygiene, power plant monitoring, pharmaceutical powder processing, monitoring in aircraft and automobiles, and consumer air quality monitoring.

暴露于颗粒空气污染物与心血管疾病，哮喘，肺癌和其他 疾病。在美国，疾病预防控制中心估计，哮喘每年在医疗服务中耗资200亿美元，损失 工作日和早期死亡。但是，由于环境暴露机制的复杂性， 关于疾病病因的不确定性仍然一定程度。可穿戴和高度敏感的颗粒物 传感器可以帮助进一步阐明疾病与颗粒物暴露之间的联系。 在这个小型企业创新研究阶段2项目Aerodyne Microsystems Inc.（AMI）将调查 微型，电池供电和廉价传感器的可行性用于实时监测暴露 从2.5 um到超级固定物质（PM）。该系统采用嗜热剂 从样品空气流中的颗粒物沉积到薄膜大块的声波谐振器（FBAR）和 通过测量振荡的频移来确定沉积的PM质量。合并 微机械电机机电系统（MEMS）技术允许降低功率 消费，成本，样本流量和大小。 研究计划是开发和实验证明一种新方法，用于生成空气流程 设备，在各种苛刻，现实世界的操作条件上演示传感器操作，并且 实现一种用于气溶胶采样和处理的新技术，以提高传感器检测水平。这 该项目的成功结果将在提供实时的低成本分析工具中达到顶峰 紧凑，可穿戴的外形质量的质量浓度。监视器适合 量化个人暴露于各种环境污染物（例如汽车排气，木材） 烟雾和纳米颗粒。该工具的其他市场包括通风控制，工业卫生， 电厂监测，药物粉末加工，飞机和汽车的监控以及 消费者空气质量监测。