Data Science Core for Biomedical Research

生物医学研究的数据科学核心：综述 数据科学(DS)核心是提供专业和及时的生物信息学的集中资源 以及其他与DS相关的咨询、分析、协作研究、管理和培训解决方案 广泛的高通量生物医学数据。DS核心将通过以下方式支持HI-INBRE V的具体目标 在研究、教育、调查和创新创造方面提供强大的综合DS服务 方法论。 在第四届INBRE期间，生物信息学核心取得了实质性进展，为 过渡到DS核心。我们使用DS Core的研究人员数量每年都在增加 几乎所有HI-INBRE机构的服务。DS Core已成功提供 为HI-INBRE社区提供生物信息学/生物统计学和其他DS培训和教育机会。 在INBRE IV期间，核心基础设施也得到了显著增强，几位博士级别的数据科学家 都被录用了。核心成功地促进了同行评议的出版物、赠款申请和帮助 调查人员获得了各种研究奖项。 在INBRE V中，DS核心将继续作为网络的重要组成部分发挥作用。具体来说， DS Core将在三个关键方面为INBRE V的目标做出贡献：(I)定制服务：DS Core将 促进HI-INBRE为赠款申请和后续研究获得初步数据 研究人员通过咨询实验设计和数据管理，并提供数据方面的专业知识 分析和解释；(2)教育和培训：DS核心将提供DS方面的教育以及 支持学生和新教师研究人员的职业发展，并特别关注 向本科生培训DS技能；(Iii)核心开发：DS核心将创建工具和方法 或者重新调整现有工具和战略的用途，以加快科学进步。在所有这些活动中， DS Core将与其他地方和国家生物信息学和DS Core合作。要达到这些目标 在目标方面，我们提出了三个具体目标： (1)提供DS核心服务，支持HI-INBRE研究人员的生物医学研究需求。 (2)满足生物医学教师的高技能需求，他们的研究正在变得越来越计算机化 密集的。 (3)加强夏威夷的生物医学DS管道。 1

DATA SCIENCE CORE FOR BIOMEDICAL RESEARCH: SUMMARY The Data Science (DS) Core serves as a centralized resource for providing expert and timely bioinformatics and other DS-related consulting, analysis, collaborative research, management, and training solutions for a broad range of high-throughput biomedical data. The DS Core will support the specific aims of HI-INBRE V by providing a strong and integrated DS service in research, education, investigation, and creation of innovative methodologies. During INBRE IV, the Bioinformatics Core made substantial progress to serve as a solid foundation for transition to the DS Core. We experienced an annual increase in the number of researchers utilizing the DS Core services from almost all the HI-INBRE institutions. The DS Core has successfully provided bioinformatics/biostatistics and other DS training and education opportunities to the HI-INBRE community. During INBRE IV, the core infrastructure was also significantly enhanced and several Ph.D. level data scientists were hired. The core has successfully contributed to peer-reviewed publications, grant applications and helped investigators to obtain a variety of research awards. In INBRE V, the DS Core will continue to function as an important component of the network. Specifically, the DS Core will contribute to INBRE V objectives in three key ways: (i) Customized Services: the DS Core will facilitate the acquisition of preliminary data for grant applications and subsequent research by HI-INBRE investigators via consultation on experimental design and data management as well as offer expertise in data analysis and interpretation; (ii) Education and Training: the DS Core will provide education in DS, as well as support career development for student and emerging faculty researchers, with special attention given for training DS skills to undergraduate students; (iii) Core Development: the DS Core will create tools and methods or repurpose existing tools and strategies to accelerate advances in the sciences. In all of these activities, the DS Core will work collaboratively with other local and national bioinformatics and DS cores. To reach these goals, we propose three Specific Aims: (1) Provide DS core services to support biomedical research needs of HI-INBRE investigators. (2) Meet the upskilling needs of biomedical faculty whose research is becoming increasing computationally intensive. (3) Enhance the biomedical DS pipeline in Hawaii. 1