Adult Changes in Thought (ACT) Research Program Core E: Neuroimaging Core

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CORE E: ACT NEUROIMAGING CORE Summary/Abstract The Neuroimaging Core provides the technical and analytic expertise to elucidate interactions between the complex neurobiological aging processes studied across all U19 Projects and Cores. The Aims of the core include collection and analysis of new MRI scans, collection and analysis of post-mortem high resolution ex vivo brain MRI scans for alignment with the excised brain tissue, examination of image-guided tissue sampling to supplement neuropathological analysis, and the application of machine learning and artificial intelligence (AI) techniques to enhance imaging data collected in ACT participants that will support the Projects and other cores in the ACT U19 Program. The Neuroimaging Core will leverage data science techniques and apply rigorous methods to analyze how longitudinal imaging data collected from ACT participants interact with related clinical, genetic, neuropathological, laboratory, and pharmacy information. The Neuroimaging Core will create synergy within the Program by contributing data and providing imaging analyses to the Projects, helping to integrate the Program through close collaboration with the other Cores especially the Neuropathology and Data and Analysis Cores, and will work as a conduit for sharing knowledge and ideas as they arise in the Program, all of which helps the ACT U19 Program accomplish more than the individual Projects could achieve alone.