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Personalized Cystic Fibrosis Therapy and Research Center

个性化囊性纤维化治疗和研究中心

基本信息

批准号：
10672705
负责人：
John Joseph Brewington
金额：
$ 23.36万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10672705
关键词：
Address Age Aging Basic Science Biological Markers Biological Models Biology Biometry Bronchoalveolar Lavage Fluid Bronchoscopy Caring Caucasians Cells Childhood Clinic Clinical Clinical Research Clinical Trials Collaborations Colorectal Surgery Communities Consultations Coupled Cystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Data Data Analyses Disadvantaged Disease Disease Marker Emerging Technologies Enrollment Gastroenterology Goals Hispanic Hispanic Populations Human Image Individual Infant Infrastructure Institution International Intestinal Cancer Intestinal Obstruction Investigator-Initiated Research Laboratories Laboratory Finding Link Liquid substance Liver diseases Lung Magnetic Resonance Imaging Malnutrition Measurement Measures Medical center Monitor Mutation Operative Surgical Procedures Pathology Patient Care Patients Pediatric Hospitals Persons Physiological Population Population Heterogeneity Process Pulmonology Quality of life Regulator Genes Research Research Personnel Research Project Grants Research Support Resolution Resources Sampling Serum Source Spirometry Sputum Standardization Structure Time Tissues Translational Research Underserved Population United States Vision chronic care model clinical efficacy clinical investigation cohort cystic fibrosis patients cystic fibrosis related diabetes design empowerment gastrointestinal improved indexing lung imaging novel organ on a chip peer personalized care programs rare variant respiratory response tool translational scientist translational study ventilation

项目摘要

PROJECT SUMMARY: A foundational component of this P30 application is the Personalized Clinical Core, which will be the primary source of human cells, tissues, biofluids [e.g.: sweat, serum, sputum, bronchoalveolar lavage fluid (BALF),] and translational research expertise. The Personalized Clinical Core builds directly on current clinical research strengths and infrastructure at CCHMC, CSMC and UCCOM including the CFF-TDN program, the CF-RDP program, investigator-initiated research, and institutional commitments to CF translational research. The Personalized Clinical Core will expand these capabilities in critical ways, operationalizing novel translational research projects and providing direct patient relevance to cutting-edge basic science. The long- term goal of this core is to support basic science CF research with patient-derived samples from the clinic into the laboratory, and high-quality translational research moving laboratory findings into the clinic. This will be achieved through three specific aims. Specific Aims 1 and 2 will capitalize on existing partnerships and infrastructure to obtain, bank, and distribute high-quality gastrointestinal and respiratory samples, respectively, from CF and non-CF controls, paired with relevant patient data. Specific Aim 3 will provide the tools necessary to execute cutting-edge translational studies in CF, including expertise and support in novel disease markers and endpoints. Centralizing these capabilities through the Personalized Clinical Core structure will help to drive research efficiencies and standardization. In addition, the samples obtained and processed through the Personalized Clinical Core will be available for direct use by CF researchers, and for projects utilizing the Personalized Model System Core and the CF-Organ-On-a-Chip Core.

项目概要：该P30应用程序的一个基本组件是个性化临床核心，它将是人类细胞、组织、生物流体的主要来源[例如：汗液、血清、痰液、支气管肺泡灌洗液（BALF），]和翻译研究的专业知识。个性化临床核心直接建立在当前临床 CCHMC，CSMC和UCCOM的研究优势和基础设施，包括CFF-TDN计划， CF-RDP计划，赞助商发起的研究，和机构承诺CF转化研究。个性化临床核心将以关键方式扩展这些功能，转化研究项目，并提供与尖端基础科学直接相关的患者。很长的- 这一核心的长期目标是支持基础科学CF研究与患者来源的样本从临床到实验室和高质量的转化研究将实验室发现转移到临床。这将是通过三个具体目标实现。具体目标1和2将利用现有的伙伴关系，分别获取、储存和分发高质量胃肠道和呼吸道样本的基础设施，来自CF和非CF对照，与相关患者数据配对。具体目标3将提供工具在CF中执行尖端转化研究所必需的，包括新型疾病的专业知识和支持标记和终点。通过个性化临床核心结构集中这些功能将有助于推动研究效率和标准化。此外，通过个性化的临床核心将可供CF研究人员直接使用，并用于利用个性化模型系统核心和CF-器官芯片核心。