Bioinformatics Core

生物信息学核心项目摘要 强大的生物信息学工具的爆炸式增长和注释良好的数据库的不断完善， 加速了对无数遗传和表观遗传决定因素的新知识的获得， 传染病和其他疾病给人类造成了难以形容的痛苦。在这方面，大数据科学 为改善人类健康提供个性化、预测性、预防性和参与性医学的希望 预防疾病。因此，维持生物信息学核心的重要性不能被夸大。期间 COBRE第二阶段，生物信息学核心主要强调提供定制的支持， 合作服务，开发新的和改进的生物信息学工具， 教育课程和实践培训讲习班。 COBRE第三阶段的目标是促进生物信息学核心向可持续状态的过渡， 最先进的核心设施，能够支持新的，新兴的和重新崛起的高素质研究 传染病，以及其他领域的科学调查，将实现（1）加强和 精简核心业务;（2）扩大用户基础、能力、容量和覆盖范围并使之多样化; (3)加强核心基础设施建设。就目标1而言，需要评估和用户满意度调查将 确保核心业务在核心/用户界面和用户界面的效率和效力 服务就目标2而言，外联和营销活动将扩大到其他本地学术机构， UH系统以外的生物技术公司和医院，并将与类似的 位于其他COBRE、INBRE和IDEA-CTR计划中的核心，以进一步发展核心用户并使其多样化 并获得新的工具和技术。至于目标3，制度化和分阶段实施的业务计划 将在COBRE第三阶段期间开发，以利用内部和外部资源实现可持续性。 据设想，生物信息学核心将实现上述每一个具体目标。一个强大 UH系统总裁承诺全力支持生物信息学核心基础设施， 在未来五年内增加专业职位和支助人员是一个更大的战略计划的一部分， 将生物信息学制度化，成为网络基础设施司的四大支柱之一。因此，在本发明中， 我们有充分的理由乐观地认为，生物信息学核心将转变为一个全系统的 生物信息学资源，以应对大数据科学的挑战。

Project Summary for the Bioinformatics Core Explosive growth in powerful bioinformatics tools and continued refinements in well-annotated databases have accelerated the acquisition of new knowledge about the myriad genetic and epigenetic determinants of infectious diseases and other diseases that cause untold human suffering. In this regard, big-data science holds the promise for personalized, predictive, preventive and participatory medicine to improve human health and prevent disease. Thus, the importance of sustaining the Bioinformatics Core cannot be overstated. During COBRE Phase II, the Bioinformatics Core placed a major emphasis on providing customized support and collaborative services, on developing new and improved bioinformatics tools, and on conducting intensive educational courses and hands-on training workshops. The Phase III COBRE objective of facilitating the transition of the Bioinformatics Core into a sustainable state- of-the-art core facility capable of supporting high-caliber research on new, emerging and re-emerging infectious diseases, as well as other fields of scientific inquiry, will be achieved by (1) enhancing and streamlining core operations; (2) growing and diversifying the user base, capability, capacity and reach; and (3) strengthening the core infrastructure. For Aim 1, needs assessments and user satisfaction surveys will be conducted to ensure efficiency and effectiveness of core operations at the core/user interface and user services. For Aim 2, outreach and marketing activities will be expanded to other local academic institutions, biotech companies and hospitals beyond the UH System, and strong partnerships will be formed with similar cores located in other COBRE, INBRE and IDeA-CTR programs to further grow and diversify the core user base and to acquire new tools and techniques. And for Aim 3, institutionalization and phased-in business plans will be developed during the Phase III COBRE to draw on intramural and extramural sources for sustainability. It is envisioned that the Bioinformatics Core will achieve each of the above-stated specific aims. A strong commitment by the President of the UH System to fully support the Bioinformatics Core infrastructure, with professional positions and support staff, within the next five years is part of a larger strategic plan to institutionalize bioinformatics as one of the four principal pillars in the Division of Cyberinfrastructure. Thus, there is every reason to be optimistic that the Bioinformatics Core will be transformed into a system-wide bioinformatics resource to confront the challenges of big-data science.