Elucidating perifoveal vascular development in infants

阐明婴儿中心凹周围血管发育

基本信息

  • 批准号:
    10696178
  • 负责人:
  • 金额:
    $ 39.89万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-30 至 2027-08-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY One out of every ten infants is born preterm. Preterm birth can cause retinopathy of prematurity (ROP), a leading cause of childhood blindness. Even in the absence of ROP or neurological disability, children born preterm exhibit subtle impairments in visual acuity and visual function, though the etiology of this suboptimal vision in preterm infants remains unclear. The fovea, an indentation in the central retina, is the most critical region determining visual acuity. The fovea is surrounded by anastomosis of three layers of capillaries, forming the foveal avascular zone. It is well-established that children and adults with history of prematurity have a small or absent foveal avascular zone, retained foveal inner retinal layers, and decreased photoreceptor function, and that these abnormalities are more severe in individuals with history of treated ROP. The development of human perifoveal vasculature, however, is difficult to study due to the absence of fovea in most easily accessible animal models and the rarity of human histopathological samples during late gestation. Our multidisciplinary team with complementary expertise will work together to use advanced bedside handheld optical coherence tomography (OCT) angiography imaging to fill the gap in our knowledge of perifoveal vascular development in infants. We propose to elucidate the human perifoveal vascular development through the following specific aims: 1) optimize bedside handheld infant OCT angiography to visualize perifoveal vascular development; 2) determine if perifoveal vascular development is delayed in preterm infants compared to term infants, further delayed in ROP, and associates with poor outer retinal maturation; and 3) determine the association of macular edema and decreased perifoveal deep vascular complex formation and outer retinal maturation in preterm infants. This research will expand our knowledge of human foveal development and inform the pathophysiology of diseases of macular and retinal vascular development.
项目总结

项目成果

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Xi Chen其他文献

Xi Chen的其他文献

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{{ truncateString('Xi Chen', 18)}}的其他基金

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用于活体动物多光子成像的高通量闭环直接像差传感和校正
  • 批准号:
    10572572
  • 财政年份:
    2023
  • 资助金额:
    $ 39.89万
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Crosstalk between the ER Stress Response and Mitochondrial Fatty Acid Oxidation in MYC-driven Breast Cancer
MYC 驱动的乳腺癌中 ER 应激反应与线粒体脂肪酸氧化之间的串扰
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    10581179
  • 财政年份:
    2023
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    2022
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    $ 39.89万
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A Life Course Approach to Understanding Racial and Ethnic Disparities in Alzheimer's Disease and Related Dementias and Health Care
了解阿尔茨海默病及相关痴呆症和医疗保健中种族和民族差异的生命全程方法
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    10650381
  • 财政年份:
    2022
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    $ 39.89万
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A Life Course Approach to Understanding Racial and Ethnic Disparities in Alzheimer's Disease and Related Dementias and Health Care
了解阿尔茨海默病及相关痴呆症和医疗保健中的种族和民族差异的生命全程方法
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  • 财政年份:
    2022
  • 资助金额:
    $ 39.89万
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Chemoenzymatic construction of synthetic human milk oligosaccharide (HMO) glycome
合成人乳低聚糖 (HMO) 糖组的化学酶法构建
  • 批准号:
    10567752
  • 财政年份:
    2022
  • 资助金额:
    $ 39.89万
  • 项目类别:
Chemoenzymatic construction of synthetic human milk oligosaccharide (HMO) glycome
合成人乳低聚糖 (HMO) 糖组的化学酶法构建
  • 批准号:
    10710393
  • 财政年份:
    2022
  • 资助金额:
    $ 39.89万
  • 项目类别:
Improving oral health awareness and dental referrals for adult patients receiving palliative care
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  • 财政年份:
    2021
  • 资助金额:
    $ 39.89万
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Chemoenzymatic synthesis of bacterial nonulosonic acids and glycans
细菌非酮糖酸和聚糖的化学酶法合成
  • 批准号:
    10364735
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    2021
  • 资助金额:
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  • 项目类别:
Chemoenzymatic synthesis of bacterial nonulosonic acids and glycans
细菌非酮糖酸和聚糖的化学酶法合成
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    10553186
  • 财政年份:
    2021
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    $ 39.89万
  • 项目类别:

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