Bioinformatics Core

生物信息学核心

• 批准号: 10576204
• 负责人: Youping Deng
• 金额: $ 19.35万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-14 至 2023-07-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10576204
• 关键词: Adopted; Adoption; Award; Basic Science; Bioinformatics; Biological Sciences; Biology; Biomedical Research; Biotechnology; Businesses; Caliber; Centers of Research Excellence; Clinical Sciences; Collaborations; Communicable Diseases; Communities; Community of Practice; Core Facility; Custom; Data; Data Analyses; Databases; Development; Discipline; Disease; Educational workshop; Effectiveness; Emerging Communicable Diseases; Ensure; Epigenetic Process; Equilibrium; Extramural Activities; Faculty; Fostering; Funding; Funding Agency; Generations; Genetic; Genomics; Growth; Hawaii; Health; Hospitals; Human; Infectious Diseases Research; Information Technology; Infrastructure; Institution; Institutionalization; Knowledge; Letters; Marketing; Medicine; Methods; Mission; Needs Assessment; Occupations; Performance; Phase; Play; Positioning Attribute; Preventive; Privatization; Procedures; Process; Rapid diagnostics; Research; Research Personnel; Resources; Risk; Role; Science; Scientific Inquiry; Services; Source; Strategic Planning; Stream; Surveys; System; Techniques; Technology; Time; Training; Training and Education; Translational Research; Universities; Vaccines; Work; base; big-data science; bioinformatics infrastructure; bioinformatics resource; bioinformatics tool; biological research; cohesion; complex biological systems; computing resources; cyber infrastructure; design; empowered; improved; next generation sequencing; operation; outreach; personalized predictions; prevent; programs; satisfaction; success; therapeutically effective; tool; user-friendly; web portal

Project Summary for the Bioinformatics Core Explosive growth in powerful bioinformatics tools and continued refinements in well-annotated databases have accelerated the acquisition of new knowledge about the myriad genetic and epigenetic determinants of infectious diseases and other diseases that cause untold human suffering. In this regard, big-data science holds the promise for personalized, predictive, preventive and participatory medicine to improve human health and prevent disease. Thus, the importance of sustaining the Bioinformatics Core cannot be overstated. During COBRE Phase II, the Bioinformatics Core placed a major emphasis on providing customized support and collaborative services, on developing new and improved bioinformatics tools, and on conducting intensive educational courses and hands-on training workshops. The Phase III COBRE objective of facilitating the transition of the Bioinformatics Core into a sustainable state- of-the-art core facility capable of supporting high-caliber research on new, emerging and re-emerging infectious diseases, as well as other fields of scientific inquiry, will be achieved by (1) enhancing and streamlining core operations; (2) growing and diversifying the user base, capability, capacity and reach; and (3) strengthening the core infrastructure. For Aim 1, needs assessments and user satisfaction surveys will be conducted to ensure efficiency and effectiveness of core operations at the core/user interface and user services. For Aim 2, outreach and marketing activities will be expanded to other local academic institutions, biotech companies and hospitals beyond the UH System, and strong partnerships will be formed with similar cores located in other COBRE, INBRE and IDeA-CTR programs to further grow and diversify the core user base and to acquire new tools and techniques. And for Aim 3, institutionalization and phased-in business plans will be developed during the Phase III COBRE to draw on intramural and extramural sources for sustainability. It is envisioned that the Bioinformatics Core will achieve each of the above-stated specific aims. A strong commitment by the President of the UH System to fully support the Bioinformatics Core infrastructure, with professional positions and support staff, within the next five years is part of a larger strategic plan to institutionalize bioinformatics as one of the four principal pillars in the Division of Cyberinfrastructure. Thus, there is every reason to be optimistic that the Bioinformatics Core will be transformed into a system-wide bioinformatics resource to confront the challenges of big-data science.

生物信息学核心的项目总结 强大的生物信息学工具的爆炸性增长和注释良好的数据库的持续完善 加速获得关于多种遗传和表观遗传决定因素的新知识 传染病和其他给人类带来难以形容的痛苦的疾病。在这方面，大数据科学 拥有改善人类健康的个性化、预测性、预防性和参与性医学的前景 并预防疾病。因此，维持生物信息学核心的重要性怎么强调都不为过。在.期间 在Cobre第二阶段，生物信息学核心主要强调提供定制的支持和 协作服务，开发新的和改进的生物信息学工具，并进行密集 教育课程和实践培训讲习班。 Cobre第三阶段的目标是促进生物信息学核心向可持续状态的转变- 最先进的核心设施，能够支持对新的、新兴的和重新出现的高水平研究 传染病以及其他科学研究领域将通过以下方式实现：(1)加强和 精简核心业务；(2)扩大和多样化用户基础、能力、能力和覆盖范围；以及 (三)强化核心基础设施。对于目标1，将进行需求评估和用户满意度调查 为确保核心/用户界面和用户的核心操作的效率和效力而进行 服务。对于目标2，外联和营销活动将扩大到其他地方学术机构， UH系统之外的生物技术公司和医院，并将与类似的 位于其他Cobre、INBRE和IDEA-CTR计划中的核心，以进一步增长核心用户并使其多样化 建立基础，并获得新的工具和技术。对于目标3，制度化和分阶段实施业务计划 将在第三阶段眼镜蛇期间开发，以利用可持续发展的墙内和墙外来源。 预计生物信息学核心将实现上述每一个具体目标。一个坚强的人 UH系统总裁承诺全力支持生物信息学核心基础设施， 专业职位和支助人员，是未来五年更大战略计划的一部分 使生物信息学制度化，将其作为数字基础设施司的四大支柱之一。因此， 我们完全有理由乐观地认为，生物信息学核心将转变为全系统的 生物信息学资源以应对大数据科学的挑战。