Ultrafine Particulate Monitor for Personal Exposure Assessment

用于个人暴露评估的超细颗粒监测仪

• 批准号: 10852019
• 负责人: David Michael Woolsey
• 金额: $ 11.02万
• 依托单位: AERODYNE MICROSYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10852019
• 关键词: Acoustics; Aerosols; Air; Air Pollutants; Airborne Particulate Matter; Area; Asthma; Businesses; Cardiovascular Diseases; Caring; Cessation of life; Data; Deposition; Development Plans; Device or Instrument Development; Disease; Environment; Environmental Exposure; Epidemiologic Monitoring; Etiology; Exposure to; Film; Fostering; Frequencies; Growth; Health; Home; Human; Liquid substance; Malignant neoplasm of lung; Measurement; Measures; Medical; Monitor; Outcome; Particulate; Particulate Matter; Phase; Pollution; Public Health; Research; Sampling; Small Business Innovation Research Grant; Stream; System; Technology; Thinness; Time; Ultrafine; Uncertainty; United States; Work; Workplace; air sampling; career development; commercial prototype; cost; epidemiology study; experience; instrument; microsystems; miniaturize; particle; personal exposure monitor; power consumption; real time monitoring; sensor; simulation; technology platform

Exposure to particulate air pollutants is associated with cardiovascular disease, asthma, lung cancer, and other illnesses. In the United States the CDC estimates that asthma costs $20 billion annually in medical care, lost workdays, and early deaths. However, due to the complexity of the environmental exposure mechanisms, there remains a degree of uncertainty concerning disease etiology. Wearable and highly-sensitive particulate sensors could help further elucidate the linkages between disease and particulate exposure. In the Small Business Innovation Research Phase 2 project, Aerodyne Microsystems Inc. (AMI) is investigating the feasibility of a miniaturized, battery-powered, and inexpensive sensor for real-time monitoring of exposure to airborne particulate matter (PM) from 2.5 um to ultrafine. The system employs the thermophoretic deposition of particulates from a sample air stream onto a thin-film bulk acoustic wave resonator (FBAR) and determines the PM mass deposited by measuring the frequency shift of oscillation. Incorporation of micromachined-electromechanical-system (MEMS) technologies allows unprecedented reduction in power consumption, cost, sample flow rate, and size. The successful outcome of the project would culminate in a low-cost analytical instrument that provides real-time mass concentration of particles in a compact, wearable form factor. The research plan covered in this diversity supplement will guide AMI’s work towards a prototype commercial monitor capable of aerosol size fractionization. The project will further extend Mohammadreza (Reza) Khani’s, the project supplementee, experience in computational fluid dynamics (CFD) simulations geared towards device development related to human health. The career development plan described in this project will foster Reza’s growth in many areas related to becoming a leading entrepreneur in small businesses.

暴露于颗粒空气污染物与心血管疾病、哮喘、肺癌和其他疾病有关。 疾病。在美国，疾病预防控制中心估计哮喘每年花费200亿美元用于医疗保健， 工作日和早逝然而，由于环境暴露机制的复杂性， 关于疾病的病因仍存在一定程度的不确定性。可穿戴和高度敏感的颗粒 传感器可以帮助进一步阐明疾病和接触微粒之间的联系。 在小企业创新研究第二阶段项目中，Aerodyne Microsystems Inc. (AMI)正在调查 小型化、电池供电和廉价传感器用于实时监测暴露的可行性 空气中的颗粒物（PM）从2.5微米到超细。该系统采用热泳 将来自样品空气流的微粒沉积到薄膜体声波谐振器（FBAR）上，以及 通过测量振荡的频移来确定沉积的PM质量。掺入 微机械机电系统（MEMS）技术允许前所未有的功率降低 消耗、成本、样品流速和尺寸。该项目的成功结果将导致 一种低成本的分析仪器，可在紧凑、可穿戴的环境中提供颗粒的实时质量浓度， 形状因素。 本多样性补充材料中所涵盖的研究计划将指导AMI的原型商业工作 能够对气溶胶尺寸进行分级的监测器。该项目将进一步扩大Mohammadreza（Reza）Khani的， 该项目的参与者，在计算流体动力学（CFD）模拟的经验，面向 与人类健康相关的设备开发。本项目中描述的职业发展计划将促进 Reza在许多领域的成长都与成为小企业的领先企业家有关。