Circulating lipid and miRNA markers for early detection of breast cancer among women with abnormal mammograms

循环脂质和 miRNA 标记物用于乳房 X 光检查异常女性乳腺癌的早期检测

基本信息

  • 批准号:
    10673061
  • 负责人:
  • 金额:
    $ 53.04万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-08-01 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Breast cancer is the most common cancer among women in the world. When breast cancer is found in early stages, it can be effectively treated or even cured, but treating a patient in later stages is very difficult. Thus, early detection of breast cancer is critical. Mammography is the current gold standard for breast cancer screening; however, most women with abnormal mammograms are eventually found not to have breast cancer. Fewer than 5 per 1,000 women actually have the disease when they are screened. Therefore, most abnormal mammograms are false positives that require further investigations including expensive breast imaging and biopsies, which can cause psychological distress. According to the American Cancer Society (ACS), about 10% of women who have a mammogram will be called back for more tests, but only 8% to 10% of those women will need a biopsy and 80% of those biopsies turn out to be benign. Therefore, the vast majority of the women would have undergone unnecessary investigations. Our aim is to identify circulating lipid and miRNA signatures that can be used reliably as a companion diagnostic tool together with screening mammography to reduce the number of unnecessary follow-up investigations, especially invasive biopsy. In our preliminary studies, we have identified a panel of 15 plasma lipid species that were able to distinguish early stage of cancer from benign lesions with over 90% accuracy. Using a ratio based normalization method, we have also found 5 paired plasma miRNA ratios that differentiate breast cancer from benign samples with over 90% accuracy. In order to validate our existing markers and identify potential novel markers, as well as integrate lipid and miRNA markers to increase the accuracy for early detection of breast cancer, we propose the following aims: 1. Validate and test the predictive value of circulating lipid markers for early detection of breast cancer. 2. Establish circulating miRNA markers for early detection of breast cancer. 3. Integrate circulating lipid and miRNA markers for early detection of breast cancer.
项目总结

项目成果

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专利数量(0)

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Youping Deng其他文献

Youping Deng的其他文献

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{{ truncateString('Youping Deng', 18)}}的其他基金

The Hawaii Advanced Training in Artificial Intelligence for Precision Nutrition Science Research (AIPrN)
夏威夷精准营养科学研究人工智能高级培训 (AIPRN)
  • 批准号:
    10752542
  • 财政年份:
    2023
  • 资助金额:
    $ 53.04万
  • 项目类别:
Pacific Center for Genome Research
太平洋基因组研究中心
  • 批准号:
    10749842
  • 财政年份:
    2023
  • 资助金额:
    $ 53.04万
  • 项目类别:
Characterizing genomic risk factors of lung cancers in Native Hawaiians
夏威夷原住民肺癌基因组风险因素的特征
  • 批准号:
    10749847
  • 财政年份:
    2023
  • 资助金额:
    $ 53.04万
  • 项目类别:
Bioinformatics Core
生物信息学核心
  • 批准号:
    10576204
  • 财政年份:
    2022
  • 资助金额:
    $ 53.04万
  • 项目类别:
Circulating lipid and miRNA markers for early detection of breast cancer among women with abnormal mammograms
循环脂质和 miRNA 标记物用于乳房 X 光检查异常女性乳腺癌的早期检测
  • 批准号:
    10459379
  • 财政年份:
    2019
  • 资助金额:
    $ 53.04万
  • 项目类别:
Circulating lipid and miRNA markers for early detection of breast cancer among women with abnormal mammograms
循环脂质和 miRNA 标记物用于乳房 X 光检查异常女性乳腺癌的早期检测
  • 批准号:
    9982252
  • 财政年份:
    2019
  • 资助金额:
    $ 53.04万
  • 项目类别:
Circulating lipid and miRNA markers for early detection of breast cancer among women with abnormal mammograms
循环脂质和 miRNA 标记物用于乳房 X 光检查异常女性乳腺癌的早期检测
  • 批准号:
    10218097
  • 财政年份:
    2019
  • 资助金额:
    $ 53.04万
  • 项目类别:
Profiling genome-wide circulating ncRNAs for the early detection of lung cancer
分析全基因组循环 ncRNA 以早期检测肺癌
  • 批准号:
    10477044
  • 财政年份:
    2018
  • 资助金额:
    $ 53.04万
  • 项目类别:
Profiling genome-wide circulating ncRNAs for the early detection of lung cancer
分析全基因组循环 ncRNA 以早期检测肺癌
  • 批准号:
    10242187
  • 财政年份:
    2018
  • 资助金额:
    $ 53.04万
  • 项目类别:
Profiling genome-wide circulating ncRNAs for the early detection of lung cancer
分析全基因组循环 ncRNA 以早期检测肺癌
  • 批准号:
    10000889
  • 财政年份:
    2018
  • 资助金额:
    $ 53.04万
  • 项目类别:

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